ArticleNeuroImage2020
Gamma oscillations weaken with age in healthy elderly in human EEG.
Article in NeuroImage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06284720 (Transcranial Alternating Current Stimulation for the Improvement of Episodic Memory in Healthy Older Adults), which is not on this map. Cited by 56 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Transcranial Alternating Current Stimulation for the Improvement of Episodic Memory in Healthy Older Adults
Who cites it
56 citing papers in PubMed, 1 synthesis or guideline pooled it, 120 citations in OpenAlex.
- Developmental and aging trajectories of 40-Hz auditory steady-state responses: A systematic review across the human lifespan.Developmental cognitive neuroscience · 2026Pooled it
- Individual neural dynamics of successful Gamma neuromodulation through EEG-neurofeedback in the aging brain.Scientific reports · 2025Trial
- Robust and replicable effects of ageing on resting-state brain electrophysiology measured with MEG.eLife · 2026Article
- Association of glymphatic function with 40-Hz neural oscillations, systemic metabolic markers, and cognitive performance in healthy aging adults: An EEG and MRI study.Translational psychiatry · 2026Article
- Restoration of gamma center frequency via personalized entrainment marks cognitive preservation in early Alzheimer's disease.GeroScience · 2026Article
- Normative modeling of MEG brain oscillations across the human lifespan.Communications biology · 2026Article
- Personalized audiovisual gamma stimulation enhances neural connectivity and entrainment beyond fixed 40 Hz protocols.Frontiers in neuroscience · 2026Article
- Article
- Review
- Resting-state EEG gamma power predicts immediate and delayed recall in healthy adults.Cognitive neurodynamics · 2025Article
- Electroencephalogram Gamma Band Power Correlates with Anhedonia in a Community Sample.Journal of personalized medicine · 2025Article
- Mapping EEG Metrics to Human Affective and Cognitive Models: An Interdisciplinary Scoping Review from a Cognitive Neuroscience Perspective.Biomimetics (Basel, Switzerland) · 2025Review
- Investigating Gamma Frequency Band PSD in Alzheimer's Disease Using qEEG from Eyes-Open and Eyes-Closed Resting States.Journal of clinical medicine · 2025Article
- Article
- Neural biomarkers of age-related memory change.Psychology and aging · 2025Article
- Age-Related Electroencephalographic Delta and Alpha Oscillations During Sedation with Target-Controlled Propofol Infusion.Journal of clinical medicine · 2025Article
- Delayed Accumulation of Inhibitory Input Explains Gamma Frequency Variation with Changing Contrast in an Inhibition Stabilized Network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Age predicts peak gamma frequency and N1 amplitude of visual evoked potential.BMC neuroscience · 2025Article
- Preclinical insights into gamma-tACS: foundations for clinical translation in neurodegenerative diseases.Frontiers in neuroscience · 2025Review
- Healthy aging is associated with altered visual gamma band onset and offset responses.Imaging neuroscience (Cambridge, Mass.) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Gamma rhythms (~20-70 Hz) are abnormal in mental disorders such as autism and schizophrenia in humans, and Alzheimer's disease (AD) models in rodents. However, the effect of normal aging on these oscillations is unknown, especially for elderly subjects in whom AD is most prevalent. In a first large-scale (236 subjects; 104 females) electroencephalogram (EEG) study on gamma oscillations in elderly subjects (aged 50-88 years), we presented full-screen visual Cartesian gratings that induced two distinct gamma oscillations (slow: 20-34 Hz and fast: 36-66 Hz). Power decreased with age for gamma, but not alpha (8-12 Hz). Reduction was more salient for fast gamma than slow. Center frequency also decreased with age for both gamma rhythms. The results were independent of microsaccades, pupillary reactivity to stimulus, and variations in power spectral density with age. Steady-state visual evoked potentials (SSVEPs) at 32 Hz also reduced with age. These results are crucial for developing gamma/SSVEP-based biomarkers of cognitive decline in elderly.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.