ArticleNeuropharmacology2020
Neurotensin induces hypothermia by activating both neuronal neurotensin receptor 1 and astrocytic neurotensin receptor 2 in the median preoptic nucleus.
Article in Neuropharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 40 citations in OpenAlex.
- Article
- Influence of the neurotensin signaling system on feeding and satiety.Neuropharmacology · 2025Review
- Spontaneous and pharmacologically induced hypothermia protect mice against endotoxic shock.British journal of pharmacology · 2025Article
- Article
- Decreased neurotensin induces ovulatory dysfunction via the NTSR1/ERK/EGR1 axis in polycystic ovary syndrome.Frontiers of medicine · 2025Article
- Article
- Opposing actions of co-released GABA and neurotensin on the activity of preoptic neurons and on body temperature.bioRxiv : the preprint server for biology · 2024Article
- Identification of immune-related genes and integrated analysis of immune-cell infiltration in melanoma.Aging · 2024Article
- The consumption of lard oil during pregnancy and postpartum periods has negative effects on cognitive function by altering the fatty acid profile and activating neuroinflammation via calcium signaling pathway in the maternal mice brain.Current research in food science · 2024Article
- The 46.1 Antibody Mediates Neurotensin Uptake into the CNS and the Effects Depend on the Route of Intravenous Administration.Pharmaceutics · 2022Article
- Activation of ventral tegmental area neurotensin Receptor-1 neurons promotes weight loss.Neuropharmacology · 2021Article
- Neurotensin is an anti-thermogenic peptide produced by lymphatic endothelial cells.Cell metabolism · 2021Article
- The Role of Central Neurotensin in Regulating Feeding and Body Weight.Endocrinology · 2021Review
- Review
- Strategies to identify, engineer, and validate antibodies targeting blood-brain barrier receptor-mediated transcytosis systems for CNS drug delivery.Expert opinion on drug deliveryReview
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1 author at 1 institution in 1 country.
Funding
Abstract
Neurotensin (NTS) is a neuropeptide acting as a neuromodulator in the brain and is a very potent hypothermic agent. However, the cellular mechanisms of actions are not fully understood. Here we report that NTS increases the firing rate of preoptic GABAergic neurons by activating both neurotensin receptor 1 (NTSR1) and neurotensin receptor 2 (NTSR2), expressed by neurons and astrocytes, respectively. Downstream of NTSR1 the neuropeptide activated an inward current, calcium release from intracellular stores and, postsynaptically, increased frequency and amplitude of inhibitory synaptic events. NTSR2 activation in astrocytes resulted in increased excitatory input in preoptic GABAergic neurons, an effect which was dependent upon the activation of P2X4 receptors. We also found that neuromedin N acted as a selective agonist at the NTSR1. Surprisingly, activation of both NTSR1 and NTSR2 in the median preoptic nucleus was required for activating a full hypothermic response.
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