ArticleCancer research2020
A Genome-Wide Association Study Identifies Two Novel Susceptible Regions for Squamous Cell Carcinoma of the Head and Neck.
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Article in Cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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37citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 8% of its field
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- A genome-wide association study of buccal mucosa cancer in India and multi-ancestry meta-analysis discovers risk loci and gene-environment interactions.EBioMedicine · 2025Pooled it
- Genetic susceptibility, risk prediction, and druggable targets for oropharyngeal cancer: a UK Biobank study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Associations of combined lifestyle and genetic risk with incident head and neck cancer: a prospective study in the UK Biobank.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Accelerated Biological Aging Increases the Risk of Head and Neck Cancer: Insights From Genetic Instruments of Epigenetic Clocks.Molecular carcinogenesis · 2026Article
- The CCHCR1-UBAP2L Interaction Promotes UBAP2L Release from P-Bodies for Stress Granule Assembly.International journal of molecular sciences · 2026Article
- Comprehensive analysis of the deleterious nonsynonymous, non-coding SNPs and cancer variants of human aldo-keto reductase type 1 (AKR1C1) protein and their probable association with disease risk and progression: a computational study.Biochemistry and biophysics reports · 2026Article
- Divergent immuno-landscapes: comparing the tumor microenvironment of Indian and Western HNSCC patients.Frontiers in cell and developmental biology · 2026Review
- Advanced Cutaneous Squamous Cell Carcinoma: Biology, Immunotherapy, and Evolving Prognostic Factors.Biomedicines · 2025Review
- Cross-ancestral GWAS identifies 29 variants across head and neck cancer subsites.Nature communications · 2025Article
- Isoform-level analyses of 6 cancers uncover extensive genetic risk mechanisms undetected at the gene-level.British journal of cancer · 2025Article
- Analysis of genomic traits of oral and laryngeal cancer: A comparative study.Bioinformation · 2025Article
- Genetic, clinical, lifestyle and sociodemographic risk factors for head and neck cancer: A UK Biobank study.PloS one · 2025Article
- Potentially functional variants of CHMP4A and PANX1 in the pyroptosis-related pathway predict survival of patients with non-oropharyngeal head and neck squamous cell carcinoma.Molecular carcinogenesis · 2024Article
- Causal inference of the effect of blood proteome on the risk of head and neck cancer: two-sample Mendelian randomization.Discover oncology · 2024Article
- TGF-β1 and TGF-βR1 variants are associated with clinical outcomes in smoking-related head and neck cancer patients treated with chemoradiation through modulating microRNA-mediated regulation.Cancer immunology, immunotherapy : CII · 2024Article
- Polygenic risk score-based phenome-wide association study of head and neck cancer across two large biobanks.BMC medicine · 2024Article
- Segregation of nascent GPCRs in the ER-to-Golgi transport by CCHCR1 via direct interaction.Journal of cell science · 2024Article
- Towards system genetics analysis of head and neck squamous cell carcinoma using the mouse model, cellular platform, and clinical human data.Animal models and experimental medicine · 2023Review
- Single-nucleotide polymorphism at alcohol dehydrogenase 1B: A susceptible gene marker in oro-/hypopharyngeal cancers from genome-wide association study.Cancer medicine · 2023Article
- Causal relationship between gut microbiota and cancers: a two-sample Mendelian randomisation study.BMC medicine · 2023Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Sanjay SheteDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas. sshete@mdanderson.org qingyi.wei@duke.edu.
Hongliang Liu *Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina.
Jian Wang *Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Robert Yu *Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Erich M SturgisDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Guojun LiDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Kristina R DahlstromDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.ORCID 0000-0002-8116-9558
Zhensheng LiuDuke Cancer Institute, Duke University Medical Center, Durham, North Carolina.
Christopher I AmosThe Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, Texas.ORCID 0000-0002-8540-7023
Qingyi WeiDuke Cancer Institute, Duke University Medical Center, Durham, North Carolina. sshete@mdanderson.org qingyi.wei@duke.edu.ORCID 0000-0002-3845-9445
The University of Texas MD Anderson Cancer Center · USDuke University · USBaylor College of Medicine · US
Funding
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8MWomen's Cancer Research ProgramP30CA014236 · NCI · DUKE UNIVERSITY · PI JOHN N. NORTON · 1985 to 2026
$174.8MSubject CollectionU10AA008401 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI JAY Arnold TISCHFIELD · 1989 to 2026
$162.7MVECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHN C. BYRD · 1988 to 2026
$158.0MWILD TYPE P53-BASED ADJUVANT IMMUNOTHERAPY FOR SCCHNP50CA097190 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Greg M. Delgoffe · 2004 to 2026
$49.6MTargeting the p53 pathway for reversal of oral premalignancyP50CA097007 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MILLS, GORDON B. · 2002 to 2012
$26.1MJH/CIDR Genotyping for Genome-Wide Association StudiesU01HG004438 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2007 to 2011
$24.2MUT M.D. Anderson Cancer Center SPORE in MelanomaP50CA093459 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI GRIMM, ELIZABETH A · 2004 to 2014
$23.7MThe Collaborative Genetic Study of Nicotine DependenceP01CA089392 · NCI · WASHINGTON UNIVERSITY · PI BIERUT, LAURA J. · 2001 to 2012
$17.3MTransdisciplinary Research in Cancer of the Lung (TRICL)U19CA148127 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI AMOS, CHRISTOPHER I., LE MARCHAND, LOIC · 2010 to 2014
$10.9MGenome Wide Association Coordinating CenterU01HG004446 · NHGRI · UNIVERSITY OF WASHINGTON · PI WEIR, BRUCE S. · 2007 to 2011
$6.6MMolecular Epidemiology of Head and Neck CancerR01ES011740 · NIEHS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI WEI, QINGYI · 2001 to 2012
$6.3MNCI NIH HHS P01 CA089392NCI NIH HHS P30 CA014236NCI NIH HHS P30 CA016672NCI NIH HHS P30 CA047904NCI NIH HHS P50 CA093459NCI NIH HHS P50 CA097007NCI NIH HHS P50 CA097190NCI NIH HHS R01 CA090731NCI NIH HHS R01 CA092039NCI NIH HHS R01 CA100264NCI NIH HHS R01 CA131274NCI NIH HHS R01 CA131324NCI NIH HHS R01 CA133996NCI NIH HHS U19 CA148127NHGRI NIH HHS U01 HG004422NHGRI NIH HHS U01 HG004438NHGRI NIH HHS U01 HG004446NIAAA NIH HHS U10 AA008401NIDA NIH HHS R01 DA013423NIDCR NIH HHS R01 DE022891NIEHS NIH HHS R01 ES011740
Abstract
To identify genetic variants for risk of squamous cell carcinoma of the head and neck (SCCHN), we conducted a two-phase genome-wide association study consisting of 7,858,089 SNPs in 2,171 cases and 4,493 controls of non-Hispanic white, of which, 434,839 typed and 7,423,250 imputed SNPs were used as the discovery. SNPs with
Indexed as
Genetic Predisposition to DiseaseAdolescentAdultAgedAged, 80 and overComputational BiologyFemaleGenome-Wide Association StudyHLA-DQ beta-ChainsHumansIntracellular Signaling Peptides and ProteinsLaryngeal NeoplasmsMaleMiddle AgedPolymorphism, Single NucleotideQuantitative Trait LociCCHCR1 protein, humanHLA-DQB1 antigenHLA-DQ beta-ChainsIntracellular Signaling Peptides and Proteins
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