ArticleNeuroImage2020
Sex differences associated with corpus callosum development in human infants: A longitudinal multimodal imaging study.
Article in NeuroImage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Sex differences in brain homotopic co-activations: a meta-analytic study.Brain structure & function · 2022Pooled it
- WhiFuN: A toolbox to map the white matter functional networks of the human brain.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Sex Differences in Human Brain Structure at Birth.Biology of sex differences · 2024Article
- Surface-based morphometry of the corpus callosum in young children of ages 1-5.Human brain mapping · 2024Article
- White matter microstructure, traumatic brain injury, and disruptive behavior disorders in girls and boys.Frontiers in neuroscience · 2024Article
- Corpus Callosum Volumes in Children with Autism Spectrum Disorders: Sex-Associated Differences.Journal of autism and developmental disorders · 2023Article
- Exploring interhemispheric connectivity using the directional tract density patterns of the corpus callosum.Neuroimage. Reports · 2023Article
- Insights into morphometry and topography of corpus callosum among Indians.Bioinformation · 2023Article
- Allometry in the corpus callosum in neonates: Sexual dimorphism.Human brain mapping · 2022Article
- Individual variability in the nonlinear development of the corpus callosum during infancy and toddlerhood: a longitudinal MRI analysis.Brain structure & function · 2022Article
- Cerebral White Matter Myelination and Relations to Age, Gender, and Cognition: A Selective Review.Frontiers in human neuroscience · 2021Review
- Infant and Child MRI: A Review of Scanning Procedures.Frontiers in neuroscience · 2021Review
- Assessing oligodendrocyte and myelin alterations following absence seizures in a rat model ofBrain and neuroscience advancesArticle
Corrections and comments
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Authors and funding
17 authors at 9 institutions in 1 country.
Funding
Abstract
The corpus callosum (CC) is the largest connective pathway in the human brain, linking cerebral hemispheres. There is longstanding debate in the scientific literature whether sex differences are evident in this structure, with many studies indicating the structure is larger in females. However, there are few data pertaining to this issue in infancy, during which time the most rapid developmental changes to the CC occur. In this study, we examined longitudinal brain imaging data collected from 104 infants at ages 6, 12, and 24 months. We identified sex differences in brain-size adjusted CC area and thickness characterized by a steeper rate of growth in males versus females from ages 6-24 months. In contrast to studies of older children and adults, CC size was larger for male compared to female infants. Based on diffusion tensor imaging data, we found that CC thickness is significantly associated with underlying microstructural organization. However, we observed no sex differences in the association between microstructure and thickness, suggesting that the role of factors such as axon density and/or myelination in determining CC size is generally equivalent between sexes. Finally, we found that CC length was negatively associated with nonverbal ability among females.
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Registered trials
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