Evidence map›Paper›PMID 32274662›Full record

ArticleAnnals of surgical oncology2020

Minimally Invasive Versus Open Liver Resection for Hepatocellular Carcinoma in the Setting of Portal Vein Hypertension: Results of an International Multi-institutional Analysis.

Andrea Ruzzenente, Fabio Bagante, Francesca Ratti, Laura Alaimo, Hugo P Marques, Silvia Silva, Olivier Soubrane, Itaru Endo, Kota Sahara, Eliza W Beal and 11 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Annals of surgical oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 11 institutions in 8 countries.

Andrea RuzzenenteDepartment of Surgery, University of Verona, Verona, Italy.
Fabio BaganteDepartment of Surgery, University of Verona, Verona, Italy.
Francesca RattiDepartment of Surgery, Ospedale San Raffaele, Milan, Italy.
Laura AlaimoDepartment of Surgery, University of Verona, Verona, Italy.
Hugo P MarquesDepartment of Surgery, Curry Cabral Hospital, Lisbon, Portugal.
Silvia SilvaDepartment of Surgery, Curry Cabral Hospital, Lisbon, Portugal.
Olivier SoubraneDepartment of Hepatobiliopancreatic Surgery, APHP, Beaujon Hospital, Clichy, France.
Itaru EndoDepartment of Gastroenterological Surgery, Yokohama City University, Yokohama, Japan.
Kota SaharaDepartment of Gastroenterological Surgery, Yokohama City University, Yokohama, Japan.
Eliza W BealDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Vincent LamDepartment of Surgery, Westmead Hospital, Sydney, NSW, Australia.
George A PoultsidesDepartment of Surgery, Stanford University, Stanford, CA, USA.
Eleftherios A MakrisDepartment of Surgery, Stanford University, Stanford, CA, USA.
Irinel PopescuDepartment of Surgery, Fundeni Clinical Institute, Bucharest, Romania.
Sorin AlexandrescuDepartment of Surgery, Fundeni Clinical Institute, Bucharest, Romania.
Guillaume MartelDepartment of Surgery, University of Ottawa, Ottawa, ON, Canada.
Aklile WorknehDepartment of Surgery, University of Ottawa, Ottawa, ON, Canada.
Thomas J HughDepartment of Surgery, University of Sydney, Royal North Shore Hospital, Sydney, NSW, Australia.
Alfredo GuglielmiDepartment of Surgery, University of Verona, Verona, Italy.
Luca AldrighettiDepartment of Surgery, Ospedale San Raffaele, Milan, Italy.
Timothy M PawlikDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA. tim.pawlik@osumc.edu.
University of Verona · ITHospital Curry Cabral · PTInstitutul Clinic Fundeni · ROIRCCS Ospedale San Raffaele · ITStanford University · USThe Ohio State University Wexner Medical Center · USUniversity of Ottawa · CAYokohama City University · JPHôpital Beaujon · FRRoyal North Shore Hospital · AUWestmead Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with hepatocellular carcinoma (HCC) and portal vein hypertension assessed with platelet count (PVH-PLT; platelet count < 100,000/mL) are often denied surgery even when the disease is technically resectable. Short- and long-term outcomes of patients undergoing minimally invasive surgery (MIS) versus open resection for HCC and PVH-PLT were compared.

methodsPropensity score matching (PSM) was used to balance the clinicopathological differences between MIS and non-MIS patents. Univariate comparison and standard survival analyses were utilized.

resultsAmong 1974 patients who underwent surgery for HCC, 13% had a PVH-PLT and 33% underwent MIS. After 1:1 PSM, 407 MIS and 407 non-MIS patients were analyzed. Incidence of complications and length-of-stay (LoS) were higher among non-MIS versus MIS patients (both p ≤ 0.002). After PSM, among 178 PVH-PLT patients (89 MIS and 89 non-MIS), patients who underwent a non-MIS approach had longer LoS (> 7 days; non-MIS: 55% vs. MIS: 29%), as well as higher morbidity (non-MIS: 42% vs. MIS: 29%) [p <0.001]. In contrast, long-term oncological outcomes were comparable, including 3-year overall survival (non-MIS: 66.2% vs. MIS: 72.9%) and disease-free survival (non-MIS: 47.3% vs. MIS: 50.2%) [both p ≥ 0.08].

conclusionAn MIS approach was associated with improved short-term outcomes, but similar long-term outcomes, compared with open liver resection for patients with HCC and PVH-PLT. An MIS approach for liver resection should be considered for patients with HCC, even those individuals with PVH-PLT.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsAgedFemaleHepatectomyHumansHypertension, PortalMaleMiddle AgedMinimally Invasive Surgical ProceduresPlatelet CountPortal PressurePortal VeinRetrospective StudiesThrombocytopeniaTreatment Outcome

Identifiers

PMID32274662
OpenAlexW3015669546

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.