Evidence map›Paper›PMID 32276963›Full record

ArticleMolecular pharmacology2020

CXL146, a Novel 4

Tengfei Bian, Abderrahmane Tagmount, Christopher Vulpe, Kavitha Chandagirikoppal Vijendra, Chengguo Xing

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Tengfei BianDepartment of Medicinal Chemistry, College of Pharmacy (T.B., K.C.V., C.X.) and Department of Physiological Sciences, College of Veterinary Medicine (A.T., C.V.), University of Florida, Gainesville, Florida; and Department of Chemistry, Government College for Women Mandya, University of Mysore, Karnataka, India (K.C.V.).
Abderrahmane TagmountDepartment of Medicinal Chemistry, College of Pharmacy (T.B., K.C.V., C.X.) and Department of Physiological Sciences, College of Veterinary Medicine (A.T., C.V.), University of Florida, Gainesville, Florida; and Department of Chemistry, Government College for Women Mandya, University of Mysore, Karnataka, India (K.C.V.).
Christopher VulpeDepartment of Medicinal Chemistry, College of Pharmacy (T.B., K.C.V., C.X.) and Department of Physiological Sciences, College of Veterinary Medicine (A.T., C.V.), University of Florida, Gainesville, Florida; and Department of Chemistry, Government College for Women Mandya, University of Mysore, Karnataka, India (K.C.V.).
Kavitha Chandagirikoppal VijendraDepartment of Medicinal Chemistry, College of Pharmacy (T.B., K.C.V., C.X.) and Department of Physiological Sciences, College of Veterinary Medicine (A.T., C.V.), University of Florida, Gainesville, Florida; and Department of Chemistry, Government College for Women Mandya, University of Mysore, Karnataka, India (K.C.V.) kavitha.cv@gmail.com.
Chengguo XingDepartment of Medicinal Chemistry, College of Pharmacy (T.B., K.C.V., C.X.) and Department of Physiological Sciences, College of Veterinary Medicine (A.T., C.V.), University of Florida, Gainesville, Florida; and Department of Chemistry, Government College for Women Mandya, University of Mysore, Karnataka, India (K.C.V.) chengguoxing@cop.ufl.edu.
University of Mysore · INFlorida College · US

Funding

Mechanisms of Anticancer Agents Selective against Drug Resistant LeukemiaR01CA163864 · NCI · UNIVERSITY OF MINNESOTA · PI XING, CHENGGUO · 2012 to 2016
$1.5M
NCI NIH HHS R01 CA163864
6 · The paper itself

Abstract

The 78-kDa glucose-regulated protein (GRP78), an endoplasmic reticulum (ER) chaperone, is a master regulator of the ER stress. A number of studies revealed that high levels of GRP78 protein in cancer cells confer multidrug resistance (MDR) to therapeutic treatment. Therefore, drug candidate that reduces GRP78 may represent a novel approach to eliminate MDR cancer cells. Our earlier studies showed that a set of 4

Indexed as

Antineoplastic AgentsBenzopyransCell Line, TumorCRISPR-Cas SystemsDrug Resistance, MultipleDrug Resistance, NeoplasmDrug Screening Assays, AntitumorEndoplasmic Reticulum Chaperone BiPHeat-Shock ProteinsHL-60 CellsHumansMitoxantroneAntineoplastic AgentsBenzopyransCXL146Endoplasmic Reticulum Chaperone BiPHeat-Shock ProteinsHSPA5 protein, humanMitoxantrone

Identifiers

PMID32276963
PMCPMC7237868
OpenAlexW3015705232

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.