ArticleGenes & development2020
REDD1 loss reprograms lipid metabolism to drive progression of
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Article in Genes & development, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 56 citations in OpenAlex.
- REDD1/DDIT4 counteracts endoplasmic reticulum stress-induced apoptosis by controlling the expression of death receptor TRAILR2/DR5 in cancer cells.Cell death & disease · 2026Article
- Lipidomics and single-cell transcriptomics uncover aberrant lipid metabolism in metaplasia lesions during gastric carcinogenesis.Journal of gastroenterology · 2026Article
- Article
- The dual role of CD36 in cancer: from lipid metabolism to tumor microenvironment regulation.Molecular biology reports · 2025Review
- The roles of KRAS in cancer metabolism, tumor microenvironment and clinical therapy.Molecular cancer · 2025Review
- Targeting KRAS: from metabolic regulation to cancer treatment.Molecular cancer · 2025Review
- Mechanisms of drug resistance in nutrient-depleted colorectal cancer cells: insights into lysosomal and mitochondrial drug sequestration.Biology open · 2024Review
- Development of fatty acid metabolism score based on gene signature for predicting prognosis and immunotherapy response in colon cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024Article
- The stress-responsive protein REDD1 and its pathophysiological functions.Experimental & molecular medicine · 2023Review
- Melanin precursors mediated adaption to temperature changes in fungus and animal via inhibition of lipid-mediated ferroptosis.Science China. Life sciences · 2023Article
- Nuclear receptor modulators inhibit osteosarcoma cell proliferation and tumour growth by regulating the mTOR signaling pathway.Cell death & disease · 2023Article
- Lipid Metabolic Alterations in KRAS Mutant Tumors: Unmasking New Vulnerabilities for Cancer Therapy.International journal of molecular sciences · 2023Review
- A programmed cell death-related model based on machine learning for predicting prognosis and immunotherapy responses in patients with lung adenocarcinoma.Frontiers in immunology · 2023Article
- Benzo[ACS medicinal chemistry letters · 2022Article
- The mMolecular cancer · 2022Article
- Nutritional Sensor REDD1 in Cancer and Inflammation: Friend or Foe?International journal of molecular sciences · 2022Review
- CD36: an emerging therapeutic target for cancer and its molecular mechanisms.Journal of cancer research and clinical oncology · 2022Review
- Blocking REDD1/TXNIP Complex Ameliorates HG-Induced Renal Tubular Epithelial Cell Apoptosis and EMT through Repressing Oxidative Stress.International journal of endocrinology · 2022Article
- Resistance to immune checkpoint inhibitors in KRAS-mutant non-small cell lung cancer.Cancer drug resistance (Alhambra, Calif.) · 2022Review
- Glycolysis related gene expression signature in predicting prognosis of laryngeal squamous cell carcinoma.Bioengineered · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 3 institutions in 1 country.
Shuxi Qiao *Massachusetts General Hospital Cancer Center, Boston, Massachusetts 02114, USA.
Siang-Boon Koh *Massachusetts General Hospital Cancer Center, Boston, Massachusetts 02114, USA.
Varunika VivekanandanMassachusetts General Hospital Cancer Center, Boston, Massachusetts 02114, USA.
Devika SalunkeMassachusetts General Hospital Cancer Center, Boston, Massachusetts 02114, USA.
Krushna Chandra PatraMassachusetts General Hospital Cancer Center, Boston, Massachusetts 02114, USA.
Elma ZaganjorLudwig Cancer Center at Harvard, Harvard University, Boston, Massachusetts 02115, USA.
Kenneth RossMassachusetts General Hospital Cancer Center, Boston, Massachusetts 02114, USA.
Yusuke MizukamiMassachusetts General Hospital Cancer Center, Boston, Massachusetts 02114, USA.
Sarah JeanfavreBroad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.
Athena ChenHarvard Medical School, Boston, Massachusetts 02115, USA.
Mari Mino-KenudsonMassachusetts General Hospital Cancer Center, Boston, Massachusetts 02114, USA.
Sridhar RamaswamyMassachusetts General Hospital Cancer Center, Boston, Massachusetts 02114, USA.
Clary ClishBroad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.
Marcia HaigisLudwig Cancer Center at Harvard, Harvard University, Boston, Massachusetts 02115, USA.
Nabeel BardeesyMassachusetts General Hospital Cancer Center, Boston, Massachusetts 02114, USA.
Leif W EllisenMassachusetts General Hospital Cancer Center, Boston, Massachusetts 02114, USA.ORCID 0000-0003-0444-7910
Harvard University · USBroad Institute · USMassachusetts General Hospital · US
Funding
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6MFunction and mechanism of REDD1 signaling to TSC1/2 and mTORC1R01CA122589 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI ELLISEN, LEIF W · 2007 to 2017
$3.2MNCI NIH HHS R01 CA122589NIDDK NIH HHS P30 DK040561
Abstract
Human cancers with activating
Indexed as
AnimalsCell Line, TumorDisease ProgressionFatty AcidsHEK293 CellsHumansLipid MetabolismMiceMice, SCIDMutationOxidation-Reductionras ProteinsTranscription FactorsDdit4 protein, mouseFatty Acidsras ProteinsTranscription Factorsenergy stressfatty acid oxidationglycolysislipid metabolismlysophospholipidsmetastasisoxidative stressRASREDD1
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.