Evidence map›Paper›PMID 32276627›Full record

ArticleJournal of neuroengineering and rehabilitation2020

Sum of phase-shifted sinusoids stimulation prolongs paralyzed muscle output.

Kristen Gelenitis, Max Freeberg, Ronald Triolo

Open access · goldAbstract readCase Reports
In one paragraph

Article in Journal of neuroengineering and rehabilitation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Effectiveness of Neuromuscular Electrical Stimulation in Preventing Venous Thromboembolism: A Meta-Analysis Based on Randomized Controlled Trials.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Kristen GelenitisDepartment of Biomedical Engineering, Case Western Reserve University, 10,900 Euclid Avenue, Cleveland, OH, 44106, USA. kxg277@case.edu.
Max FreebergDepartment of Biomedical Engineering, Case Western Reserve University, 10,900 Euclid Avenue, Cleveland, OH, 44106, USA.
Ronald TrioloDepartment of Biomedical Engineering, Case Western Reserve University, 10,900 Euclid Avenue, Cleveland, OH, 44106, USA.
Case Western Reserve University · USLouis Stokes Cleveland VA Medical Center · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4M
Integrated Neural Engineering and Rehabilitation Training ProgramT32EB004314 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI Jeffrey R Capadona, Robert F. Kirsch · 2004 to 2026
$6.1M
NEUROPROSTHESIS PERFORMANCE - NERVE CUFF ELECTRODESR01EB001889 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI TRIOLO, RONALD J, TYLER, DUSTIN J. · 2003 to 2017
$5.9M
NRSA Training CoreTL1TR002549 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI HARDING, CLIFFORD V · 2018 to 2022
$2.9M
NCATS NIH HHS TL1 TR002549NIBIB NIH HHS R01 EB001889NIBIB NIH HHS T32 EB004314NIGMS NIH HHS T32 GM007250RRD VA I01 RX001204
6 · The paper itself

Abstract

Neuroprostheses that activate musculature of the lower extremities can enable standing and movement after paralysis. Current systems are functionally limited by rapid muscle fatigue induced by conventional, non-varying stimulus waveforms. Previous work has shown that sum of phase-shifted sinusoids (SOPS) stimulation, which selectively modulates activation of individual motor unit pools (MUPs) to lower the duty cycle of each while maintaining a high net muscle output, improves joint moment maintenance but introduces greater instability over conventional stimulation. In this case study, implementation of SOPS stimulation with a real-time feedback controller successfully decreased joint moment instability and further prolonged joint moment output with increased stimulation efficiency over open-loop approaches in one participant with spinal cord injury. These findings demonstrate the potential for closed-loop SOPS to improve functionality of neuroprosthetic systems.

Indexed as

AdultElectric Stimulation TherapyFeedbackHumansKnee JointMaleMovementMuscle FatigueMuscle, SkeletalParalysisSpinal Cord InjuriesDuty cycleFatigueFeedback controlNeuroprosthesesParalysisStimulation

Identifiers

PMID32276627
PMCPMC7149858
OpenAlexW3016012812

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.