Evidence map›Paper›PMID 32272661›Full record

ReviewPathogens (Basel, Switzerland)2020

Papillomaviruses Go Retro.

Jian Xie, Pengwei Zhang, Mac Crite, Daniel DiMaio

Abstract readReview
In one paragraph

Review in Pathogens (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. The Rab5 effector Rabankyrin-5 mediates endosomal fusion and trafficking of human papillomavirus during early entry.Proceedings of the National Academy of Sciences of the United States of America · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jian XieDepartment of Genetics, Yale School of Medicine, P.O. Box 208005, New Haven, CT 06520-8005, USA.
Pengwei ZhangDepartment of Genetics, Yale School of Medicine, P.O. Box 208005, New Haven, CT 06520-8005, USA.
Mac CriteDepartment of Microbial Pathogenesis, Yale School of Medicine, 295 Congress Avenue, New Haven, CT 06519, USA.
Daniel DiMaioDepartment of Genetics, Yale School of Medicine, P.O. Box 208005, New Haven, CT 06520-8005, USA.ORCID 0000-0002-2060-5977

Funding

VIRAL SMALL RNPS--ROLES IN CELL TRANSFORMATIONP01CA016038 · NCI · YALE UNIVERSITY · PI DIMAIO, DANIEL C. · 1985 to 2020
$25.6M
Predoctoral Training Program in VirologyT32AI055403 · NIAID · YALE UNIVERSITY · PI KUMAR, PRITI, MOTHES, WALTHER H · 2003 to 2024
$3.6M
Role of Retromer-mediated Retrograde Transport in HPV EntryR01AI102876 · NIAID · YALE UNIVERSITY · PI DIMAIO, DANIEL C. · 2013 to 2020
$3.1M
NCI NIH HHS P01 CA016038NIAID NIH HHS R01 AI102876NIAID NIH HHS T32 AI055403NIH HHS P01 CA016038NIH HHS R01 AI102876NIH HHS T32 AI055403
6 · The paper itself

Abstract

Human papillomaviruses are important pathogens responsible for approximately 5% of cancer as well as other important human diseases, but many aspects of the papillomavirus life cycle are poorly understood. To undergo genome replication, HPV DNA must traffic from the cell surface to the nucleus. Recent findings have revolutionized our understanding of HPV entry, showing that it requires numerous cellular proteins and proceeds via a series of intracellular membrane-bound vesicles that comprise the retrograde transport pathway. This paper reviews the evidence supporting this unique entry mechanism with a focus on the crucial step by which the incoming virus particle is transferred from the endosome into the retrograde pathway. This new understanding provides novel insights into basic cellular biology and suggests novel rational approaches to inhibit HPV infection.

Indexed as

cell-penetrating peptidecervical cancerendosomeHPVpapillomavirusretrograde traffickingretromervirus entryγ-secretase

Identifiers

PMID32272661
PMCPMC7238053

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.