Evidence map›Paper›PMID 32274628›Full record

ArticleNeurochemical research2020

TRPC6-Mediated Ca

Zhaowei Liu, Zhanqiang Du, Kai Li, Yangguang Han, Guogang Ren, Zhuo Yang

Abstract read
PubMed Publisher
In one paragraph

Article in Neurochemical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Therapeutic effects of SKF-96365 on murine allergic rhinitis induced by OVA.International journal of immunopathology and pharmacology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Zhaowei LiuCollege of Medicine, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials Ministry of Education, Nankai University, No.94, Weijin Road, Nankai District, Tianjin, 300071, China. zhaoweiliu@nankai.edu.cn.
Zhanqiang DuCollege of Medicine, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials Ministry of Education, Nankai University, No.94, Weijin Road, Nankai District, Tianjin, 300071, China.
Kai LiCollege of Medicine, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials Ministry of Education, Nankai University, No.94, Weijin Road, Nankai District, Tianjin, 300071, China.
Yangguang HanSchool of precision instrument and optoelectronic engineering, Tianjin University, Tianjin, 300072, China.
Guogang RenScience and Technology Research Institute, University of Hertfordshire, Hatfield, Herts, AL10 9AB, UK.
Zhuo YangCollege of Medicine, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials Ministry of Education, Nankai University, No.94, Weijin Road, Nankai District, Tianjin, 300071, China. zhuoyang@nankai.edu.cn.ORCID http://orcid.org/0000-0001-5212-0053
Nankai University · CNTianjin University · CNUniversity of Hertfordshire · GB

Funding

The National Natural Science Foundation of China 81571804The National Natural Science Foundation of China 81771979
6 · The paper itself

Abstract

Recently, possible applications of zinc oxide nanoparticles (nano-ZnO) have been extensively studied owing to their ease of synthesis. However, the effect of nano-ZnO on the nervous system remains unclear. This study investigates the action of nano-ZnO on SH-SY5Y neuroblastoma cells. We found that nano-ZnO (0-50 µg/mL) induced a significant decrease in cell survival rate in a dose-dependent manner, and increased LC3 puncta formation. However, the apoptosis was not affected by nano-ZnO, because the protein levels of cytochrome c, caspase-3, Bcl-xL, and BAX were not varied by the nano-ZnO treatment. Nano-ZnO increased Ca

Indexed as

AutophagyCalcium SignalingCell Line, TumorDose-Response Relationship, DrugHumansNanoparticlesTRPC6 Cation ChannelZinc OxideTRPC6 Cation ChannelTRPC6 protein, humanZinc OxideAutophagyCa2+CurrentNano-ZnOTRPC6

Identifiers

PMID32274628
OpenAlexW3016265067

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.