Evidence map›Paper›PMID 32272629›Full record

ArticleAntibiotics (Basel, Switzerland)2020

Taurolidine Acts on Bacterial Virulence Factors and Does Not Induce Resistance in Periodontitis-Associated Bacteria-An In-Vitro Study.

Sabrina Radakovic, Nicola Andreoli, Simon Schmid, Sandor Nietzsche, Jürg Zumbrunn, Anton Sculean, Sigrun Eick

Open access · goldAbstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. First-in-Human Intramediastinal Taurolidine Irrigation forJournal of cardiovascular development and disease · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. The European TauroPace™ Registry.Methods and protocols · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Sabrina RadakovicDepartment of Periodontology, School of Dental Medicine, University of Bern, CH-3010 Bern, Switzerland.
Nicola AndreoliDepartment of Periodontology, School of Dental Medicine, University of Bern, CH-3010 Bern, Switzerland.
Simon SchmidDepartment of Periodontology, School of Dental Medicine, University of Bern, CH-3010 Bern, Switzerland.
Sandor NietzscheCenter for Electron Microscopy, Jena University Hospital, D-07743 Jena, Germany.
Jürg ZumbrunnDepartment of Clinical Affairs R& D, Geistlich Pharma Ag, CH-6110 Wolhusen, Switzerland.
Anton SculeanDepartment of Periodontology, School of Dental Medicine, University of Bern, CH-3010 Bern, Switzerland.
Sigrun EickDepartment of Periodontology, School of Dental Medicine, University of Bern, CH-3010 Bern, Switzerland.
University of Bern · CHGeistlich Pharma (Switzerland) · CHJena University Hospital · DE

Funding

Geistlich Pharma AG, Wolhusen, Switzerland not applicable
6 · The paper itself

Abstract

The aims of the present study were: (a) to determine the mechanism of action of taurolidine against bacterial species associated with periodontal disease, and (b) to evaluate the potential development of resistance against taurolidine as compared with minocycline. After visualizing the mode of action of taurolidine by transmission electron micrographs, the interaction with most important virulence factors (lipopolysaccharide (LPS),

Indexed as

development of resistancemechanisms of actionminocyclineperiodontal pathogenstaurolidine

Identifiers

PMID32272629
PMCPMC7235838
OpenAlexW3015334630

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.