Evidence map›Paper›PMID 32275353›Full record

ArticleJournal of applied clinical medical physics2020

Automated planning through robust templates and multicriterial optimization for lung VMAT SBRT of lung lesions.

Livia Marrazzo, Chiara Arilli, Roberto Pellegrini, Pierluigi Bonomo, Silvia Calusi, Cinzia Talamonti, Marta Casati, Antonella Compagnucci, Lorenzo Livi, Stefania Pallotta

Open access · goldAbstract read
In one paragraph

Article in Journal of applied clinical medical physics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Livia MarrazzoCareggi University Hospital, Medical Physic Unit, Florence, Italy.
Chiara ArilliCareggi University Hospital, Medical Physic Unit, Florence, Italy.
Roberto PellegriniElekta AB, Stockholm, Sweden.
Pierluigi BonomoCareggi University Hospital, Radiotherapy Unit, Florence, Italy.
Silvia CalusiDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Florence, Italy.
Cinzia TalamontiCareggi University Hospital, Medical Physic Unit, Florence, Italy.
Marta CasatiCareggi University Hospital, Medical Physic Unit, Florence, Italy.
Antonella CompagnucciCareggi University Hospital, Medical Physic Unit, Florence, Italy.
Lorenzo LiviCareggi University Hospital, Radiotherapy Unit, Florence, Italy.
Stefania PallottaCareggi University Hospital, Medical Physic Unit, Florence, Italy.
Azienda Ospedaliero-Universitaria Careggi · ITUniversity of Florence · ITElekta (Sweden) · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo develop and validate a robust template for VMAT SBRT of lung lesions, using the multicriterial optimization (MCO) of a commercial treatment planning system.

methodsThe template was established and refined on 10 lung SBRT patients planned for 55 Gy/5 fr. To improve gradient and conformity a ring structure around the planning target volume (PTV) was set in the list of objectives. Ideal fluence optimization was conducted giving priority to organs at risk (OARs) and using the MCO, which further pushes OARs doses. Segmentation was conducted giving priority to PTV coverage. Two different templates were produced with different degrees of modulation, by setting the Fluence Smoothing parameter to Medium (MFS) and High (HFS). Each template was applied on 20 further patients. Automatic and manual plans were compared in terms of dosimetric parameters, delivery time, and complexity. Statistical significance of differences was evaluated using paired two-sided Wilcoxon signed-rank test.

resultsNo statistically significant differences in PTV coverage and maximum dose were observed, while an improvement was observed in gradient and conformity. A general improvement in dose to OARs was seen, which resulted to be significant for chest wall V

conclusionThe automation of the planning process for lung SBRT using robust templates and MCO was demonstrated to be feasible and more efficient.

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsRadiosurgeryRadiotherapy, Intensity-ModulatedFemaleHumansLungMaleOrgans at RiskRadiotherapy DosageRadiotherapy Planning, Computer-Assistedautomated planninglung SBRTrobust templatesVMAT

Identifiers

PMID32275353
PMCPMC7324702
OpenAlexW3015367466

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.