Evidence map›Paper›PMID 32276238›Full record

ArticleBehaviour research and therapy2020

Changes in functional connectivity with cognitive behavioral therapy for social anxiety disorder predict outcomes at follow-up.

Christina F Sandman, Katherine S Young, Lisa J Burklund, Darby E Saxbe, Matthew D Lieberman, Michelle G Craske

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Behaviour research and therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Trial
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  4. Article
  5. Review
  6. Neurodevelopmental Pathways from Temperamental Fear to Anxiety.Current topics in behavioral neurosciences · 2025
    Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Molecular and neurocircuitry mechanisms of social avoidance.Cellular and molecular life sciences : CMLS · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Christina F SandmanDepartment of Psychology, University of California, 405 Hilgard Avenue, Los Angeles, CA, 90095-1563, USA.
Katherine S YoungSocial, Genetic and Developmental Psychiatry Centre, King's College London, Memory Lane, Camberwell, London, UK.
Lisa J BurklundDepartment of Psychology, University of California, 405 Hilgard Avenue, Los Angeles, CA, 90095-1563, USA.
Darby E SaxbeDepartment of Psychology, University of Southern California, Los Angeles, CA, USA.
Matthew D LiebermanDepartment of Psychology, University of California, 405 Hilgard Avenue, Los Angeles, CA, 90095-1563, USA; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, USA.
Michelle G CraskeDepartment of Psychology, University of California, 405 Hilgard Avenue, Los Angeles, CA, 90095-1563, USA; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, USA. Electronic address: MCraske@mednet.ucla.edu.
University of California, Los Angeles · USKing's College London · GBNeurobehavioral Systems · USUniversity of Southern California · US

Funding

Neural mediators of behavior therapy for anxietyR21MH081299 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CRASKE, MICHELLE G · 2008 to 2009
$402k
NIMH NIH HHS R21 MH081299
6 · The paper itself

Abstract

Approximately half of individuals with Social Anxiety Disorder (SAD) treated with psychological intervention do not achieve clinically significant improvement or retain long-term gains. Neurobiological models of SAD propose that disruptions in functioning of amygdala-prefrontal circuitry is implicated in short-term treatment response. However, whether treatment-related changes in functional connectivity predict long-term well-being after psychotherapy is unknown. Patients with SAD completed an incidental emotion regulation task during fMRI before and after treatment with cognitive behavioral therapy or acceptance and commitment therapy (n = 23, collapsed across groups). Psychophysiological interaction analyses using amygdala seed regions were conducted to assess changes in functional connectivity from pre-to post-treatment that predicted symptom change from 6 to 12-month follow-up. Negative change (i.e., greater inverse/weaker positive) in amygdala connectivity with the dorsomedial prefrontal cortex (dmPFC) and dorsal anterior cingulate cortex (dACC) predicted greater symptom reduction during follow-up. Positive change in amygdala connectivity with the cerebellum, fusiform gyrus, and pre-central and post-central gyri predicted less symptom reduction (e.g., no change or worsening). Results suggest that strengthened amygdala connectivity with regulatory regions may promote better long-term outcomes, whereas changes with visual and sensorimotor regions may represent sensitization to emotion-related cues, conferring poorer outcomes. Clinical implications for treatment personalization are discussed, should effects replicate in larger samples.

Indexed as

AdultAmygdalaBrainCognitive Behavioral TherapyEmotional RegulationFemaleGyrus CinguliHumansMaleNeural PathwaysPhobia, SocialPrefrontal CortexPrognosisSensorimotor CortexTreatment OutcomeVisual CortexAmygdalaEmotion regulationfMRILong-term treatment responsePrefrontal cortex

Identifiers

PMID32276238
PMCPMC7329578
OpenAlexW3013261764

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.