Evidence map›Paper›PMID 32272921›Full record

Observational studyBMC pulmonary medicine2020

Post hoc analysis of initial treatments and control status in the INITIAL study: an observational study of newly diagnosed patients with asthma.

Jiangtao Lin, Xiuhua Fu, Ping Jiang, Weidong Song, Xiaoyun Hu, Zhijun Jie, Chuntao Liu, Zhengguang He, Xiangdong Zhou, Huaping Tang

Registry-linked trialOpen access · goldAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC pulmonary medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02143739 (The Severity of Newly Diagnosed Asthma Patients and the Result of Initial 12 Weeks Treatment in China.), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02143739 completednot on this map

The Severity of Newly Diagnosed Asthma Patients and the Result of Initial 12 Weeks Treatment in China.

Typeobservational_patient_registrySponsorAstraZenecaRan2014 to 2016Enrolled4,817ConditionsAsthma
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 10 institutions in 1 country.

Jiangtao LinDepartment of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, No.2 Yinghua East Street, Chaoyang District, Beijing, 100029, China. jiangtao_l@263.net.
Xiuhua FuDepartment of Pulmonary and Critical Care Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010050, China.
Ping JiangDepartment of Respiratory Diseases, Tianjin First Center Hospital, Tianjin, 300192, China.
Weidong SongDepartment of Respiratory Diseases, Peking University Shenzhen Hospital, Shenzhen, 518035, China.
Xiaoyun HuDepartment of Respiratory Diseases, First Hospital of Shanxi Medical University, Taiyuan, 030001, China.
Zhijun JieDepartment of Respiratory Diseases, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, 200240, China.
Chuntao LiuDepartment of Respiratory Diseases, West China Hospital, Sichuan University, Chengdu, 610041, China.
Zhengguang HeDepartment of Respiratory Diseases, Suining Central Hospital, Suining, 629000, China.
Xiangdong ZhouDepartment of Respiratory Diseases, The First Hospital Affiliated to AMU (Southwest Hospital), Chongqing, 400030, China.
Huaping TangDepartment of Respiratory Diseases, Qingdao Municipal Hospital, Qingdao, 266000, China.
China-Japan Friendship Hospital · CNFirst Hospital of Shanxi Medical University · CNFudan University · CNInner Mongolia Medical University · CNPeking University Shenzhen Hospital · CNQingdao University · CNSichuan University · CNSouthwest Hospital · CNSuizhou Central Hospital · CNTianjin First Center Hospital · CN

Funding

Study design; collection, analysis, and interpretation of data; and medical writing support were funded by AstraZeneca, China. -
6 · The paper itself

Abstract

backgroundThe 12-week, multicentre, observational INITIAL study (NCT02143739) assessed asthma severity in newly diagnosed Chinese patients.

methodsPost hoc analysis of medication combinations prescribed per routine clinical practice at baseline, and the impact on control levels evaluated using 2012 vs 2018 Global Initiative for Asthma (GINA) criteria.

resultsIn total, 4491 patients were included in the analysis. At baseline, intermittent, mild, moderate and severe asthma was reported in 3.9, 12.0, 22.6 and 61.6% of patients, respectively. Most patients (90.2%) were prescribed inhaled corticosteroid/long-acting β

conclusionsAsthma control was not improved by adding LTRA to ICS/LABA and may have been unnecessary for some newly diagnosed patients. These findings were irrespective of the GINA criteria (2012 vs 2018) used and baseline severity.

Indexed as

Administration, InhalationAdrenal Cortex HormonesAdultAnti-Asthmatic AgentsAsthmaChinaDelayed-Action PreparationsDrug CombinationsFemaleHumansLeukotriene AntagonistsMaleMiddle AgedProspective StudiesSeverity of Illness IndexTime FactorsAdrenal Cortex HormonesAnti-Asthmatic AgentsDelayed-Action PreparationsDrug CombinationsLeukotriene AntagonistsGlobal initiative for asthmaInhaled corticosteroidLeukotriene receptor antagonistLong-acting β2 agonistSymptom control

Identifiers

PMID32272921
PMCPMC7147012
OpenAlexW3015297729

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.