Observational studyNeurology(R) neuroimmunology & neuroinflammation2020
Monitoring of radiologic disease activity by serum neurofilaments in MS.
Erratum issuedAbstract readObservational Study
In one paragraph
Observational study in Neurology(R) neuroimmunology & neuroinflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The role of serum neurofilament light (sNfL) as a biomarker in multiple sclerosis: insights from a systematic review.Journal of neurology · 2025Pooled it
- Plasma neurofilament light chain concentrations as a biomarker of clinical and radiologic outcomes in relapsing multiple sclerosis: Post hoc analysis of Phase 3 ozanimod trials.European journal of neurology · 2021Trial
- Bayes at the Bedside: Biomarkers in Situations of Clinical Uncertainty.Diagnostics (Basel, Switzerland) · 2026Article
- Associations Between Cardiovascular Risk Factors and Neurofilament Light Levels Among US Mexican American Adults.Brain and behavior · 2026Article
- Serum neurofilament light chain as a biomarker of disease control in multiple sclerosis: a real-world cross-sectional analysis of therapeutic regimens.Journal of neurology · 2025Article
- Personalized treatment decision algorithms for the clinical application of serum neurofilament light chain in multiple sclerosis: A modified Delphi Study.Multiple sclerosis (Houndmills, Basingstoke, England) · 2025Article
- Contribution of Blood Biomarkers to Multiple Sclerosis Diagnosis.Neurology(R) neuroimmunology & neuroinflammation · 2025Article
- Comparative analysis of neuroinflammatory pathways in Alzheimer's disease, Parkinson's disease, and multiple sclerosis: insights into similarities and distinctions.Frontiers in neuroscience · 2025Review
- Predictive value of individual serum neurofilament light chain levels in short-term disease activity in relapsing multiple sclerosis.Frontiers in neurology · 2024Article
- CSF Markers of Oxidative Stress Are Associated with Brain Atrophy and Iron Accumulation in a 2-Year Longitudinal Cohort of Early MS.International journal of molecular sciences · 2023Article
- Annual Plasma Neurofilament Dynamics Is a Sensitive Biomarker of Disease Activity in Patients with Multiple Sclerosis.Medicina (Kaunas, Lithuania) · 2023Article
- Serum neurofilament light in MS: The first true blood-based biomarker?Multiple sclerosis (Houndmills, Basingstoke, England) · 2022Review
- Current and Future Biomarkers in Multiple Sclerosis.International journal of molecular sciences · 2022Review
- Longitudinal tracking of axonal loss using diffusion magnetic resonance imaging in multiple sclerosis.Brain communications · 2022Article
- Natalizumab Versus Fingolimod in Patients with Relapsing-Remitting Multiple Sclerosis: A Subgroup Analysis From Three International Cohorts.CNS drugs · 2021Observational
- Cortical Thickness and Serum NfL Explain Cognitive Dysfunction in Newly Diagnosed Patients With Multiple Sclerosis.Neurology(R) neuroimmunology & neuroinflammation · 2021Article
- Chitinase 3-like 1 and neurofilament light chain in CSF and CNS atrophy in MS.Neurology(R) neuroimmunology & neuroinflammation · 2021Article
- Monitoring of radiologic disease activity by serum neurofilaments in MS.Neurology(R) neuroimmunology & neuroinflammation · 2021Article
- Serum Neurofilament Light Chain Measurement in MS: Hurdles to Clinical Translation.Frontiers in neuroscience · 2021Review
- Implications of extreme serum neurofilament light chain levels for the management of patients with relapsing multiple sclerosis.Therapeutic advances in neurological disorders · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
20 authors.
Tomas UherFrom the Department of Medicine (T.U., T.K.), CORe, The University of Melbourne, Victoria, Australia; Department of Neurology and Center of Clinical Neuroscience (T.U., B.S., M.T., K.V., E.K.H., D.H.), Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic; Clinical Trial Unit (S.S., P.B.), Department of Clinical Research, University Hospital Basel, University of Basel; Departments of Medicine, Biomedicine and Clinical Research (C.B., J.O., D.L., Y.N., L.K., J. Kuhle), Neurologic Clinic and Policlinic, University Hospital Basel, University of Basel, Switzerland; Department of Neurology, Jacobs School of Medicine and Biomedical Sciences (N.B., M.D., R.Z.), Buffalo Neuroimaging Analysis Center, University at Buffalo, State University of New York, Buffalo; IRCCS "S. Maria Nascente" (N.B.), Don Carlo Gnocchi Foundation, Milan, Italy; Department of Radiology (J. Krasensky, M.V.), Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Czech Republic; Center for Biomedical Imaging at Clinical Translational Science Institute (R.Z.), University at Buffalo, State University of New York, NY; and Department of Neurology (T.K.), The Royal Melbourne Hospital, Victoria, Australia. tomas.uher@vfn.cz.ORCID 0000-0003-3160-9022
Sabine SchaedelinFrom the Department of Medicine (T.U., T.K.), CORe, The University of Melbourne, Victoria, Australia; Department of Neurology and Center of Clinical Neuroscience (T.U., B.S., M.T., K.V., E.K.H., D.H.), Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic; Clinical Trial Unit (S.S., P.B.), Department of Clinical Research, University Hospital Basel, University of Basel; Departments of Medicine, Biomedicine and Clinical Research (C.B., J.O., D.L., Y.N., L.K., J. Kuhle), Neurologic Clinic and Policlinic, University Hospital Basel, University of Basel, Switzerland; Department of Neurology, Jacobs School of Medicine and Biomedical Sciences (N.B., M.D., R.Z.), Buffalo Neuroimaging Analysis Center, University at Buffalo, State University of New York, Buffalo; IRCCS "S. Maria Nascente" (N.B.), Don Carlo Gnocchi Foundation, Milan, Italy; Department of Radiology (J. Krasensky, M.V.), Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Czech Republic; Center for Biomedical Imaging at Clinical Translational Science Institute (R.Z.), University at Buffalo, State University of New York, NY; and Department of Neurology (T.K.), The Royal Melbourne Hospital, Victoria, Australia.
Barbora SrpovaFrom the Department of Medicine (T.U., T.K.), CORe, The University of Melbourne, Victoria, Australia; Department of Neurology and Center of Clinical Neuroscience (T.U., B.S., M.T., K.V., E.K.H., D.H.), Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic; Clinical Trial Unit (S.S., P.B.), Department of Clinical Research, University Hospital Basel, University of Basel; Departments of Medicine, Biomedicine and Clinical Research (C.B., J.O., D.L., Y.N., L.K., J. Kuhle), Neurologic Clinic and Policlinic, University Hospital Basel, University of Basel, Switzerland; Department of Neurology, Jacobs School of Medicine and Biomedical Sciences (N.B., M.D., R.Z.), Buffalo Neuroimaging Analysis Center, University at Buffalo, State University of New York, Buffalo; IRCCS "S. Maria Nascente" (N.B.), Don Carlo Gnocchi Foundation, Milan, Italy; Department of Radiology (J. Krasensky, M.V.), Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Czech Republic; Center for Biomedical Imaging at Clinical Translational Science Institute (R.Z.), University at Buffalo, State University of New York, NY; and Department of Neurology (T.K.), The Royal Melbourne Hospital, Victoria, Australia.
Christian BarroFrom the Department of Medicine (T.U., T.K.), CORe, The University of Melbourne, Victoria, Australia; Department of Neurology and Center of Clinical Neuroscience (T.U., B.S., M.T., K.V., E.K.H., D.H.), Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic; Clinical Trial Unit (S.S., P.B.), Department of Clinical Research, University Hospital Basel, University of Basel; Departments of Medicine, Biomedicine and Clinical Research (C.B., J.O., D.L., Y.N., L.K., J. Kuhle), Neurologic Clinic and Policlinic, University Hospital Basel, University of Basel, Switzerland; Department of Neurology, Jacobs School of Medicine and Biomedical Sciences (N.B., M.D., R.Z.), Buffalo Neuroimaging Analysis Center, University at Buffalo, State University of New York, Buffalo; IRCCS "S. Maria Nascente" (N.B.), Don Carlo Gnocchi Foundation, Milan, Italy; Department of Radiology (J. Krasensky, M.V.), Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Czech Republic; Center for Biomedical Imaging at Clinical Translational Science Institute (R.Z.), University at Buffalo, State University of New York, NY; and Department of Neurology (T.K.), The Royal Melbourne Hospital, Victoria, Australia.
Niels BergslandFrom the Department of Medicine (T.U., T.K.), CORe, The University of Melbourne, Victoria, Australia; Department of Neurology and Center of Clinical Neuroscience (T.U., B.S., M.T., K.V., E.K.H., D.H.), Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic; Clinical Trial Unit (S.S., P.B.), Department of Clinical Research, University Hospital Basel, University of Basel; Departments of Medicine, Biomedicine and Clinical Research (C.B., J.O., D.L., Y.N., L.K., J. Kuhle), Neurologic Clinic and Policlinic, University Hospital Basel, University of Basel, Switzerland; Department of Neurology, Jacobs School of Medicine and Biomedical Sciences (N.B., M.D., R.Z.), Buffalo Neuroimaging Analysis Center, University at Buffalo, State University of New York, Buffalo; IRCCS "S. Maria Nascente" (N.B.), Don Carlo Gnocchi Foundation, Milan, Italy; Department of Radiology (J. Krasensky, M.V.), Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Czech Republic; Center for Biomedical Imaging at Clinical Translational Science Institute (R.Z.), University at Buffalo, State University of New York, NY; and Department of Neurology (T.K.), The Royal Melbourne Hospital, Victoria, Australia.
Michael DwyerFrom the Department of Medicine (T.U., T.K.), CORe, The University of Melbourne, Victoria, Australia; Department of Neurology and Center of Clinical Neuroscience (T.U., B.S., M.T., K.V., E.K.H., D.H.), Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic; Clinical Trial Unit (S.S., P.B.), Department of Clinical Research, University Hospital Basel, University of Basel; Departments of Medicine, Biomedicine and Clinical Research (C.B., J.O., D.L., Y.N., L.K., J. Kuhle), Neurologic Clinic and Policlinic, University Hospital Basel, University of Basel, Switzerland; Department of Neurology, Jacobs School of Medicine and Biomedical Sciences (N.B., M.D., R.Z.), Buffalo Neuroimaging Analysis Center, University at Buffalo, State University of New York, Buffalo; IRCCS "S. Maria Nascente" (N.B.), Don Carlo Gnocchi Foundation, Milan, Italy; Department of Radiology (J. Krasensky, M.V.), Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Czech Republic; Center for Biomedical Imaging at Clinical Translational Science Institute (R.Z.), University at Buffalo, State University of New York, NY; and Department of Neurology (T.K.), The Royal Melbourne Hospital, Victoria, Australia.
Michaela TyblovaFrom the Department of Medicine (T.U., T.K.), CORe, The University of Melbourne, Victoria, Australia; Department of Neurology and Center of Clinical Neuroscience (T.U., B.S., M.T., K.V., E.K.H., D.H.), Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic; Clinical Trial Unit (S.S., P.B.), Department of Clinical Research, University Hospital Basel, University of Basel; Departments of Medicine, Biomedicine and Clinical Research (C.B., J.O., D.L., Y.N., L.K., J. Kuhle), Neurologic Clinic and Policlinic, University Hospital Basel, University of Basel, Switzerland; Department of Neurology, Jacobs School of Medicine and Biomedical Sciences (N.B., M.D., R.Z.), Buffalo Neuroimaging Analysis Center, University at Buffalo, State University of New York, Buffalo; IRCCS "S. Maria Nascente" (N.B.), Don Carlo Gnocchi Foundation, Milan, Italy; Department of Radiology (J. Krasensky, M.V.), Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Czech Republic; Center for Biomedical Imaging at Clinical Translational Science Institute (R.Z.), University at Buffalo, State University of New York, NY; and Department of Neurology (T.K.), The Royal Melbourne Hospital, Victoria, Australia.
Karolina VodehnalovaFrom the Department of Medicine (T.U., T.K.), CORe, The University of Melbourne, Victoria, Australia; Department of Neurology and Center of Clinical Neuroscience (T.U., B.S., M.T., K.V., E.K.H., D.H.), Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic; Clinical Trial Unit (S.S., P.B.), Department of Clinical Research, University Hospital Basel, University of Basel; Departments of Medicine, Biomedicine and Clinical Research (C.B., J.O., D.L., Y.N., L.K., J. Kuhle), Neurologic Clinic and Policlinic, University Hospital Basel, University of Basel, Switzerland; Department of Neurology, Jacobs School of Medicine and Biomedical Sciences (N.B., M.D., R.Z.), Buffalo Neuroimaging Analysis Center, University at Buffalo, State University of New York, Buffalo; IRCCS "S. Maria Nascente" (N.B.), Don Carlo Gnocchi Foundation, Milan, Italy; Department of Radiology (J. Krasensky, M.V.), Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Czech Republic; Center for Biomedical Imaging at Clinical Translational Science Institute (R.Z.), University at Buffalo, State University of New York, NY; and Department of Neurology (T.K.), The Royal Melbourne Hospital, Victoria, Australia.
Pascal BenkertFrom the Department of Medicine (T.U., T.K.), CORe, The University of Melbourne, Victoria, Australia; Department of Neurology and Center of Clinical Neuroscience (T.U., B.S., M.T., K.V., E.K.H., D.H.), Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic; Clinical Trial Unit (S.S., P.B.), Department of Clinical Research, University Hospital Basel, University of Basel; Departments of Medicine, Biomedicine and Clinical Research (C.B., J.O., D.L., Y.N., L.K., J. Kuhle), Neurologic Clinic and Policlinic, University Hospital Basel, University of Basel, Switzerland; Department of Neurology, Jacobs School of Medicine and Biomedical Sciences (N.B., M.D., R.Z.), Buffalo Neuroimaging Analysis Center, University at Buffalo, State University of New York, Buffalo; IRCCS "S. Maria Nascente" (N.B.), Don Carlo Gnocchi Foundation, Milan, Italy; Department of Radiology (J. Krasensky, M.V.), Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Czech Republic; Center for Biomedical Imaging at Clinical Translational Science Institute (R.Z.), University at Buffalo, State University of New York, NY; and Department of Neurology (T.K.), The Royal Melbourne Hospital, Victoria, Australia.ORCID 0000-0001-6525-8174
Johanna OechteringFrom the Department of Medicine (T.U., T.K.), CORe, The University of Melbourne, Victoria, Australia; Department of Neurology and Center of Clinical Neuroscience (T.U., B.S., M.T., K.V., E.K.H., D.H.), Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic; Clinical Trial Unit (S.S., P.B.), Department of Clinical Research, University Hospital Basel, University of Basel; Departments of Medicine, Biomedicine and Clinical Research (C.B., J.O., D.L., Y.N., L.K., J. Kuhle), Neurologic Clinic and Policlinic, University Hospital Basel, University of Basel, Switzerland; Department of Neurology, Jacobs School of Medicine and Biomedical Sciences (N.B., M.D., R.Z.), Buffalo Neuroimaging Analysis Center, University at Buffalo, State University of New York, Buffalo; IRCCS "S. Maria Nascente" (N.B.), Don Carlo Gnocchi Foundation, Milan, Italy; Department of Radiology (J. Krasensky, M.V.), Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Czech Republic; Center for Biomedical Imaging at Clinical Translational Science Institute (R.Z.), University at Buffalo, State University of New York, NY; and Department of Neurology (T.K.), The Royal Melbourne Hospital, Victoria, Australia.
David LeppertFrom the Department of Medicine (T.U., T.K.), CORe, The University of Melbourne, Victoria, Australia; Department of Neurology and Center of Clinical Neuroscience (T.U., B.S., M.T., K.V., E.K.H., D.H.), Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic; Clinical Trial Unit (S.S., P.B.), Department of Clinical Research, University Hospital Basel, University of Basel; Departments of Medicine, Biomedicine and Clinical Research (C.B., J.O., D.L., Y.N., L.K., J. Kuhle), Neurologic Clinic and Policlinic, University Hospital Basel, University of Basel, Switzerland; Department of Neurology, Jacobs School of Medicine and Biomedical Sciences (N.B., M.D., R.Z.), Buffalo Neuroimaging Analysis Center, University at Buffalo, State University of New York, Buffalo; IRCCS "S. Maria Nascente" (N.B.), Don Carlo Gnocchi Foundation, Milan, Italy; Department of Radiology (J. Krasensky, M.V.), Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Czech Republic; Center for Biomedical Imaging at Clinical Translational Science Institute (R.Z.), University at Buffalo, State University of New York, NY; and Department of Neurology (T.K.), The Royal Melbourne Hospital, Victoria, Australia.
Yvonne NaegelinFrom the Department of Medicine (T.U., T.K.), CORe, The University of Melbourne, Victoria, Australia; Department of Neurology and Center of Clinical Neuroscience (T.U., B.S., M.T., K.V., E.K.H., D.H.), Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic; Clinical Trial Unit (S.S., P.B.), Department of Clinical Research, University Hospital Basel, University of Basel; Departments of Medicine, Biomedicine and Clinical Research (C.B., J.O., D.L., Y.N., L.K., J. Kuhle), Neurologic Clinic and Policlinic, University Hospital Basel, University of Basel, Switzerland; Department of Neurology, Jacobs School of Medicine and Biomedical Sciences (N.B., M.D., R.Z.), Buffalo Neuroimaging Analysis Center, University at Buffalo, State University of New York, Buffalo; IRCCS "S. Maria Nascente" (N.B.), Don Carlo Gnocchi Foundation, Milan, Italy; Department of Radiology (J. Krasensky, M.V.), Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Czech Republic; Center for Biomedical Imaging at Clinical Translational Science Institute (R.Z.), University at Buffalo, State University of New York, NY; and Department of Neurology (T.K.), The Royal Melbourne Hospital, Victoria, Australia.
Jan KrasenskyFrom the Department of Medicine (T.U., T.K.), CORe, The University of Melbourne, Victoria, Australia; Department of Neurology and Center of Clinical Neuroscience (T.U., B.S., M.T., K.V., E.K.H., D.H.), Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic; Clinical Trial Unit (S.S., P.B.), Department of Clinical Research, University Hospital Basel, University of Basel; Departments of Medicine, Biomedicine and Clinical Research (C.B., J.O., D.L., Y.N., L.K., J. Kuhle), Neurologic Clinic and Policlinic, University Hospital Basel, University of Basel, Switzerland; Department of Neurology, Jacobs School of Medicine and Biomedical Sciences (N.B., M.D., R.Z.), Buffalo Neuroimaging Analysis Center, University at Buffalo, State University of New York, Buffalo; IRCCS "S. Maria Nascente" (N.B.), Don Carlo Gnocchi Foundation, Milan, Italy; Department of Radiology (J. Krasensky, M.V.), Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Czech Republic; Center for Biomedical Imaging at Clinical Translational Science Institute (R.Z.), University at Buffalo, State University of New York, NY; and Department of Neurology (T.K.), The Royal Melbourne Hospital, Victoria, Australia.
Manuela VaneckovaFrom the Department of Medicine (T.U., T.K.), CORe, The University of Melbourne, Victoria, Australia; Department of Neurology and Center of Clinical Neuroscience (T.U., B.S., M.T., K.V., E.K.H., D.H.), Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic; Clinical Trial Unit (S.S., P.B.), Department of Clinical Research, University Hospital Basel, University of Basel; Departments of Medicine, Biomedicine and Clinical Research (C.B., J.O., D.L., Y.N., L.K., J. Kuhle), Neurologic Clinic and Policlinic, University Hospital Basel, University of Basel, Switzerland; Department of Neurology, Jacobs School of Medicine and Biomedical Sciences (N.B., M.D., R.Z.), Buffalo Neuroimaging Analysis Center, University at Buffalo, State University of New York, Buffalo; IRCCS "S. Maria Nascente" (N.B.), Don Carlo Gnocchi Foundation, Milan, Italy; Department of Radiology (J. Krasensky, M.V.), Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Czech Republic; Center for Biomedical Imaging at Clinical Translational Science Institute (R.Z.), University at Buffalo, State University of New York, NY; and Department of Neurology (T.K.), The Royal Melbourne Hospital, Victoria, Australia.
Eva Kubala HavrdovaFrom the Department of Medicine (T.U., T.K.), CORe, The University of Melbourne, Victoria, Australia; Department of Neurology and Center of Clinical Neuroscience (T.U., B.S., M.T., K.V., E.K.H., D.H.), Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic; Clinical Trial Unit (S.S., P.B.), Department of Clinical Research, University Hospital Basel, University of Basel; Departments of Medicine, Biomedicine and Clinical Research (C.B., J.O., D.L., Y.N., L.K., J. Kuhle), Neurologic Clinic and Policlinic, University Hospital Basel, University of Basel, Switzerland; Department of Neurology, Jacobs School of Medicine and Biomedical Sciences (N.B., M.D., R.Z.), Buffalo Neuroimaging Analysis Center, University at Buffalo, State University of New York, Buffalo; IRCCS "S. Maria Nascente" (N.B.), Don Carlo Gnocchi Foundation, Milan, Italy; Department of Radiology (J. Krasensky, M.V.), Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Czech Republic; Center for Biomedical Imaging at Clinical Translational Science Institute (R.Z.), University at Buffalo, State University of New York, NY; and Department of Neurology (T.K.), The Royal Melbourne Hospital, Victoria, Australia.
Ludwig KapposFrom the Department of Medicine (T.U., T.K.), CORe, The University of Melbourne, Victoria, Australia; Department of Neurology and Center of Clinical Neuroscience (T.U., B.S., M.T., K.V., E.K.H., D.H.), Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic; Clinical Trial Unit (S.S., P.B.), Department of Clinical Research, University Hospital Basel, University of Basel; Departments of Medicine, Biomedicine and Clinical Research (C.B., J.O., D.L., Y.N., L.K., J. Kuhle), Neurologic Clinic and Policlinic, University Hospital Basel, University of Basel, Switzerland; Department of Neurology, Jacobs School of Medicine and Biomedical Sciences (N.B., M.D., R.Z.), Buffalo Neuroimaging Analysis Center, University at Buffalo, State University of New York, Buffalo; IRCCS "S. Maria Nascente" (N.B.), Don Carlo Gnocchi Foundation, Milan, Italy; Department of Radiology (J. Krasensky, M.V.), Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Czech Republic; Center for Biomedical Imaging at Clinical Translational Science Institute (R.Z.), University at Buffalo, State University of New York, NY; and Department of Neurology (T.K.), The Royal Melbourne Hospital, Victoria, Australia.
Robert ZivadinovFrom the Department of Medicine (T.U., T.K.), CORe, The University of Melbourne, Victoria, Australia; Department of Neurology and Center of Clinical Neuroscience (T.U., B.S., M.T., K.V., E.K.H., D.H.), Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic; Clinical Trial Unit (S.S., P.B.), Department of Clinical Research, University Hospital Basel, University of Basel; Departments of Medicine, Biomedicine and Clinical Research (C.B., J.O., D.L., Y.N., L.K., J. Kuhle), Neurologic Clinic and Policlinic, University Hospital Basel, University of Basel, Switzerland; Department of Neurology, Jacobs School of Medicine and Biomedical Sciences (N.B., M.D., R.Z.), Buffalo Neuroimaging Analysis Center, University at Buffalo, State University of New York, Buffalo; IRCCS "S. Maria Nascente" (N.B.), Don Carlo Gnocchi Foundation, Milan, Italy; Department of Radiology (J. Krasensky, M.V.), Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Czech Republic; Center for Biomedical Imaging at Clinical Translational Science Institute (R.Z.), University at Buffalo, State University of New York, NY; and Department of Neurology (T.K.), The Royal Melbourne Hospital, Victoria, Australia.
Dana HorakovaFrom the Department of Medicine (T.U., T.K.), CORe, The University of Melbourne, Victoria, Australia; Department of Neurology and Center of Clinical Neuroscience (T.U., B.S., M.T., K.V., E.K.H., D.H.), Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic; Clinical Trial Unit (S.S., P.B.), Department of Clinical Research, University Hospital Basel, University of Basel; Departments of Medicine, Biomedicine and Clinical Research (C.B., J.O., D.L., Y.N., L.K., J. Kuhle), Neurologic Clinic and Policlinic, University Hospital Basel, University of Basel, Switzerland; Department of Neurology, Jacobs School of Medicine and Biomedical Sciences (N.B., M.D., R.Z.), Buffalo Neuroimaging Analysis Center, University at Buffalo, State University of New York, Buffalo; IRCCS "S. Maria Nascente" (N.B.), Don Carlo Gnocchi Foundation, Milan, Italy; Department of Radiology (J. Krasensky, M.V.), Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Czech Republic; Center for Biomedical Imaging at Clinical Translational Science Institute (R.Z.), University at Buffalo, State University of New York, NY; and Department of Neurology (T.K.), The Royal Melbourne Hospital, Victoria, Australia.
Jens KuhleFrom the Department of Medicine (T.U., T.K.), CORe, The University of Melbourne, Victoria, Australia; Department of Neurology and Center of Clinical Neuroscience (T.U., B.S., M.T., K.V., E.K.H., D.H.), Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic; Clinical Trial Unit (S.S., P.B.), Department of Clinical Research, University Hospital Basel, University of Basel; Departments of Medicine, Biomedicine and Clinical Research (C.B., J.O., D.L., Y.N., L.K., J. Kuhle), Neurologic Clinic and Policlinic, University Hospital Basel, University of Basel, Switzerland; Department of Neurology, Jacobs School of Medicine and Biomedical Sciences (N.B., M.D., R.Z.), Buffalo Neuroimaging Analysis Center, University at Buffalo, State University of New York, Buffalo; IRCCS "S. Maria Nascente" (N.B.), Don Carlo Gnocchi Foundation, Milan, Italy; Department of Radiology (J. Krasensky, M.V.), Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Czech Republic; Center for Biomedical Imaging at Clinical Translational Science Institute (R.Z.), University at Buffalo, State University of New York, NY; and Department of Neurology (T.K.), The Royal Melbourne Hospital, Victoria, Australia.
Tomas KalincikFrom the Department of Medicine (T.U., T.K.), CORe, The University of Melbourne, Victoria, Australia; Department of Neurology and Center of Clinical Neuroscience (T.U., B.S., M.T., K.V., E.K.H., D.H.), Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic; Clinical Trial Unit (S.S., P.B.), Department of Clinical Research, University Hospital Basel, University of Basel; Departments of Medicine, Biomedicine and Clinical Research (C.B., J.O., D.L., Y.N., L.K., J. Kuhle), Neurologic Clinic and Policlinic, University Hospital Basel, University of Basel, Switzerland; Department of Neurology, Jacobs School of Medicine and Biomedical Sciences (N.B., M.D., R.Z.), Buffalo Neuroimaging Analysis Center, University at Buffalo, State University of New York, Buffalo; IRCCS "S. Maria Nascente" (N.B.), Don Carlo Gnocchi Foundation, Milan, Italy; Department of Radiology (J. Krasensky, M.V.), Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Czech Republic; Center for Biomedical Imaging at Clinical Translational Science Institute (R.Z.), University at Buffalo, State University of New York, NY; and Department of Neurology (T.K.), The Royal Melbourne Hospital, Victoria, Australia.ORCID 0000-0003-3778-1376
Funding
University of Buffalo Clinical and Translational Science Institute - Supplement SchulyerUL1TR001412 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MURPHY, TIMOTHY F · 2015 to 2024
$33.8MNCATS NIH HHS UL1 TR001412
Abstract
objectiveTo determine whether serum neurofilament light chain (sNfL) levels are associated with recent MRI activity in patients with relapsing-remitting MS (RRMS).
methodsThis observational study included 163 patients (405 samples) with early RRMS from the Study of Early interferon-beta1a (IFN-β1a) Treatment (SET) cohort and 179 patients (664 samples) with more advanced RRMS from the Genome-Wide Association Study of Multiple Sclerosis (GeneMSA) cohort. Based on annual brain MRI, we assessed the ability of sNfL cutoffs to reflect the presence of combined unique active lesions, defined as new/enlarging lesion compared with MRI in the preceding year or contrast-enhancing lesion. The probability of active MRI lesions among patients with different sNfL levels was estimated with generalized estimating equations models.
resultsFrom the sNfL samples ≥90th percentile, 81.6% of the SET (OR = 3.4, 95% CI = 1.8-6.4) and 48.9% of the GeneMSA cohort samples (OR = 2.6, 95% CI = 1.7-3.9) was associated with radiological disease activity on MRI. The sNfL level between the 10th and 30th percentile was reflective of negligible MRI activity: 1.4% (SET) and 6.5% (GeneMSA) of patients developed ≥3 active lesions, 5.8% (SET) and 6.5% (GeneMSA) developed ≥2 active lesions, and 34.8% (SET) and 11.8% (GeneMSA) showed ≥1 active lesion on brain MRI. The sNfL level <10th percentile was associated with even lower MRI activity. Similar results were found in a subgroup of clinically stable patients.
conclusionsLow sNfL levels (≤30th percentile) help identify patients with MS with very low probability of recent radiologic disease activity during the preceding year. This result suggests that in future, sNfL assessment may substitute the need for annual brain MRI monitoring in considerable number (23.1%-36.4%) of visits in clinically stable patients.
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Disease ProgressionAdultCohort StudiesFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedMultiple Sclerosis, Relapsing-RemittingNeurofilament ProteinsSensitivity and SpecificityYoung Adultneurofilament protein LNeurofilament Proteins
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