ArticleScience immunology2020
Gut-resident CX3CR1
Abstract read
In one paragraph
Article in Science immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
78 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Multi-omic network analysis identified betacellulin as a novel target of omega-3 fatty acid attenuation of western diet-induced nonalcoholic steatohepatitis.EMBO molecular medicine · 2023Pooled it
- Review
- Review
- Interleukin-4-producing type 2 innate lymphoid cells in the lymph node promote proallergic Tfh13 cell differentiation.Immunity · 2026Article
- Tissue-Resident Macrophage PIEZO1 Transduces Mechanical Stress into Inflammatory Pain in Acute Gout.Neuroscience bulletin · 2026Article
- Tertiary Lymphoid Structure: A Potential Therapeutic Target Affecting Immune Response in Autoimmune Diseases.Clinical reviews in allergy & immunology · 2026Review
- The formation and function of tertiary lymphoid structures.Biomarker research · 2026Review
- B cell-driven immune remodeling in inflammatory bowel disease: links to pathogenesis and therapeutic failure.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Review
- Inflammation rewires the enteric nervous system through neurogenic monocyte recruitment.The Journal of experimental medicine · 2026Article
- The CXCL13 hub in obesity-related metabolic inflammation: regulation of spatiotemporal heterogeneity and targeted strategies.The Journal of endocrinology · 2026Review
- Inflammatory bowel diseases: pathological mechanisms and therapeutic perspectives.Molecular biomedicine · 2026Review
- CX3CR1 and CCR2: dynamic myeloid cell states across inflammatory diseases with implications for oral health and disease.Frontiers in immunology · 2026Review
- Article
- Spatially resolved single-cell transcriptome analysis of murineGut microbes · 2025Article
- Single-cell mapping reveals age-related alterations in periosteal progenitor cells and immune microenvironment.Cell regeneration (London, England) · 2025Article
- AMSC-EVs attenuate acute kidney injury through TXNIP-IKKα/NFκB signaling-mediated renal CX3CR1Stem cell research & therapy · 2025Article
- Lifespan-Regulated CAR-Macrophages from Myeloid Progenitors for Enhanced Colorectal Cancer Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Tertiary Lymphoid Structures Across Organs: Context, Composition, and Clinical Levers.Immunological reviews · 2025Review
- S1PR1 regulates lymphatic valve development and tertiary lymphoid organ formation in the ileum.The Journal of experimental medicine · 2025Article
- The Sunrise of Tertiary Lymphoid Structures in Cancer.Immunological reviews · 2025Review
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors.
Balázs KoscsóDepartment of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.ORCID 0000-0001-9676-2066
Sravya KurapatiDepartment of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.
Richard R RodriguesCollege of Pharmacy, Oregon State University, Corvallis, OR, USA.
Jelena NedjicDepartment of Pathology and Laura and Isaac Perlmutter Cancer Center, NYU School of Medicine, New York, NY, USA.ORCID 0000-0001-6573-4054
Kavitha GowdaDepartment of Microbiology and Immunology, Penn State University College of Medicine, Hershey, PA, USA.
Changsik ShinDepartment of Microbiology and Immunology, Penn State University College of Medicine, Hershey, PA, USA.
Chetna SoniDepartment of Microbiology and Immunology, Penn State University College of Medicine, Hershey, PA, USA.ORCID 0000-0001-7800-2338
Azree Zaffran AshrafDepartment of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.
Indira PurushothamanPhD Program in Anatomy at Penn State College of Medicine, Penn State University College of Medicine, Hershey, PA, USA.ORCID 0000-0002-4334-4546
Maryknoll PalisocMD/PhD Medical Scientist Training Program, Penn State University College of Medicine, Hershey, PA, USA.ORCID 0000-0002-5178-1279
Sulei XuDepartment of Cellular and Molecular Physiology, Penn State University College of Medicine, Hershey, PA, USA.
Haoyu SunDepartment of Cellular and Molecular Physiology, Penn State University College of Medicine, Hershey, PA, USA.ORCID 0000-0002-4741-998X
Sathi Babu ChodisettiDepartment of Microbiology and Immunology, Penn State University College of Medicine, Hershey, PA, USA.ORCID 0000-0001-7473-9420
Eugene LinDepartment of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.ORCID 0000-0001-7939-9170
Matthias MackDepartment of Internal Medicine/Nephrology, University Hospital Regensburg, Regensburg, Germany.
Yuka Imamura KawasawaDepartment of Pharmacology and Biochemistry and Molecular Biology, Institute of Personalized Medicine, Penn State University College of Medicine, Hershey, PA, USA.ORCID 0000-0002-8638-6738
Pingnian HeDepartment of Cellular and Molecular Physiology, Penn State University College of Medicine, Hershey, PA, USA.ORCID 0000-0001-7346-7419
Ziaur S M RahmanDepartment of Microbiology and Immunology, Penn State University College of Medicine, Hershey, PA, USA.
Iannis AifantisDepartment of Pathology and Laura and Isaac Perlmutter Cancer Center, NYU School of Medicine, New York, NY, USA.ORCID 0000-0001-6857-1035
Natalia ShulzhenkoCollege of Veterinary Medicine, Oregon State University, Corvallis, OR, USA.
Andrey MorgunCollege of Pharmacy, Oregon State University, Corvallis, OR, USA.ORCID 0000-0002-8924-6108
Milena BogunovicDepartment of Pathology, University of Massachusetts Medical School, Worcester, MA, USA. milena.bogunovic@umassmed.edu.ORCID 0000-0002-0247-626X
Funding
Penn State Clinical and Translational Science InstituteUL1TR002014 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KRASCHNEWSKI, JENNIFER L. · 2016 to 2025
$33.7MRole of TET2 mutations in malignant transformation and acute myeloid leukemiaR01CA173636 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI AIFANTIS, IANNIS, LEVINE, ROSS L · 2013 to 2022
$6.3MMucosal Macrophages and Tertiary Lymphoid Structures in IBDR01DK107603 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BOGUNOVIC, MILENA · 2016 to 2025
$4.0MNRSA Training CoreTL1TR002016 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI THOMAS, GAIL D. · 2016 to 2025
$3.4MRed blood cell released ATP in disturbed blood flow-initiated site specific vascular inflammation and atherosclerosisR01HL144620 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HE, PINGNIAN · 2019 to 2022
$3.1MMapping cancer micro-environments for acute leukemiaR01CA202025 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI AIFANTIS, IANNIS, SCHWAB, SUSAN RUTH · 2016 to 2020
$2.3MPost-translational control of cancer cell stress response and metastasisR01CA202027 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI AIFANTIS, IANNIS, HERNANDO, EVA · 2016 to 2020
$2.3MNitric oxide and microvessel permeability in vivoR01HL130363 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HE, PINGNIAN · 2017 to 2020
$1.9MIntegration of Enteric Immune and Nervous Systems in the Mucosal Recall Immune ResponseR21AI126351 · NIAID · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI BOGUNOVIC, MILENA · 2016 to 2017
$408kNCATS NIH HHS TL1 TR002016NCATS NIH HHS UL1 TR002014NCI NIH HHS R01 CA173636NCI NIH HHS R01 CA202025NCI NIH HHS R01 CA202027NHLBI NIH HHS R01 HL130363NHLBI NIH HHS R01 HL144620NIAID NIH HHS R21 AI126351NIDDK NIH HHS R01 DK107603
Abstract
Intestinal mononuclear phagocytes (MPs) are composed of heterogeneous dendritic cell (DC) and macrophage subsets necessary for the initiation of immune response and control of inflammation. Although MPs in the normal intestine have been extensively studied, the heterogeneity and function of inflammatory MPs remain poorly defined. We performed phenotypical, transcriptional, and functional analyses of inflammatory MPs in infectious
Indexed as
AnimalsCX3C Chemokine Receptor 1FemaleGastrointestinal MicrobiomeImmunoglobulin AInflammationIntestinal MucosaMacrophagesMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicSalmonella entericaStreptomycinTertiary Lymphoid StructuresCX3C Chemokine Receptor 1Cx3cr1 protein, mouseImmunoglobulin AStreptomycin
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.