ArticleTherapeutics and clinical risk management2020
Efficacy and Safety of Epilepsy Surgery for Older Adult Patients with Refractory Epilepsy.
Article in Therapeutics and clinical risk management, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 9 citations in OpenAlex.
- Cost-effectiveness of laser interstitial thermal therapy vs. anterior temporal lobectomy for drug-resistant mesial temporal lobe epilepsy: A decision analytic model.Epilepsia open · 2026Article
- Why patients say no: Patient barriers to epilepsy surgery among patients with drug-resistant epilepsy in Singapore.Epilepsia open · 2025Article
- Single center outcomes of intracranial evaluation and surgical intervention in the elderly population.Epilepsy & behavior reports · 2022Article
- Large-scale resculpting of cortical circuits in children after surgical resection.Scientific reports · 2020Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe population of elderly patients with epilepsy has been growing rapidly and the chances of referring older patients with refractory epilepsy for surgical options could be increasing. In general, epilepsy surgery at higher ages has been less likely to be performed, because little is known regarding the risks and benefits in elderly patients. We, therefore, investigated surgical outcomes and comorbidities in a population ≥50 years old who underwent epilepsy surgery.
methodsPatients ≥50 years old who underwent epilepsy surgery were identified from the database of our epilepsy center for the period from 2009 to 2017. Surgical complications and seizure outcome were reviewed, and seizure outcomes were evaluated using the International League Against Epilepsy (ILAE) surgery outcome scale.
resultsThe mean age of 32 patients at the time of surgery was 56.1±5.1 years. The mean duration of epilepsy was 23.4±18.5 years and mean follow-up was 2.7±2.0 years. As of the most recent visit, 56.3% of patients remained completely seizure-free (ILAE Class I). The surgery-related complication rate was 11.5%, comprising permanent deficits in 3.8% and transient deficits in 7.7%.
conclusionThese results suggest that epilepsy surgery may represent a valuable approach in selected adult patients.
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