Evidence map›Paper›PMID 32274578›Full record

ArticleJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2020

Molecular mechanisms of apoptosis induction in K562 and KG1a leukemia cells by a water-soluble copper(II) thiosemicarbazone complex.

Fatemeh Ghorbani Parsa, Mohammad Ali Hosseinpour Feizi, Reza Safaralizadeh, Seyed Abolfazl Hosseini-Yazdi, Majid Mahdavi

Abstract read
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In one paragraph

Article in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Involvement of copper in cell death and cancer.Apoptosis : an international journal on programmed cell death · 2025
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Fatemeh Ghorbani ParsaDepartment of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
Mohammad Ali Hosseinpour FeiziDepartment of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran. pourfeizi@eastp.ir.
Reza SafaralizadehDepartment of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
Seyed Abolfazl Hosseini-YazdiDepartment of Inorganic Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz, Iran.
Majid MahdaviDepartment of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran. majid.mahdavi@tabrizu.ac.ir.
University of Tabriz · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thiosemicarbazones (TSCs) and their metal complexes exhibit pronounced and selective cytotoxic potential against a broad span of cancers. Here, we assessed the anti-cancer activity of a water-soluble copper(II) complex of thiosemicarbazone (Cu-TSC) against two cancer cell lines of human leukemia. Our analysis revealed that Cu-TSC treatment results in a time and dose-dependent growth inhibition in K562 and KG1a cells while sparing normal human fibroblast (HFF2) cells. The IC

Indexed as

Antineoplastic AgentsApoptosisCell CycleCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMolecular StructureOrganometallic CompoundsReactive Oxygen SpeciesSolubilityThiosemicarbazonesTumor Cells, CulturedWaterAntineoplastic Agentscopper-thiosemicarbazone complexOrganometallic CompoundsReactive Oxygen SpeciesThiosemicarbazonesWaterApoptosisCaspaseCopperLeukemiaReactive oxygen speciesThiosemicarbazone

Identifiers

PMID32274578
OpenAlexW3015417128

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.