Evidence map›Paper›PMID 32274984›Full record

SynthesisThe American journal of tropical medicine and hygiene2020

Selection of Diagnostic Cutoffs for Murine Typhus IgM and IgG Immunofluorescence Assay: A Systematic Review.

Sandhya Dhawan, Matthew T Robinson, John Stenos, Stephen R Graves, Tri Wangrangsimakul, Paul N Newton, Nicholas P J Day, Stuart D Blacksell

Open access · hybridAbstract readSystematic Review
In one paragraph

Synthesis in The American journal of tropical medicine and hygiene, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Seroprevalence ofVeterinary world · 2023
    Article
  7. An Update on the Laboratory Diagnosis ofPathogens (Basel, Switzerland) · 2021
    Review
  8. Manifestations and Management of Flea-Borne Rickettsioses.Research and reports in tropical medicine · 2021
    Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 4 countries.

Sandhya Dhawan1Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Matthew T Robinson2Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
John Stenos4Australian Rickettsial Reference Laboratory, University Hospital Geelong, Geelong, Australia.
Stephen R Graves4Australian Rickettsial Reference Laboratory, University Hospital Geelong, Geelong, Australia.
Tri Wangrangsimakul1Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Paul N Newton2Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Nicholas P J Day1Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Stuart D Blacksell1Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Geelong Hospital · AUMahidol University · THLao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit · LAMahidol Oxford Tropical Medicine Research Unit · THUniversity of Oxford · GBWellcome Trust · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

Murine typhus is a neglected but widespread infectious disease that results in acute fever. The immunofluorescence assay (IFA) is the "gold standard" to identify IgM or IgG antibodies, although there is a lack of standardization in methodologies. The objective of this review is to summarize 1) the differences in published methodologies, 2) the diagnostic cutoff titers, and 3) the justification of diagnostic cutoffs. Searches were performed by combining the following search terms: "murine typhus," "

Indexed as

Antibodies, BacterialFluorescent Antibody TechniqueHumansImmunoglobulin GImmunoglobulin MNeglected DiseasesPredictive Value of TestsRickettsia typhiTyphus, Endemic Flea-BorneAntibodies, BacterialImmunoglobulin GImmunoglobulin M

Identifiers

PMID32274984
PMCPMC7356422
OpenAlexW3015864265

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.