Evidence map›Paper›PMID 32275324›Full record

ArticleJAMA network open2020

Estimated Prevalence of Nonverbal Learning Disability Among North American Children and Adolescents.

Amy E Margolis, Jessica Broitman, John M Davis, Lindsay Alexander, Ava Hamilton, Zhijie Liao, Sarah Banker, Lauren Thomas, Bruce Ramphal, Giovanni A Salum and 5 more

Open access · goldAbstract read
In one paragraph

Article in JAMA network open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 29 citations in OpenAlex.

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  11. External Validation of BMT-Frontiers in pediatrics · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 3 countries.

Amy E MargolisDivision of Child and Adolescent Psychiatry, Department of Psychiatry, Vagelos College of Physicians & Surgeons, Columbia University Irving Medical Center, New York, New York.
Jessica BroitmanInternational Control Mastery Therapy Center, Berkeley, California.
John M DavisDepartment of Educational Psychology, California State University, Hayward.
Lindsay AlexanderCenter for the Developing Brain, Child Mind Institute, New York, New York.
Ava HamiltonDepartment of Epidemiology, Mailman School of Public Health, Columbia University Irving Medical Center, New York, New York.
Zhijie LiaoBloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, Canada.
Sarah BankerDivision of Child and Adolescent Psychiatry, Department of Psychiatry, Vagelos College of Physicians & Surgeons, Columbia University Irving Medical Center, New York, New York.
Lauren ThomasDivision of Child and Adolescent Psychiatry, Department of Psychiatry, Vagelos College of Physicians & Surgeons, Columbia University Irving Medical Center, New York, New York.
Bruce RamphalDivision of Child and Adolescent Psychiatry, Department of Psychiatry, Vagelos College of Physicians & Surgeons, Columbia University Irving Medical Center, New York, New York.
Giovanni A SalumDepartment of Psychiatry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Kathleen MerikangasIntramural Research Program, National Institute of Mental Health, Bethesda, Maryland.
Jeff GoldsmithDepartment of Biostatistics, Mailman School of Public Health, Columbia University Irving Medical Center, New York, New York.
Tomas PausBloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, Canada.
Katherine KeyesDepartment of Epidemiology, Mailman School of Public Health, Columbia University Irving Medical Center, New York, New York.
Michael P MilhamCenter for the Developing Brain, Child Mind Institute, New York, New York.
Columbia University · USColumbia University Irving Medical Center · USChild Mind Institute · USCalifornia State University System · USHolland Bloorview Kids Rehabilitation Hospital · CAHospital de Clínicas de Porto Alegre · BRNational Institute of Mental Health · USUniversity of Toronto · CA

Funding

True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATTHEW S PERZANOWSKI · 1998 to 2026
$44.7M
The Columbia Center for Children's Environmental HealthP01ES009600 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ANDREWS, HOWARD F. · 1999 to 2014
$11.2M
Population-Based Epidemiologic ResearchZIAMH002953 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MERIKANGAS, KATHLEEN R · 2016 to 2025
$7.0M
Longitudinal Discovery of Brain Developmental TrajectoriesU01MH099059 · NIMH · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI MILHAM, MICHAEL PETER · 2013 to 2017
$3.7M
The Columbia Center for Children's Environmental HealthP50ES009600 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PETERSON, BRADLEY S · 2015 to 2018
$3.4M
Prenatal Exposure to Environmental Tobacco Smoke, COVID-19- Related Psychosocial Stress, and Neurodevelopment.K23ES026239 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARGOLIS, AMY · 2016 to 2021
$767k
NIEHS NIH HHS P01 ES009600NIEHS NIH HHS P30 ES009089NIEHS NIH HHS P50 ES009600NIMH NIH HHS U01 MH099059
6 · The paper itself

Abstract

Importance: Nonverbal learning disability (NVLD) is a neurodevelopmental disorder characterized by deficits in visual-spatial processing but not in reading or verbal ability; in addition, problems in math calculation, visual executive functioning, fine-motor skills, and social skills are often present. To our knowledge, there are no population-based estimates of the prevalence of NVLD in community samples. Objective: To estimate the prevalence of the NVLD cognitive profile in 3 independent samples of children and adolescents from studies centered around brain imaging in the US and Canada. Design, Setting, and Participants: This cross-sectional study used data from 2 samples recruited from the community and overselected for children with psychiatric disorders (Healthy Brain Network [HBN], January 1, 2015, to December 31, 2019, and Nathan Kline Institute-Rockland Sample [NKI], January 1, 2011, to December 31, 2018) and 1 community-ascertained population sample (Saguenay Youth Study [SYS], January 1, 2003, to December 31, 2012) overselected for active maternal smoking during pregnancy. Main Outcomes and Measures: Prevalence of NVLD. Criteria for NVLD were based on clinical records of deficits in visual-spatial reasoning and impairment in 2 of 4 domains of function (fine-motor skills, math calculation, visual executive functioning, and social skills). Sample weighting procedures adjusted for demographic differences in sample frequencies compared with underlying target populations. Inflation factor weights accounted for overrepresentation of psychiatric disorders (HBN and NKI samples). Results: Across 3 independent samples, the prevalence of NVLD was estimated among 2596 children and adolescents aged 6 to 19 years (mean [SD] age, 12.5 [3.4] years; 1449 male [55.8%]). After sample and inflation weights were applied, the prevalence of NVLD was 2.78% (95% CI, 2.03%-3.52%) in the HBN sample and 3.9% (95% CI, 1.96%-5.78%) in the NKI sample. In the SYS sample, the prevalence of NVLD was 3.10% (95% CI, 1.93%-4.27%) after applying the sample weight. Across samples and estimation strategies, the population prevalence of NVLD was estimated to range from 3% to 4%. When applied to the US population younger than 18 years, 2.2 million to 2.9 million children and adolescents were estimated to have NVLD. Conclusions and Relevance: The findings suggest that the prevalence of NVLD in children and adolescents may be 3% to 4%. Given that few youths are diagnosed with NVLD and receive treatment, increased awareness, identification of the underlying neurobiological mechanisms, and development and testing interventions for the disorder are needed.

Indexed as

AdolescentCanadaChildCross-Sectional StudiesFemaleHumansLearning DisabilitiesMalePrevalenceUnited States

Identifiers

PMID32275324
PMCPMC7148441
OpenAlexW3016057118

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.