ArticleJournal of thoracic disease2020
Prevalence and risk factors of reflux after esophagectomy for esophageal cancer.
Article in Journal of thoracic disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- A systematic review and meta-analysis of the prevalence of reflux symptoms after esophagectomy: patient-reported outcomes and management.BMC geriatrics · 2026Pooled it
- Clinical predictors of early reflux and symptom severity after esophagectomy: a risk prediction tool.Esophagus : official journal of the Japan Esophageal Society · 2026Article
- Identification of symptom clusters and associated factors based on disease characteristics in patients with esophageal cancer undergoing radiotherapy or chemoradiotherapy.Frontiers in medicine · 2026Article
- Development and validation of an early warning model for postoperative reflux in patients with esophageal cancer.Asia-Pacific journal of oncology nursing · 2025Article
- Symptoms experience during the oral intake rehabilitation period following esophagectomy: A network analysis.Asia-Pacific journal of oncology nursing · 2025Article
- LAsting Symptoms after Oesophageal Resectional Surgery (LASORS): multicentre validation cohort study.The British journal of surgery · 2025Article
- Analysis of the Trends and Influencing Factors for Postoperative Cough in Patients with Esophageal Cancer Based on Patient-Reported Outcomes.Annals of surgical oncology · 2024Article
- A case of Barrett's esophageal adenocarcinoma and severe scoliosis with successful salvage esophagectomy after definitive chemoradiotherapy.Surgical case reports · 2023Article
- Gastro-Intestinal Disorders and Micronutrient Deficiencies following Oncologic Esophagectomy and Gastrectomy.Cancers · 2023Review
- Efficacy and Postoperative Outcomes of Laparoscopic Retrosternal Route Creation for the Gastric Conduit: Propensity Score-Matched Comparison to Posterior Mediastinal Reconstruction.Annals of surgical oncology · 2023Article
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Authors and funding
5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundReflux symptoms including various extra-esophageal manifestations are commonly reported after esophagectomy. However, the intensity and presentation of reflux are both diverse and variable by patients. In this study we assessed reflux symptoms using the reflux symptom index (RSI) questionnaire in patients who underwent esophagectomy for esophageal cancer to order to identify the prevalence of significant reflux and its risk factors.
methodsFrom April 2017 to July 2017, we investigated patients who underwent esophagectomy for esophageal cancer. The severity of reflux was evaluated with a self-administered nine-item outcomes instrument (score: 0 to 5). An RSI score ≥13 was considered significant reflux. Multivariable analysis was conducted to identify risk factors.
resultsA total of 151 patients was included (mean age, 64.1±8.8 years; male, n=136, 90.1%). The median time after esophagectomy was 22.6 months. The question regarding heartburn, chest pain, indigestion, or acid coming up was most frequently responded (n=104, 68.9%) with 41 (27.2%) patients presenting significant reflux (mean RSI score, 19.9±6.3). Time after esophagectomy <2 years, vocal cord palsy, retrosternal route of reconstruction, and postoperative weight loss were identified as significant risk factors for RSI ≥13 in the multi-variable analysis.
conclusionsReflux related symptoms including extra-esophageal manifestations were common. Our study revealed that short duration after esophagectomy, vocal cord palsy, retrosternal route of reconstruction, and postoperative weight loss were significant associated factors for reflux symptom after esophagectomy.
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