ArticleIEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society2020
Quantifying Altered Neural Connectivity of the Stretch Reflex in Chronic Hemiparetic Stroke.
Article in IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Closed-loop rehabilitation of upper-limb dyskinesia after stroke: from natural motion to neuronal microfluidics.Journal of neuroengineering and rehabilitation · 2025Review
- Beta-Band Cortico-Muscular Phase Coherence in Hemiparetic Stroke.Biomedical signal processing and control · 2024Article
- How the Somatosensory System Adapts to the Motor Change in Stroke: A Hemispheric Shift?Medical hypotheses · 2024Article
- Perturbation-induced electromyographic activity is predictive of flexion synergy expression and a sensitive measure of post-stroke motor impairment.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2024Article
- Cross-frequency cortex-muscle interactions are abnormal in young people with dystonia.Brain communications · 2024Article
- Implications of Hemispheric Shift of Sensory Feedback during Post-stroke Motor Control on Personalized Stroke Rehabilitation.Converging clinical and engineering research on neurorehabilitation V : proceedings of the 6th International Conference on Neurorehabilitation (ICNR 2024), November 5-8, 2024, La Granja, Spain. Volume 2 · 2024Article
- Motor unit firing rate modulation is more impaired during flexion synergy-driven contractions of the biceps brachii in chronic stroke.medRxiv : the preprint server for health sciences · 2023Article
- A Method for Quantification of Stretch Reflex Excitability During Ballistic Reaching.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2023Article
- Cortical Reorganization of Early Somatosensory Processing in Hemiparetic Stroke.Journal of clinical medicine · 2022Article
- Nonlinear System Identification of Neural Systems from Neurophysiological Signals.Neuroscience · 2021Review
- Assessing the Usage of Indirect Motor Pathways Following a Hemiparetic Stroke.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2021Article
- Assessing Neural Connectivity and Associated Time Delays of Muscle Responses to Continuous Position Perturbations.Annals of biomedical engineering · 2021Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Post-stroke flexion synergy limits arm/hand function and is also linked to hyperactive stretch reflexes or spasticity. It is implicated in the increased role of indirect motor pathways following damage to direct corticospinal projections. We hypothesized that this maladaptive neuroplasticity also affects stretch reflexes. Specifically, multi-synaptic interactions in indirect motor pathways may increase nonlinear neural connectivity and time lag between stretch and reflex muscle response. Continuous position perturbations were applied to the elbow joint when eleven participants with stroke generated two levels of shoulder abduction (SABD) torques with their paretic arm to induce synergy-related spasticity. Likewise, the perturbations were applied to eleven control subjects while performing SABD and elbow flexion levels matching the synergy torques in stroke. We quantified linear and non-linear connectivity and the corresponding time lags between perturbations and muscle activity. Enhanced nonlinear connectivity with a prolonged time lag was found in stroke as compared to controls. Non-linear connectivity and time lag also increased with the expression of the flexion synergy, as induced by greater SABD load levels, in stroke. This study provides new evidence of changes in neural connectivity and long-latency time lag in the stretch reflex response post-stroke. The results suggest the contribution of indirect motor pathways to synergy-related spasticity.
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Registered trials
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