ReviewFrontiers in neuroscience2020
Walking the Tightrope: A Proposed Model of Chronic Pain and Stress.
Review in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Autonomic indices of negative emotion regulation predict treatment response in opioid-treated chronic low back pain.The journal of pain · 2026Trial
- Trial
- Parental upheaval experienced in childhood and its effect on pain-related cognitions across the lifespan: an exploratory investigation.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- Developing and validating prediction models for low back pain and neck pain in office workers: a cross-sectional study.Scientific reports · 2025Article
- Using fast periodic visual stimulation to investigate the processing of health-related images in the human brain.Scientific reports · 2025Article
- Somatosensory and prefrontal cortex activity relates to emotional outcomes and hair cortisol concentration in chronic postsurgical pain.Scientific reports · 2025Article
- At the Intersection of Pain and Sleep: a Roadmap for Preclinical Pain Research.Frontiers in pain research (Lausanne, Switzerland) · 2025Review
- Prevalence, correlates, and quality-of-life outcomes of major or persistent pain among women living with HIV in Metro Vancouver, Canada.Harm reduction journal · 2024Article
- Relational vulnerability in motherhood-an existential perspective on pain and exhaustion among women.Frontiers in psychology · 2024Article
- Forced swim stress exacerbates inflammation-induced hyperalgesia and oxidative stress in the rat trigeminal ganglia.Frontiers in pain research (Lausanne, Switzerland) · 2024Article
- Investigating the Impact of Stress on Pain: A Scoping Review on Sense of Control, Social-Evaluative Threat, Unpredictability, and Novelty (STUN Model).Journal of pain research · 2024Article
- Elucidating individual differences in chronic pain and whole person health with allostatic load biomarkers.Brain, behavior, & immunity - health · 2023Article
- The Biology of Chronic Pain and Its Implications for Pain Neuroscience Education: State of the Art.Journal of clinical medicine · 2023Review
- Psychosocial risk factors for low back pain in US workers: Data from the 2002-2018 quality of work life survey.American journal of industrial medicine · 2023Article
- Neural correlates linking trauma and physical symptoms.Psychiatry research. Neuroimaging · 2022Article
- Kundalini Yoga for Post-Treatment Lyme Disease: A Preliminary Randomized Study.Healthcare (Basel, Switzerland) · 2022Article
- Pain catastrophizing, pain sensitivity and fear of pain are associated with early life environmental unpredictability: a path model approach.BMC psychology · 2022Article
- The neurobiology of pain and facial movements in rodents: Clinical applications and current research.Frontiers in veterinary science · 2022Review
- Chronic Stress and Gonadectomy Affect the Expression of Cx37, Cx40 and Cx43 in the Spinal Cord.Life (Basel, Switzerland) · 2021Article
- Investigating key predictors of persistent low back pain: A focus on psychological stress.Applied nursing research : ANR · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Pain and stress are both phenomena that challenge an individual's homeostasis and have significant overlap in conceptual and physiological processes. Allostasis is the ability to adapt to pain and stress and maintain homeostasis; however, if either process becomes chronic, it may result in negative long-term outcomes. The negative effects of stress on health outcomes on physiology and behavior, including pain, have been well documented; however, the specific mechanisms of how stress and what quantity of stress contributes to the maintenance and exacerbation of pain have not been identified, and thus pharmacological interventions are lacking. The objective of this brief review is to: 1. identify the gaps in the literature on the impact of acute and chronic stress on chronic pain, 2. highlight future directions for stress and chronic pain research; and 3. introduce the Pain-Stress Model in the context of the current literature on stress and chronic pain. A better understanding of the connection between stress and chronic pain could provide greater insight into the neurobiology of these processes and contribute to individualized treatment for pain rehabilitation and drug development for these often comorbid conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.