Evidence map›Paper›PMID 32273386›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Cytokinesis and postabscission midbody remnants are regulated during mammalian brain development.

Katrina C McNeely, Noelle D Dwyer

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact, top 100% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 0 citations in OpenAlex.

  1. Condensates on the Move: Midbody Remnants as Large, Translation-Competent Extracellular Vesicles.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  2. Review
  3. Article
  4. Non-transport functions of motor proteins in corticogenesis.Frontiers in cell and developmental biology · 2026
    Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. HIPK2 in the physiology of nervous system and its implications in neurological disorders.Biochimica et biophysica acta. Molecular cell research · 2023
    Review
  11. Article
  12. P53 independent pathogenic mechanisms contribute to BubR1 microcephaly.Frontiers in cell and developmental biology · 2023
    Article
  13. Review
  14. Article
  15. Cep55: abscission boss or assistant?Trends in cell biology · 2021
    Article
  16. Article
  17. Loss of Coiled-Coil Protein Cep55 Impairs Neural Stem Cell Abscission and Results in p53-Dependent Apoptosis in Developing Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Katrina C McNeelyDepartment of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908.ORCID 0000-0002-8156-8161
Noelle D DwyerDepartment of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908; ndwyer@virginia.edu.ORCID 0000-0002-1995-7203
University of Virginia · US

Funding

Roles of Cytokinesis in Polarized Neural Stem Cell Divisions and Brain GrowthR01NS076640 · NINDS · UNIVERSITY OF VIRGINIA · PI DWYER, NOELLE D · 2013 to 2017
$1.7M
Linking abscission defects to p53-dependent apoptosis in neural stem cellsR21NS106162 · NINDS · UNIVERSITY OF VIRGINIA · PI DWYER, NOELLE D · 2018 to 2019
$437k
NINDS NIH HHS R01 NS076640NINDS NIH HHS R21 NS106162
6 · The paper itself

Abstract

Building a brain of the proper size and structure requires neural stem cells (NSCs) to divide with tight temporal and spatial control to produce different daughter cell types in proper numbers and sequence. Mammalian NSCs in the embryonic cortex must maintain their polarized epithelial structure as they undergo both early proliferative divisions and later neurogenic divisions. To do this, they undergo a polarized form of cytokinesis at the apical membrane that is not well understood. Here, we investigate whether polarized furrowing and abscission in mouse NSCs are regulated differently at earlier and later stages and in a cytokinesis mutant,

Indexed as

Embryonic DevelopmentAnimalsAntibodiesBrainCytokinesisEmbryo, MammalianKinesinsMiceMice, KnockoutMice, TransgenicMutationNeural Stem CellsNeuronsAntibodiesKIF20B protein, mouseKinesinscytokinesismicrocephalymidbodymousestem cell

Identifiers

PMID32273386
PMCPMC7197019
OpenAlexW2983849274

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.