Evidence map›Paper›PMID 32274803›Full record

ArticleEpilepsia2020

Early developmental electroencephalography abnormalities, neonatal seizures, and induced spasms in a mouse model of tuberous sclerosis complex.

Nicholas Rensing, Kevin J Johnson, Thomas J Foutz, Joseph L Friedman, Rafael Galindo, Michael Wong

Open access · greenAbstract read
In one paragraph

Article in Epilepsia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Infantile epileptic spasms syndrome: Mechanisms and therapeutic approaches.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Review
  2. NEAT1 Promotes Epileptogenesis in Tuberous Sclerosis Complex.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Critical periods and Autism Spectrum Disorders, a role for sleep.Neurobiology of sleep and circadian rhythms · 2023
    Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Nicholas RensingDepartment of Neurology and Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri.
Kevin J JohnsonDepartment of Neurology and Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri.
Thomas J FoutzDepartment of Neurology and Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri.
Joseph L FriedmanDepartment of Neurology and Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri.
Rafael GalindoDepartment of Neurology and Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri.
Michael WongDepartment of Neurology and Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri.ORCID 0000-0002-3796-743X
Hope Center for Neurological Disorders · US

Funding

Washington University Intellectual and Developmental Disabilities Research Center-Administrative Down Syndrome SupplementU54HD087011 · NICHD · WASHINGTON UNIVERSITY · PI CONSTANTINO, JOHN N. · 2015 to 2019
$7.1M
MECHANISMS OF BRAIN DYSFUNCTION IN TUBEROUS SCLEROSISR01NS056872 · NINDS · WASHINGTON UNIVERSITY · PI WONG, MICHAEL · 2006 to 2019
$4.0M
Neuroprotective Actions of hCG in a Mouse Model of Term and Preterm Brain InjuryR01NS112234 · NINDS · WASHINGTON UNIVERSITY · PI GALINDO, RAFAEL · 2019 to 2023
$1.7M
A MOUSE MODEL OF INFANTILE SPASMS IN TUBEROUS SCLEROSIS COMPLEXR21NS104522 · NINDS · WASHINGTON UNIVERSITY · PI WONG, MICHAEL · 2018 to 2019
$419k
WHOLE SLIDE IMAGING SYSTEM FOR TRANSLATIONAL NEUROSCIENCES10RR027552 · NCRR · WASHINGTON UNIVERSITY · PI LEE, JIN-MOO · 2010 to 2010
$275k
Hope Center for Neurological DisordersMissouri Department of Mental HealthNCRR NIH HHS S10 RR027552NICHD NIH HHS U54 HD087011NINDS NIH HHS R01 NS056872NINDS NIH HHS R01 NS112234NINDS NIH HHS R21 NS104522
6 · The paper itself

Abstract

objectiveTuberous sclerosis complex (TSC) is one of the most common genetic causes of epilepsy. Seizures in TSC typically first present in infancy or early childhood, including focal seizures and infantile spasms. Infantile spasms in TSC are particularly characteristic in its strong responsiveness to vigabatrin. Although a number of mouse models of epilepsy in TSC have been described, there are very limited electroencephalographic (EEG) or seizure data during the preweanling neonatal and infantile-equivalent mouse periods. Tsc1

methodsLongitudinal video-EEG and electromyographic recordings were performed serially on Tsc1

resultsThe interictal EEG of Tsc1 SIGNIFICANCE: Neonatal Tsc1

Indexed as

AnimalsAnimals, NewbornArousalDisease Models, AnimalElectroencephalographyElectromyographyFemaleMaleMiceMice, Inbred C57BLN-MethylaspartateSeizuresTuberous SclerosisN-MethylaspartateEEGelectroencephalographyepilepsyinfantile spasmsseizuretuberous sclerosis

Identifiers

PMID32274803
PMCPMC9417212
OpenAlexW3016132752

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.