ArticleJournal of thoracic disease2020
Delayed surgery after histologic or radiologic-diagnosed clinical stage I lung adenocarcinoma.
Article in Journal of thoracic disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Association between time-to-treatment and outcomes in non-small cell lung cancer: a systematic review.Thorax · 2022Pooled it
- Redefining treatment interval in lung cancer surgery in the era of prehabilitation: a systematic review.Translational lung cancer research · 2025Review
- Wait times between lung cancer diagnosis and surgery: national trends, disparities, and impact on long-term survival.Journal of thoracic disease · 2025Article
- Critical timing: Impact of delays to surgery on prognosis in stage I-II non-small cell lung cancer.PloS one · 2025Article
- Article
- Short-Term Outcomes of COVID-19 Pandemic on Non-Small Cell Lung Cancer Screening and Management.Surgery journal (New York, N.Y.) · 2023Article
- Cancer treatment delays among cancer patients living with HIV during the COVID-19 pandemic in the United States.Cancer medicine · 2023Article
- Delays in Follow-up after a Positive Lung Cancer Screening Exam: Is the Benefit of Screening Compromised?Annals of the American Thoracic Society · 2023Article
- Timely Curative Treatment and Overall Mortality Among Veterans With Stage I NSCLC.JTO clinical and research reports · 2023Article
- The Impact of COVID-19 Pandemic on Surgical Treatment of Resectable Non-Small Cell Lung Cancer in Greece.Life (Basel, Switzerland) · 2023Article
- Analysis of Delayed Surgical Treatment and Oncologic Outcomes in Clinical Stage I Non-Small Cell Lung Cancer.JAMA network open · 2021Article
- Significance of preoperative biopsy in radiological solid-dominant clinical stage I non-small-cell lung cancer.Interactive cardiovascular and thoracic surgery · 2021Article
- Implications of Preoperative Transbronchial Lung Biopsy for Non-small Cell Lung Cancer Less than 3-cm.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe impact of delayed surgery on clinical outcomes after histologic or radiologic diagnosis of clinical stage I adenocarcinoma remains controversial. We evaluated the effects of delayed surgery on outcomes of patients with early-stage lung cancer.
methodsAssociations between time intervals of "histologic diagnosis-to-surgery" (HDS), "radiologic diagnosis-to-surgery" (RDS), and overall survival in clinical stage I adenocarcinoma were assessed using multivariable Cox proportional hazard analysis.
resultsA total of 561 consecutive patients with preoperative histologic confirmation of stage I lung cancer between 2006 and 2016 were included. Median time to HDS and RDS were 20 (2-267) and 58 (38-2,983) days. Higher Charlson comorbidity score, receiving brain magnetic resonance imaging screening, and video-assisted thoracoscopic surgery approach were significantly associated with increased risk of late HDS (>21 days). Smaller tumor size and non-radiologic solid-dominant pattern were significantly associated with increased risk of late RDS (>60 days). In the overall cohort, worse 5-year overall survival was associated with late HDS compared to early HDS (75.9%
conclusionsIn patients with stage I lung adenocarcinoma, delayed surgery after a histologic diagnosis is an independent predictor of overall survival after adjusting for clinical risk factors, suggesting meaningful differences in clinical outcomes between timely
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