Evidence map›Paper›PMID 32273944›Full record

ArticleOxidative medicine and cellular longevity2020

Redox-Active Drug, MnTE-2-PyP

Andrezza M Barbosa, José F Sarmento-Neto, José E R Menezes Filho, Itamar C G Jesus, Diego S Souza, Valério M N Vasconcelos, Fagner D L Gomes, Aline Lara, Juliana S S Araújo, Sandra S Mattos and 7 more

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Mn(III) Porphyrin MnTE-2-PyPACS infectious diseases · 2025
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. MnTE-2-PyP Suppresses Prostate Cancer Cell Growth via HAntioxidants (Basel, Switzerland) · 2020
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 2 countries.

Andrezza M BarbosaDepartment of Biotechnology, Federal University of Paraiba, Joao Pessoa, Brazil.
José F Sarmento-NetoDepartment of Chemistry, Federal University of Paraiba, Joao Pessoa, Brazil.ORCID https://orcid.org/0000-0002-2330-5494
José E R Menezes FilhoDepartment of Physiology, Federal University of Sergipe, Aracaju, Brazil.
Itamar C G JesusDepartment of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Diego S SouzaDepartment of Physiology, Federal University of Sergipe, Aracaju, Brazil.
Valério M N VasconcelosDepartment of Biotechnology, Federal University of Paraiba, Joao Pessoa, Brazil.
Fagner D L GomesDepartment of Biotechnology, Federal University of Paraiba, Joao Pessoa, Brazil.
Aline LaraDepartment of Biotechnology, Federal University of Paraiba, Joao Pessoa, Brazil.
Juliana S S AraújoHeart Circle, Recife, Brazil.
Sandra S MattosHeart Circle, Recife, Brazil.
Carla M L VasconcelosDepartment of Physiology, Federal University of Sergipe, Aracaju, Brazil.ORCID https://orcid.org/0000-0002-7197-0261
Silvia GuatimosimDepartment of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Jader S CruzDepartment of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Ines Batinic-HaberleDepartment of Radiation Oncology, Duke University School of Medicine, Durham, NC 27710, USA.
Demetrius A M AraújoDepartment of Biotechnology, Federal University of Paraiba, Joao Pessoa, Brazil.ORCID https://orcid.org/0000-0001-7320-7203
Júlio S RebouçasDepartment of Chemistry, Federal University of Paraiba, Joao Pessoa, Brazil.ORCID https://orcid.org/0000-0003-3818-029X
Enéas R GomesDepartment of Biotechnology, Federal University of Paraiba, Joao Pessoa, Brazil.ORCID https://orcid.org/0000-0001-8528-8741
Universidade Federal da Paraíba · BRUniversidade Federal de Minas Gerais · BRUniversidade Federal de Sergipe · BRCentro de Estudos e Sistemas Avançados do Recife · BRDuke University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCardiomyopathies remain among the leading causes of death worldwide, despite all efforts and important advances in the development of cardiovascular therapeutics, demonstrating the need for new solutions. Herein, we describe the effects of the redox-active therapeutic Mn(III)

methodsWistar rats weighing 250-300 g were used in both

resultsUsing isolated rat cardiomyocytes, we observed that MnTE-2-PyP

conclusionMnTE-2-PyP

Indexed as

AnimalsArrhythmias, CardiacCardiovascular SystemMaleMetalloporphyrinsOxidation-ReductionRatsRats, Wistarmanganese tetrakis-(N-ethyl-2 pyridyl) porphyrinMetalloporphyrins

Identifiers

PMID32273944
PMCPMC7115175
OpenAlexW3011135240

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.