ArticleNeurobiology of learning and memory2020
Dorsomedial prefrontal cortex and hippocampus represent strategic context even while simultaneously changing representation throughout a task session.
Article in Neurobiology of learning and memory, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Rhythmic modulation of dorsal hippocampus across distinct behavioral timescales during spatial set-shifting.bioRxiv : the preprint server for biology · 2025Article
- Mental Time Travel: A Retrospective.Hippocampus · 2025Review
- Environmental complexity modulates information processing and the balance between decision-making systems.Neuron · 2024Article
- Flexible decision-making is related to strategy learning, vicarious trial and error, and medial prefrontal rhythms during spatial set-shifting.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- A Double Hit of Social and Economic Stress in Mice Precipitates Changes in Decision-Making Strategies.Biological psychiatry · 2024Article
- Optimizing electrode placement for transcranial direct current stimulation in nonsuperficial cortical regions: a computational modeling study.Biomedical engineering letters · 2024Article
- Theta Oscillations Support Prefrontal-hippocampal Interactions in Sequential Working Memory.Neuroscience bulletin · 2024Article
- Optogenetic disruption of the prelimbic cortex alters long-term decision strategy but not valuation on a spatial delay discounting task.Neurobiology of learning and memory · 2023Article
- Computational validity: using computation to translate behaviours across species.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Dynamic and heterogeneous neural ensembles contribute to a memory engram.Current opinion in neurobiology · 2021Review
- Involvement of Mitophagy in Aluminum Oxide Nanoparticle-Induced Impairment of Learning and Memory in Mice.Neurotoxicity research · 2021Article
- Potential roles of the rodent medial prefrontal cortex in conflict resolution between multiple decision-making systems.International review of neurobiology · 2021Review
- Genetic Depletion of BDNF Impairs Extinction Learning of a Spatial Appetitive Task in the Presence or Absence of the Acquisition Context.Frontiers in behavioral neuroscience · 2021Article
- Spatial encoding in dorsomedial prefrontal cortex and hippocampus is related during deliberation.Hippocampus · 2020Article
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2 authors.
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Abstract
Dorsomedial prefrontal cortex (dmPFC) and hippocampus (HPC) are thought to play complementary roles in a spatial working memory and decision-making network, where spatial information from HPC informs representations in dmPFC, and contextual information from dmPFC biases how HPC recalls that information. We recorded simultaneously from neural ensembles in rodent dmPFC and HPC as rats performed a rule-switching task, and found that ensembles in dmPFC and HPC simultaneously encoded task contingencies and other time-varying information. While ensembles in HPC transitioned to represent new contingencies at the same time as rats updated their strategies to be consistent with the new contingency, dmPFC ensembles transitioned earlier. Neural representations of other time-varying information also changed faster in dmPFC than in HPC. Our results suggest that HPC and dmPFC represent contingencies while simultaneously representing other information which changes over time, and that this contextual information is integrated into hippocampal representations more slowly than in dmPFC.
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