ArticleReproductive medicine and biology2020
Physiological role of actin regulation in male fertility: Insight into actin capping proteins in spermatogenic cells.
Article in Reproductive medicine and biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- Alterations of actin in aging.Journal of cell science · 2026Review
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- Sperm DNA methylation landscape and its links to male fertility in a non-model teleost using EM-seq.Heredity · 2025Article
- Article
- Article
- Unveiling Gene Expression Dynamics during Early Embryogenesis inLife (Basel, Switzerland) · 2024Article
- The Slingshot phosphatase 2 is required for acrosome biogenesis during spermatogenesis in mice.eLife · 2023Article
- Investigation of Sperm and Seminal Plasma Candidate MicroRNAs of Bulls with Differing Fertility and In Silico Prediction of miRNA-mRNA Interaction Network of Reproductive Function.Animals : an open access journal from MDPI · 2022Article
- Pervasiveness of intronless genes expressed in haploid germ cell differentiation.Reproductive medicine and biology · 2021Review
- Article
- Physiological role of actin regulation in male fertility: Insight into actin capping proteins in spermatogenic cells.Reproductive medicine and biology · 2020Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDuring spermatogenesis, cytoskeletal elements are essential for spermatogenic cells to change morphologically and translocate in the seminiferous tubule. Actin filaments have been revealed to be concentrated in specific regions of spermatogenic cells and are regulated by a large number of actin-binding proteins. Actin capping protein is one of the essential actin regulatory proteins, and a recent study showed that testis-specific actin capping protein may affect male infertility.
methodsThe roles of actin during spermatogenesis and testis-specific actin capping protein were reviewed by referring to the previous literature. MAIN FINDINGS
resultsActin filaments are involved in several crucial phases of spermatogenesis including acrosome biogenesis, flagellum formation, and nuclear processes such as the formation of synaptonemal complex. Besides, an implication for capacitation and acrosome reaction was also suggested. Testis-specific actin capping proteins are suggested to be associated with the removal of excess cytoplasm in mice. By the use of high-throughput sperm proteomics, lower protein expression of testis-specific actin capping protein in infertile men was also reported.
conclusionActin is involved in the crucial phases of spermatogenesis, and the altered expression of testis-specific actin capping proteins is suggested to be a cause of male infertility in humans.
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