Evidence map›Paper›PMID 32276991›Full record

ArticleMolecular cancer research : MCR2020

Iron Regulatory Protein 2 Exerts its Oncogenic Activities by Suppressing TAp63 Expression.

Yanhong Zhang, Xiuli Feng, Jin Zhang, Xinbin Chen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular cancer research : MCR, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. The Role of Iron in Cancer Progression.Frontiers in oncology · 2021
    Review
  5. The p53 Family: A Role in Lipid and Iron Metabolism.Frontiers in cell and developmental biology · 2021
    Review
  6. Iron and Cancer: 2020 Vision.Cancer research · 2020
    Review
  7. Iron Therapeutics in Women's Health: Past, Present, and Future.Pharmaceuticals (Basel, Switzerland) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Yanhong ZhangComparative Oncology Laboratory, Schools of Veterinary Medicine and Medicine, University of California at Davis, Davis, California.ORCID 0000-0003-4412-5641
Xiuli FengComparative Oncology Laboratory, Schools of Veterinary Medicine and Medicine, University of California at Davis, Davis, California.ORCID 0000-0001-9824-8386
Jin ZhangComparative Oncology Laboratory, Schools of Veterinary Medicine and Medicine, University of California at Davis, Davis, California.ORCID 0000-0002-6835-920X
Xinbin ChenComparative Oncology Laboratory, Schools of Veterinary Medicine and Medicine, University of California at Davis, Davis, California. xbchen@ucdavis.edu.ORCID 0000-0002-4582-6506
University of California, Davis · USNanjing Agricultural University · CN

Funding

Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI Laura Marcu · 2002 to 2026
$84.9M
The feedback loop between ferredoxin reductase and the p53 family in tumor suppressionR01CA224433 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN, XINBIN · 2018 to 2022
$2.0M
The role of the p63-RBM38 loop in tumor suppressionR01CA195828 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN, XINBIN · 2016 to 2020
$1.8M
NCI NIH HHS P30 CA093373NCI NIH HHS R01 CA195828NCI NIH HHS R01 CA224433
6 · The paper itself

Abstract

Iron regulatory protein 2 (IRP2) is a key regulator of iron homeostasis and is found to be altered in several types of human cancer. However, how IRP2 contributes to tumorigenesis remains to be elucidated. In this study, we sought to investigate the role of IRP2 in tumorigenesis and found that IRP2 promotes cell growth by repressing TAp63, a member of p53 tumor suppressor family. Specifically, we found that IRP2 overexpression decreased, whereas

Indexed as

Up-Regulation3' Untranslated RegionsAnimalsCell Line, TumorCell ProliferationCells, CulturedGene Expression Regulation, NeoplasticHep G2 CellsHumansIron Regulatory Protein 2MiceNeoplasmsNeoplasm TransplantationRNA, MessengerRNA StabilityTranscription Factors3' Untranslated RegionsIREB2 protein, humanIron Regulatory Protein 2RNA, MessengerTP63 protein, humanTranscription FactorsTumor Suppressor Proteins

Identifiers

PMID32276991
PMCPMC7749625
OpenAlexW3015946454

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.