Evidence map›Paper›PMID 32275393›Full record

ArticleACS infectious diseases2020

Accelerated Discovery of Potent Fusion Inhibitors for Respiratory Syncytial Virus.

Nicole Pribut, Thomas M Kaiser, Robert J Wilson, Edgars Jecs, Zackery W Dentmon, Stephen C Pelly, Savita Sharma, Perry W Bartsch, Pieter B Burger, Soyon S Hwang and 5 more

Open access · greenAbstract read
In one paragraph

Article in ACS infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Treatment of Respiratory Viral Coinfections.Epidemiologia (Basel, Switzerland) · 2022
    Article
  5. Article
  6. Anno 2021: Which antivirals for the coming decade?Annual reports in medicinal chemistry · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Nicole PributDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.ORCID 0000-0003-0439-9162
Thomas M KaiserDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Robert J WilsonDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.ORCID 0000-0002-8344-5325
Edgars JecsDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Zackery W DentmonDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.ORCID 0000-0003-1140-9998
Stephen C PellyDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Savita SharmaDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Perry W BartschDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Pieter B BurgerDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Soyon S HwangDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Thalia LeDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Julien SourimantInstitute for Biomedical Sciences, Georgia State University, Atlanta, Georgia 30303, United States.
Jeong-Joong YoonInstitute for Biomedical Sciences, Georgia State University, Atlanta, Georgia 30303, United States.
Richard K PlemperInstitute for Biomedical Sciences, Georgia State University, Atlanta, Georgia 30303, United States.
Dennis C LiottaDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.ORCID 0000-0002-7736-7113
Emory University · USGeorgia State University · US

Funding

Identification and Pre-Clinical Evaluation of Measles Virus InhibitorsR01AI071002 · NIAID · GEORGIA STATE UNIVERSITY · PI PLEMPER, RICHARD K. · 2006 to 2022
$6.6M
Polymerase Inhibitors of Respiratory Syncytial VirusR01AI153400 · NIAID · GEORGIA STATE UNIVERSITY · PI PLEMPER, RICHARD K. · 2020 to 2024
$3.7M
Novel Therapeutics against Respiratory Syncytial Virus InfectionR01HD079327 · NICHD · GEORGIA STATE UNIVERSITY · PI PLEMPER, RICHARD K. · 2014 to 2018
$2.8M
NIAID NIH HHS R01 AI071002NIAID NIH HHS R01 AI153400NICHD NIH HHS R01 HD079327
6 · The paper itself

Abstract

A series of five benzimidazole-based compounds were identified using a machine learning algorithm as potential inhibitors of the respiratory syncytial virus (RSV) fusion protein. These compounds were synthesized, and compound

Indexed as

Antiviral AgentsRespiratory Syncytial Virus, HumanBenzimidazolesStructure-Activity RelationshipViral Fusion ProteinsAntiviral AgentsbenzimidazoleBenzimidazolesViral Fusion Proteinsbenzimidazolefusion inhibitormachine learningRSV

Identifiers

PMID32275393
PMCPMC7456560
OpenAlexW3015932283

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.