Evidence map›Paper›PMID 32275979›Full record

ArticleChest2020

Surfactant Protein D Is Associated With Severe Pediatric ARDS, Prolonged Ventilation, and Death in Children With Acute Respiratory Failure.

Mary K Dahmer, Heidi Flori, Anil Sapru, Joseph Kohne, Heidi M Weeks, Martha A Q Curley, Michael A Matthay, Michael W Quasney, BALI and RESTORE Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network

Registry-linked trialOpen access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Chest, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00814099 (Sedation Management in Pediatric Patients With Acute Respiratory Failure), which is not on this map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00814099 nacompletednot on this map

Sedation Management in Pediatric Patients With Acute Respiratory Failure

TypeinterventionalSponsorUniversity of PennsylvaniaRan2009 to 2013Enrolled2,449ConditionsRespiratory Insufficiency, Respiratory Distress Syndrome, Newborn, Lung DiseasesArmsTeam approach to sedation management, Usual approach to sedation management
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 43 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Distinct Blood and Lung Proteins Drive Pulmonary Capillary Leak in Children With Severe Hypoxemic Respiratory Failure.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2026
    Observational
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  8. Article
  9. Review
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  11. Article
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  13. Article
  14. Article
  15. Review
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  17. Pathobiology, Severity, and Risk Stratification of Pediatric Acute Respiratory Distress Syndrome: From the Second Pediatric Acute Lung Injury Consensus Conference.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2023
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Mary K DahmerDivision of Pediatric Critical Care Medicine, Department of Pediatrics, University of Michigan, Ann Arbor, MI.
Heidi FloriDivision of Pediatric Critical Care Medicine, Department of Pediatrics, University of Michigan, Ann Arbor, MI.
Anil SapruDepartment of Pediatrics, University of California, Los Angeles, CA.
Joseph KohneDivision of Pediatric Critical Care Medicine, Department of Pediatrics, University of Michigan, Ann Arbor, MI.
Heidi M WeeksDepartment of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI.
Martha A Q CurleyDepartment of Family and Community Health (School of Nursing), Division of Anesthesia and Critical Care Medicine (Perelman School of Medicine) University of Pennsylvania, and the Research Institute, Children's Hospital of Philadelphia, Philadelphia, PA.
Michael A MatthayDepartments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, CA.
Michael W QuasneyDivision of Pediatric Critical Care Medicine, Department of Pediatrics, University of Michigan, Ann Arbor, MI. Electronic address: mquasney@med.umich.edu.
BALI and RESTORE Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network
University of Michigan–Ann Arbor · USUniversity of California, Los Angeles · USUniversity of California, San Francisco · USUniversity of Pennsylvania · US

Funding

Sedation Management in Pediatric Patients with Acute Respiratory FailureU01HL086622 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CURLEY, MARTHA AQ · 2008 to 2013
$10.0M
Sedation Management in Pediatric Patients with Acute Respiratory Failure (DCC)U01HL086649 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI WYPIJ, DAVID · 2008 to 2012
$2.0M
Genetic variation and biomarkers in children with acute lung injuryR01HL095410 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAHMER, MARY K, FLORI, HEIDI R · 2009 to 2012
$1.8M
NHLBI NIH HHS R01 HL095410NHLBI NIH HHS U01 HL086622NHLBI NIH HHS U01 HL086649
6 · The paper itself

Abstract

backgroundElevated surfactant protein D (SP-D) is a relatively specific indicator of lung injury and is associated with both acute and chronic lung disease in adults and respiratory distress syndrome in premature infants. The relationship between plasma SP-D and lung injury in children with acute respiratory failure is unclear. RESEARCH QUESTION: Is plasma SP-D associated with lung injury or outcome in children with acute respiratory failure? STUDY DESIGN AND

methodsThis was a prospective cohort study in children 2 weeks to 17 years of age with acute respiratory failure who participated in the BALI multi-center study. Analyses were done using SP-D levels in plasma from the first sample taken on either the day of intubation or one of the following 2 days. SP-D level was measured by enzyme-linked immunosorbent assay.

resultsPlasma samples from 350 patients were used in the analysis; 233 had pediatric ARDS (PARDS). SP-D levels varied across primary diagnoses (P < .001). Elevated SP-D levels were associated with severe PARDS after adjusting for age, pediatric risk of mortality III (PRISM-III), and primary diagnosis (OR = 1.02; CI = 1.01-1.04; P = .011). Multivariable analyses also indicated that elevated SP-D levels were associated with death (OR = 1.02; CI = 1.01-1.04; P = .004), duration of mechanical ventilation (P = .012), PICU length of stay (P = .019), and highest oxygenation index (P = .040). SP-D levels also correlated with age (r

interpretationElevated plasma SP-D levels are associated with severe PARDS and poor outcomes in children with acute respiratory failure. Future studies will determine whether SP-D can be used to predict the degree of lung injury or response to treatment and whether SP-D is useful in identifying PARDS endotypes.

Indexed as

AdolescentBiomarkersChildChild, PreschoolFemaleHumansInfantInfant, NewbornLength of StayMaleProspective StudiesPulmonary Surfactant-Associated Protein DRespiration, ArtificialRespiratory Distress SyndromeRespiratory Distress Syndrome, NewbornSeverity of Illness IndexBiomarkersPulmonary Surfactant-Associated Protein DARDSbiomarkercritical illnesslength of mechanical ventilationmortalityoutcomepediatric ARDSpediatricssurfactant

Identifiers

PMID32275979
PMCPMC7478231
OpenAlexW3015666641

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.