ArticleFrontiers in neuroscience2020
Twice-Daily Theta Burst Stimulation of the Dorsolateral Prefrontal Cortex Reduces Methamphetamine Craving: A Pilot Study.
Article in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Theta Burst Transcranial Magnetic Stimulation for the Treatment of Methamphetamine Use Disorder
TMS (Transcranial Magnetic Stimulation) for Methamphetamine Use Disorder in People Living With HIV
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Objective and subjective measurement of sleep in people who use substances: Emerging evidence and recommendations from a systematic review.Journal of sleep research · 2025Pooled it
- A Systematic Review of the Safety and Tolerability of Theta Burst Stimulation in Children and Adolescents.Neuromodulation : journal of the International Neuromodulation Society · 2022Pooled it
- Precision non-invasive transcranial electromagnetic stimulation: a thematic review of optimizing spatial, temporal, and dose dimensions.European archives of psychiatry and clinical neuroscience · 2026Review
- Combined accelerated theta burst stimulation and reading instruction for the treatment of persistent developmental dyslexia: methodology and preliminary findings.Frontiers in human neuroscience · 2026Article
- Non-invasive neurostimulation techniques for the treatment of stimulant use disorders.Frontiers in psychiatry · 2026Review
- Repetitive transcranial magnetic stimulation for substance use disorders and chronic pain: A review of the evidence and call for increased mechanistic understanding.Current addiction reports · 2025Article
- Sex-specific effects of predator scent stress on fear, anxiety-like behavior and methamphetamine seeking in rats.Addiction neuroscience · 2025Article
- Repetitive transcranial magnetic stimulation for stimulant use disorders (STIMULUS): protocol for a multi-site, double-blind, randomized controlled trial.Addiction science & clinical practice · 2025Article
- Potential use of repetitive transcranial magnetic stimulation in treating pediatric avoidant/restrictive food intake disorder: a case report.Frontiers in psychology · 2025Article
- Noninvasive Therapies: A Forthcoming Approach to Parkinson's Treatment.CNS & neurological disorders drug targets · 2025Review
- Neuromodulatory transcranial magnetic stimulation (TMS) changes functional connectivity proportional to the electric-field induced by the TMS pulse.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Article
- Transcranial magnetic stimulation for methamphetamine use disorder: A scoping review within the neurocircuitry model of addiction.Psychiatry research · 2024Article
- Accelerated Theta Burst Stimulation: Safety, Efficacy, and Future Advancements.Biological psychiatry · 2024Review
- Review
- Transcranial Stimulation for the Treatment of Stimulant Use Disorder.Neurology international · 2023Review
- Combining noninvasive brain stimulation with behavioral pharmacology methods to study mechanisms of substance use disorder.Frontiers in neuroscience · 2023Article
- Challenges and future trends in wearable closed-loop neuromodulation to efficiently treat methamphetamine addiction.Frontiers in psychiatry · 2023Review
- A transdiagnostic review of safety, efficacy, and parameter space in accelerated transcranial magnetic stimulation.Journal of psychiatric research · 2022Review
- The roles of the LpSTS and DLPFC in self-prioritization: A transcranial magnetic stimulation study.Human brain mapping · 2022Article
- Intermittent Theta Burst Stimulation vs. High-Frequency Repetitive Transcranial Magnetic Stimulation in the Treatment of Methamphetamine Patients.Frontiers in psychiatry · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 5 institutions in 2 countries.
Funding
Abstract
objectivesTranscranial magnetic stimulation (TMS) holds potential promise as a therapeutic modality for disorders of addiction. Our previous findings indicate that high-frequency repetitive transcranial magnetic stimulation (rTMS) over the left dorsal-lateral prefrontal cortex (DLPFC) and low-frequency rTMS over the right DLPFC can reduce drug craving for methamphetamine. One major issue with rTMS is the duration of treatment and hence potential dropout rate. Theta burst stimulation (TBS) has been recently shown to be non-inferior relative to repetitive transcranial magnetic stimulation for major depression. Here, we aim to compare the clinical efficacy and tolerability of intermittent and continuous theta burst stimulation protocols targeting left or right dorsolateral prefrontal cortex on methamphetamine craving in abstinent-dependent subjects.
methodsIn this randomized single-blind pilot study, 83 abstinent methamphetamine-dependent subjects from a long-term residential treatment program were randomly allocated into three groups: intermittent theta burst stimulation (iTBS) over the left DLPFC (active group), continuous theta burst stimulation (cTBS) over the left DLPFC (active control group), or cTBS over the right DLPFC (active group) was administered twice daily over 5 days for a total of 10 sessions. We measured the primary outcome of cue-induced craving and secondarily sleep quality, depression, anxiety, impulsivity scores, and adverse effects.
resultsWe show a pre- vs. postintervention effect on craving, which, on paired
conclusionAccelerated twice-daily TBS appears feasible and tolerable at modulating craving and mood changes in abstinent methamphetamine dependence critically while reducing session length. We emphasize the need for a larger randomized controlled trial study with a sham control to confirm these findings and longer duration of clinically relevant follow-up. CLINICAL
trial registrationChinese Clinical Trial Registry number, 17013610.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.