Evidence map›Paper›PMID 32272719›Full record

ArticleMolecules (Basel, Switzerland)2020

Synthesis and Biological Evaluation of New Antitubulin Agents Containing 2-(3',4',5'-trimethoxyanilino)-3,6-disubstituted-4,5,6,7-tetrahydrothieno[2,3-

Romeo Romagnoli, Filippo Prencipe, Paola Oliva, Barbara Cacciari, Jan Balzarini, Sandra Liekens, Ernest Hamel, Andrea Brancale, Salvatore Ferla, Stefano Manfredini and 3 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 4 countries.

Romeo RomagnoliDipartimento di Scienze Chimiche e Farmaceutiche, University of Ferrara, Via L. Borsari 46, 44121 Ferrara, Italy.ORCID 0000-0002-6374-773X
Filippo PrencipeDipartimento di Scienze Chimiche e Farmaceutiche, University of Ferrara, Via L. Borsari 46, 44121 Ferrara, Italy.
Paola OlivaDipartimento di Scienze Chimiche e Farmaceutiche, University of Ferrara, Via L. Borsari 46, 44121 Ferrara, Italy.
Barbara CacciariDipartimento di Scienze Chimiche e Farmaceutiche, University of Ferrara, Via L. Borsari 46, 44121 Ferrara, Italy.
Jan BalzariniLaboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, B-3000 Leuven, Belgium.
Sandra LiekensLaboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, B-3000 Leuven, Belgium.
Ernest HamelScreening Technologies Branch, Developmental for Cancer Research, National Cancer Institute, National Institute of Health, Frederick, MD 21702, USA.
Andrea BrancaleSchool of Pharmacy and Pharmaceutical Sciences, Cardiff University, King Edward VII Avenue, Cardiff CF10 3NB, UK.
Salvatore FerlaSchool of Pharmacy and Pharmaceutical Sciences, Cardiff University, King Edward VII Avenue, Cardiff CF10 3NB, UK.
Stefano ManfrediniDipartimento di Scienze della Vita e Biotecnologie, Università di Ferrara, 44121 Ferrara, Italy.ORCID 0000-0003-1348-4422
Matteo ZurloDipartimento di Scienze della Vita e Biotecnologie, Università di Ferrara, 44121 Ferrara, Italy.ORCID 0000-0002-6131-3727
Alessia FinottiDipartimento di Scienze della Vita e Biotecnologie, Università di Ferrara, 44121 Ferrara, Italy.ORCID 0000-0002-7638-515X
Roberto GambariDipartimento di Scienze della Vita e Biotecnologie, Università di Ferrara, 44121 Ferrara, Italy.
University of Ferrara · ITCardiff University · GBRega Institute for Medical Research · BENational Cancer Institute · US

Funding

Associazione Italiana per la Ricerca sul Cancro IG 13575Life Science Research Network Wales NRNPGSep14008Ministero dell'Istruzione, dell'Università e della Ricerca 2017E84AA4_002
6 · The paper itself

Abstract

Two novel series of compounds based on the 4,5,6,7-tetrahydrothieno[2,3-

Indexed as

AnimalsAntineoplastic AgentsApoptosisBiological ProductsCell DeathCell DivisionCell LineCell Line, TumorCell ProliferationColchicineDrug Screening Assays, AntitumorG2 PhaseHeLa CellsHumansK562 CellsLeukocytes, MononuclearAntineoplastic AgentsBiological ProductsColchicinepyridinePyridinesTubulinTubulin Modulatorsantiproliferative activitymicrotubulesstructure–activity relationshiptetrahydrothieno[2,3-c]pyridinetubulin

Identifiers

PMID32272719
PMCPMC7181277
OpenAlexW3015761855

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.