Evidence map›Paper›PMID 32274454›Full record

ArticleKidney international reports2020

Long-Term Peridialytic Blood Pressure Patterns in Patients Treated by Hemodialysis and Hemodiafiltration.

Paul A Rootjes, Camiel L M de Roij van Zuijdewijn, Muriel P C Grooteman, Michiel L Bots, Bernard Canaud, Peter J Blankestijn, Frans J van Ittersum, Francisco Maduell, Marion Morena, Sanne A E Peters and 4 more

Open access · goldAbstract read
In one paragraph

Article in Kidney international reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Article
  4. Long-term peridialytic blood pressure changes are related to mortality.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 5 countries.

Paul A RootjesDepartment of Nephrology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, VU University, Amsterdam, the Netherlands.
Camiel L M de Roij van ZuijdewijnDepartment of Nephrology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, VU University, Amsterdam, the Netherlands.
Muriel P C GrootemanDepartment of Nephrology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, VU University, Amsterdam, the Netherlands.
Michiel L BotsJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Bernard CanaudCenter of Excellence Medical, Fresenius Medical Care GmbH, Bad Homburg, Germany.
Peter J BlankestijnDepartment of Nephrology & Hypertension, University Medical Center Utrecht, Utrecht, the Netherlands.
Frans J van IttersumDepartment of Nephrology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, VU University, Amsterdam, the Netherlands.
Francisco MaduellDepartment of Nephrology, Hospital Clinic, Barcelona, Spain.
Marion MorenaPhyMedExp, National Institute of Health and Medical Research, French National Centre for Scientific Research, University of Montpellier, Department of Biochemistry and Endocrinology, Central University Hospital Montpellier, Montpellier, France.
Sanne A E PetersThe George Institute for Global Health, University of Oxford, Oxford, UK.
Andrew DavenportRoyal Free Hospital, University College London Medical School, London, UK.
Robin W M VernooijJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Menso J NubéDepartment of Nephrology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, VU University, Amsterdam, the Netherlands.
HDF Pooling Project Investigators
Amsterdam University Medical Centers · NLUniversité de Montpellier · FRUtrecht University · NLHospital Clínic de Barcelona · ESInserm · FRThe George Institute for Global Health · GBThe Royal Free Hospital · GBUniversity Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionOnline postdilution hemodiafiltration (HDF) is associated with a lower all-cause and cardiovascular mortality than hemodialysis (HD). This may depend on a superior peridialytic (pre- and postdialysis, and the difference between these 2 parameters) hemodynamic profile.

methodsIn this retrospective cohort analysis of individual participant data (IPD) from 3 randomized controlled trials (RCTs) (

resultsMean pre- and postdialysis SBP, DBP, and MAP declined significantly during follow-up (predialytic: SBP -2.16 mm Hg, DBP -2.88 mm Hg, MAP -2.64 mm Hg), PP increased (predialytic 0.96 mm Hg). Peridialytic deltas remained unaltered. Differences between the 2 modalities, or between quartiles of convection volume were not observed. BP changes were independent of various baseline characteristics, including the decline in body weight over time.

conclusionWe speculate that the combination of a decreasing SBP and an increasing PP may be the clinical sequelae of a worsening cardiovascular system. Because especially HDF with a high convection volume has been associated with a beneficial effect on survival, our study does not support the view that superior peridialytic BP control contributes to this effect.

Indexed as

blood pressurehemodiafiltrationhemodialysisindividual participant dataperidialytic

Identifiers

PMID32274454
PMCPMC7136332
OpenAlexW3004279425

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.