ArticleBMC gastroenterology2020
The significance of preoperative serum carcinoembryonic antigen levels in the prediction of lymph node metastasis and prognosis in locally advanced gastric cancer: a retrospective analysis.
Article in BMC gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 27 citations in OpenAlex.
- A preoperative scoring system to predict lymph node metastasis in intrahepatic cholangiocarcinoma.Hepatology international · 2023Trial
- A liquid biopsy-based multi-methylation marker panel for minimally invasive gastric cancer screening.Clinical epigenetics · 2026Article
- Editorial: Altered metabolic traits in gastro-intestinal tract cancers, volume II.Frontiers in endocrinology · 2026Article
- Blood ctDNA-specific markers predict the risk of peritoneal metastasis for advanced gastric cancer.Discover oncology · 2025Article
- Accuracy of dual-contrast gastrointestinal ultrasonography in predicting lymph node metastasis in older adults with gastric cancer.World journal of gastrointestinal oncology · 2025Article
- Development of the G-Risk scoring system utilizing inflammatory and tumor biomarkers to improve prognostic accuracy in gastric cancer patients without lymphovascular invasion.European journal of medical research · 2025Article
- Diagnostic value of systemic immune-inflammation index and prognostic nutritional index combined with CEA in gastric cancer with lymph node metastasis.Frontiers in endocrinology · 2025Article
- Risk factors and clinical significance of lower perigastric lymph node metastases in Siewert type II and III esophagogastric junction adenocarcinoma: a retrospective cohort study.Surgical endoscopy · 2024Article
- Preoperatively predicting the lymph node metastasis and prognosis for gastric cancer patients.Scientific reports · 2024Article
- Establishment and validation of a nomogram model for early diagnosis of gastric cancer: a large-scale cohort study.Frontiers in oncology · 2024Article
- Clinical association between coagulation indicators and bone metastasis in patients with gastric cancer.World journal of gastrointestinal oncology · 2023Article
- Prolonged hyperthermic intraperitoneal chemotherapy duration with 90 minutes cisplatin might increase overall survival in gastric cancer patients with peritoneal metastases.World journal of gastroenterology · 2023Article
- Gastric morphological type: A supplementary addition for the evaluation of gastric cancer.Oncology letters · 2023Article
- Exosomal hsa-let-7g-3p and hsa-miR-10395-3p derived from peritoneal lavage predict peritoneal metastasis and the efficacy of neoadjuvant intraperitoneal and systemic chemotherapy in patients with gastric cancer.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2023Article
- Clinicopathological characteristics and treatment outcome of resectable gastric cancer patients with small para-aortic lymph node.Frontiers in oncology · 2023Article
- Study on the expression of c-Met in gastric cancer and its correlation with preoperative serum tumor markers and prognosis.World journal of surgical oncology · 2022Article
- Prognostic significance of serum tumor marker normalization in the perioperative period for patients with advanced gastric cancer.Annals of translational medicine · 2022Article
- 'FLARE' of tumor marker in advanced gastric cancer treated with first-line systemic therapy.Therapeutic advances in gastroenterology · 2022Article
- Model based on preoperative clinical characteristics to predict lymph node metastasis in patients with gastric cancer.Frontiers in surgery · 2022Article
- Clinical value of serum biomarkers CA153, CEA, and white blood cells in predicting sentinel lymph node metastasis of breast cancer.International journal of clinical and experimental pathology · 2020Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundIn this study, we aimed to investigate the preoperative serum carcinoembryonic antigen (CEA) in the diagnosis of positive lymph node metastasis (LNM), and to evaluated the relationship between CEA and survival in patients with locally advanced gastric cancer (LAGC).
methodsThe significance of the preoperative serum CEA level for the diagnose of LAGC and prediction of LNM was determined using the receiver operating characteristic (ROC) curve. The areas under the ROC of CEA were compared with those of other tumor markers or imaging examination including CT and MRI. Logistic regression was utilized to identify the risk factors predicting positive LNM. Independent prognosis factors were evaluated using univariate and multivariate COX regression analyses.
resultsThe ROC curves showed that the AUCs of CEA, CA199, and CA125 for diagnosing LAGC were 0.727, 0.594, and 0.566. When used to predict LNM, the AUC of CEA, CA199 and CA125 were 0.696, 0.531, and 0.588. Logistic regression analysis demonstrated that preoperative serum CEA were significantly associated with positive LNM. On combining imaging examination with CEA, the sensitivity and specificity were 85.3 and 79.4%, respectively, with the AUC equal to 0.853. The combination of CEA and imaging examination preformed the highest levels of AUC and sensitivity for diagnosing LNM, which is significantly higher than using either of them alone. Although patients with abnormal CEA have a poor prognosis, two models of multivariate analysis showed that CEA was not the independent prognosis factor for survival.
conclusionsCEA can be used to diagnose gastric cancer and determine whether it has LNM. Moreover, combined with CEA could improve the diagnostic sensitivity of imaging examination for lymph node involvement.
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