ArticleScientific reports2020
Differential Role for a Defined Lateral Horn Neuron Subset in Naïve Odor Valence in Drosophila.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 32 citations in OpenAlex.
- Creating true and false memories from forgotten information in Drosophila.Nature neuroscience · 2026Article
- Differential dopaminergic modulation of the antennal lobe of Drosophila melanogaster.Communications biology · 2025Article
- Divergent synaptic dynamics originate parallel pathways for computation and behavior in an olfactory circuit.Current biology : CB · 2025Article
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- Nonlinear high-activity neuronal excitation enhances odor discrimination.Current biology : CB · 2025Article
- Impact of developmental temperature on neural growth, connectivity, and function.Science advances · 2025Article
- Neuronal circuit mechanisms of competitive interaction between action-based and coincidence learning.Science advances · 2024Article
- Sensory encoding and memory in the mushroom body: signals, noise, and variability.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Review
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- Homeostatic synaptic plasticity rescues neural coding reliability.Nature communications · 2023Article
- Lateral axonal modulation is required for stimulus-specific olfactory conditioning in Drosophila.Current biology : CB · 2022Article
- Olfactory stimuli and moonwalker SEZ neurons can drive backward locomotion in Drosophila.Current biology : CB · 2022Article
- GPCR voltage dependence controls neuronal plasticity and behavior.Nature communications · 2021Article
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- Olfactory processing in the lateral horn of Drosophila.Cell and tissue research · 2021Review
- Genetic Transsynaptic Techniques for Mapping Neural Circuits inFrontiers in neural circuits · 2021Review
- Neural Design Principles for Subjective Experience: Implications for Insects.Frontiers in behavioral neuroscience · 2021Article
- Complete Connectomic Reconstruction of Olfactory Projection Neurons in the Fly Brain.Current biology : CB · 2020Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Value coding of external stimuli in general, and odor valence in particular, is crucial for survival. In flies, odor valence is thought to be coded by two types of neurons: mushroom body output neurons (MBONs) and lateral horn (LH) neurons. MBONs are classified as neurons that promote either attraction or aversion, but not both, and they are dynamically activated by upstream neurons. This dynamic activation updates the valence values. In contrast, LH neurons receive scaled, but non-dynamic, input from their upstream neurons. It remains unclear how such a non-dynamic system generates differential valence values. Recently, PD2a1/b1 LH neurons were demonstrated to promote approach behavior at low odor concentration in starved flies. Here, we demonstrate that at high odor concentrations, these same neurons contribute to avoidance in satiated flies. The contribution of PD2a1/b1 LH neurons to aversion is context dependent. It is diminished in starved flies, although PD2a1/b1 neural activity remains unchanged, and at lower odor concentration. In addition, PD2a1/b1 aversive effect develops over time. Thus, our results indicate that, even though PD2a1/b1 LH neurons transmit hard-wired output, their effect on valence can change. Taken together, we suggest that the valence model described for MBONs does not hold for LH neurons.
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