Evidence map›Paper›PMID 32276877›Full record

ArticleBrazilian journal of physical therapy

Resistance training decreases matrix metalloproteinase-2 activity in quadriceps tendon in a rat model of osteoarthritis.

Fernando Augusto Vasilceac, Rita de Cássia Marqueti, Ivo Vieira de Sousa Neto, Dahan da Cunha Nascimento, Mariana Carvalho de Souza, João Luiz Quaglioti Durigan, Stela Márcia Mattiello

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PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of physical therapy. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Fernando Augusto VasilceacGraduate Program of Physical Therapy, Universidade Federal de São Carlos (UFSCar), São Carlos, São Paulo, Brazil.
Rita de Cássia MarquetiGraduate Program of Sciences and Technology of Health, Universidade de Brasília (UnB), Brasília, Distrito Federal, Brazil; Graduate Program in Rehabilitation Sciences, Universidade de Brasília (UnB), Brasília, Distrito Federal, Brazil. Electronic address: marqueti@gmail.com.
Ivo Vieira de Sousa NetoGraduate Program of Sciences and Technology of Health, Universidade de Brasília (UnB), Brasília, Distrito Federal, Brazil.
Dahan da Cunha NascimentoGraduate Program of Physical Education, Universidade Católica de Brasília (UCB), Brasília, Distrito Federal, Brazil; Department of Physical Education, Centro Universitário do Distrito Federal, Brasília, Distrito Federal, Brazil.
Mariana Carvalho de SouzaGraduate Program of Physical Therapy, Universidade Federal de São Carlos (UFSCar), São Carlos, São Paulo, Brazil.
João Luiz Quaglioti DuriganGraduate Program of Sciences and Technology of Health, Universidade de Brasília (UnB), Brasília, Distrito Federal, Brazil; Graduate Program in Rehabilitation Sciences, Universidade de Brasília (UnB), Brasília, Distrito Federal, Brazil.
Stela Márcia MattielloGraduate Program of Physical Therapy, Universidade Federal de São Carlos (UFSCar), São Carlos, São Paulo, Brazil.
Universidade de Brasília · BRUniversidade Federal de São Carlos · BRUniversidade Católica de Brasília · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOsteoarthritis (OA) is a degenerative disease that induces peri-articular tissue degradation. OA induces an imbalance between synthesis and degradation of the extracellular matrix components in favor of catabolic events, promoting pathological remodeling and involving degradative enzymes, such as matrix metalloproteinases (MMPs).

objectiveThis study aimed to investigate the effects of 8-weeks resistance training (RT) on MMP-2 activity in the quadriceps tendon and patellar tendon in an OA model.

methodsTwenty-four Wistar rats were randomly divided into six groups: Control, Exercise, Sham, Sham with Exercise, OA, and OA with Exercise (OAE). The OA model was performed by anterior cruciate ligament transection surgery on the left knee. The 8-week RT consisted of climbing a 1.1-m vertical ladder three times per week with progressive weights secured to the animals' tails. MMP-2 activity was analyzed by zymography.

resultsThe OAE group displayed lower pro, intermediate, and active MMP-2 activity in the quadriceps tendon compared with the OA group (p<0.05). For the patellar tendon, there was no significant difference between the OAE group compared with the other groups (p>0.05) for pro, intermediate, and active MMP-2 activity. Moreover, MMP-2 activity differed between tissues, the OA and OAE groups presented lower pro, intermediate, and active MMP-2 activity in the quadriceps tendon compared to the patellar tendon.

conclusionRT induced down-regulated MMP-2 activity in the quadriceps tendon. RT is a potential therapeutic approach to minimize the deleterious effects of extracellular matrix degeneration.

Indexed as

Resistance TrainingAnimalsMatrix Metalloproteinase 2OsteoarthritisQuadriceps MuscleRatsRats, WistarTendonsMatrix Metalloproteinase 2Extracellular matrixGelatinasesOsteoarthritisPeri jointsPhysical trainingRehabilitation

Identifiers

PMID32276877
PMCPMC7990731
OpenAlexW3012357122

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.