ArticlePharmaceutics2020
Improved Diabetic Wound Healing by EGF Encapsulation in Gelatin-Alginate Coacervates.
Article in Pharmaceutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 46 citations in OpenAlex.
- Biomimetic Coacervate Coatings: From Phase Separation Fundamentals to Advanced Biomedical Applications.Biomimetics (Basel, Switzerland) · 2026Review
- Cell migration in diabetic wound healing: Molecular mechanisms and therapeutic strategies (Review).International journal of molecular medicine · 2025Review
- Orientin promotes diabetic wounds healing by suppressing ferroptosis via activation of the Nrf2/GPX4 pathway.Food science & nutrition · 2024Article
- Adipose-derived stem cells derived decellularized extracellular matrix enabled skin regeneration and remodeling.Frontiers in bioengineering and biotechnology · 2024Article
- Advanced polymer hydrogels that promote diabetic ulcer healing: mechanisms, classifications, and medical applications.Biomaterials research · 2023Review
- Therapeutic role of growth factors in treating diabetic wound.World journal of diabetes · 2023Review
- Biopolymer-Based Wound Dressings with Biochemical Cues for Cell-Instructive Wound Repair.Polymers · 2022Review
- Resveratrol accelerates wound healing by inducing M2 macrophage polarisation in diabetic mice.Pharmaceutical biology · 2022Article
- Stability Enhancement of Freeze-Dried Gelatin/Alginate Coacervates for bFGF Delivery.Pharmaceutics · 2022Article
- Topical Application of Chinese Formula Yeliangen Promotes Wound Healing in Streptozotocin-Induced Diabetic Rats.Journal of diabetes research · 2022Article
- Recent advances of the nanocomposite hydrogel as a local drug delivery for diabetic ulcers.Frontiers in bioengineering and biotechnology · 2022Review
- Gelatin-Alginate Coacervates Optimized by DOE to Improve Delivery of bFGF for Wound Healing.Pharmaceutics · 2021Article
- [Research advances on the application of biocompatible materials in treating diabetic wounds].Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns · 2021Review
- Synergistic Effect of Biomaterial and Stem Cell for Skin Tissue Engineering in Cutaneous Wound Healing: A Concise Review.Polymers · 2021Review
- Wound-Healing Potential ofAdvances in pharmacological and pharmaceutical sciences · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Topical imageplication of epidermal growth fctor (EGF) has been used to accelerate diabetic foot ulcers but with limited efficacy. In this study, we selected a complex coacervate (EGF-Coa) composed of the low molecular weight gelatin type A and sodium alginate as a novel delivery system for EGF, based on encapsulation efficiency and protection of EGF from protease. EGF-Coa enhanced in vitro migration of keratinocytes and accelerated wound healing in streptozotocin-induced diabetic mice with increased granulation and re-epithelialization. While diabetic wound sites without treatment showed downward growth of hyperproliferative epidermis along the wound edges with poor matrix formation, EGF-Coa treatment recovered horizontal migration of epidermis over the newly deposited dermal matrix. EGF-Coa treatment also resulted in reduced levels of proinflammatory cytokines IL-1, IL-6, and THF-α. Freeze-dried coacervates packaged in aluminum pouches were stable for up to 4 months at 4 and 25 °C in terms of appearance, purity by RP-HPLC, and in vitro release profiles. There were significant physical and chemical changes in relative humidity above 33% or at 37 °C, suggesting the requirement for moisture-proof packaging and cold chain storage for long term stability. We propose low molecular weight gelatin type A and sodium alginate (LWGA-SA) coacervates as a novel EGF delivery system with enhanced efficacy for chronic wounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.