Evidence map›Paper›PMID 32274500›Full record

Trial reportSleep2020

A novel approach to management of sleep-associated problems in patients with breast cancer (MOSAIC) during chemotherapy : A pilot study.

Oxana Palesh, Natalie Solomon, Elisa Hofmeister, Booil Jo, Hanyang Shen, Erin Cassidy-Eagle, Pasquale F Innominato, Karen Mustian, Shelli Kesler

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Sleep, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 6 pooled it
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 6 syntheses or guidelines pooled it, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Oxana PaleshDepartment of Psychiatry and Behavioral Sciences, Stanford School of Medicine, Stanford University, Stanford, CA.
Natalie SolomonPGSP Stanford Psy.D. Consortium, Palo Alto University, Palo Alto, CA.
Elisa HofmeisterDepartment of Psychiatry and Behavioral Sciences, Stanford School of Medicine, Stanford University, Stanford, CA.
Booil JoDepartment of Psychiatry and Behavioral Sciences, Stanford School of Medicine, Stanford University, Stanford, CA.
Hanyang ShenDepartment of Psychiatry and Behavioral Sciences, Stanford School of Medicine, Stanford University, Stanford, CA.
Erin Cassidy-EagleDepartment of Psychiatry and Behavioral Sciences, Stanford School of Medicine, Stanford University, Stanford, CA.
Pasquale F InnominatoNorth Wales Cancer Centre, Ysbyty Gwynedd, Betsi Cadwaladr University Health Board, Bangor, UK.
Karen MustianDepartment of Surgery, University of Rochester, Rochester, NY.
Shelli KeslerCancer Neuroscience Laboratory, School of Nursing, University of Texas at Austin, Austin, TX.
Stanford University · USInserm · FRPalo Alto University · USThe University of Texas at Austin · USUniversity of Rochester · US

Funding

Multicenter Randomized Controlled Trial of Brief Behavioral Therapy for Cancer Related InsomniaR01CA239714 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI PALESH, OXANA G · 2020 to 2025
$4.5M
Very-long Term Neurocognitive Outcomes in Breast Cancer Survivors (ProbC2)R01CA172145 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI KESLER, SHELLI R, PALESH, OXANA G · 2012 to 2024
$3.3M
Brief Behavioral Intervention for Insomnia During ChemotherapyR01CA181659 · NCI · STANFORD UNIVERSITY · PI PALESH, OXANA G · 2014 to 2018
$3.1M
NCI NIH HHS R01 CA172145NCI NIH HHS R01 CA181659NCI NIH HHS R01 CA239714
6 · The paper itself

Abstract

STUDY

objectivesThis pilot randomized controlled trial (RCT) was conducted to assess the preliminary effects of Brief Behavioral Therapy for Cancer-Related Insomnia (BBT-CI) delivered by trained research staff in comparison to a sleep hygiene pamphlet control and to assess moderators of treatment effect in patients with breast cancer undergoing chemotherapy.

methodsOf 74 participants recruited, 37 were randomized to BBT-CI and 37 were randomized to the control condition. Trained staff members delivered the intervention during chemotherapy treatments to reduce patients' burden. Insomnia was assessed with the Insomnia Severity Index (ISI), anxiety was assessed with the Spielberger State-Trait Anxiety Inventory, symptom burden was assessed with the Symptom Inventory (SI), and study staff recorded previous treatments and surgeries received by patients.

resultsPatients randomized to BBT-CI showed significantly greater improvements in their ISI scores compared to the sleep hygiene group. Additionally, several treatment moderators were identified. The effect of BBT-CI was greater among individuals with lower baseline state-trait anxiety, with previous surgery for cancer, and with higher baseline somatic symptom severity.

conclusionsBBT-CI shows preliminary efficacy compared to the sleep hygiene handout on insomnia in cancer patients undergoing chemotherapy. A large-phase III RCT needs to be conducted to replicate the preliminary findings.

Indexed as

Breast NeoplasmsCognitive Behavioral TherapySleep Initiation and Maintenance DisordersHumansPilot ProjectsSleepTreatment Outcomebehavioral interventionbreast cancercancerCBT-Iinsomniasleep

Identifiers

PMID32274500
PMCPMC7755138
OpenAlexW3015848972

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.