Observational studyNutrients2020
Predictors of Response to Exclusive Enteral Nutrition in Newly Diagnosed Crohn´s Disease in Children: PRESENCE Study from SEGHNP.
Open access · goldAbstract readMulticenter StudyObservational Study
In one paragraph
Observational study in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- The Role of Partial Enteral Nutrition for Induction of Remission in Crohn's Disease: A Systematic Review of Controlled Trials.Nutrients · 2022Pooled it
- The attitudes and beliefs of Australasian pediatric gastroenterologists and dietitians toward the Crohn's disease exclusion diet.JPGN reports · 2026Article
- Exclusive enteral nutrition in Crohn's disease pediatric patients: from clinical remission to transmural healing.Medicine and pharmacy reports · 2025Article
- Review
- Considerations in Paediatric and Adolescent Inflammatory Bowel Disease.Journal of Crohn's & colitis · 2024Review
- Mechanisms of Action of Exclusive Enteral Nutrition and Other Nutritional Therapies in Crohn's Disease.Nutrients · 2024Review
- Exclusive enteral nutrition for treating pediatric Crohn's disease.World journal of pediatrics : WJP · 2024Article
- Revolution in diet therapy for inflammatory bowel disease.JGH open : an open access journal of gastroenterology and hepatology · 2024Review
- The Bidirectional Link between Nutritional Factors and Inflammatory Bowel Diseases: Dietary Deficits, Habits, and Recommended Interventions-A Narrative Review.Foods (Basel, Switzerland) · 2023Review
- Repeated and multiple fecal microbiota transplantations plus partial enteral nutrition as the first-line treatment in active pediatric Crohn's disease.Frontiers in cellular and infection microbiology · 2023Article
- Review
- [Effectiveness of induction therapy with exclusive enteral nutrition in pediatric Crohn's disease].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Article
- The SES-CD Could Be a Predictor of Short- and Long-Term Mucosal Healing After Exclusive Enteral Nutrition in Pediatric Crohn's Disease Patients.Frontiers in pediatrics · 2022Article
- Diet and Nutrition in Pediatric Inflammatory Bowel Diseases.Nutrients · 2021Review
- Article
- Nutritional Therapy Strategies in Pediatric Crohn's Disease.Nutrients · 2021Review
- EEN Yesterday and Today … CDED Today and Tomorrow.Nutrients · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
50 authors at 20 institutions in 1 country.
Melinda MoricziPaediatric Gastroenterology and Nutrition Unit, Hospital Complex Torrecárdenas, 04009 Almeria, Spain.
Gemma Pujol-MuncunillDepartment of Paediatric Gastroenterology, Hepatology and Nutrition, Hospital Sant Joan de Déu, Esplugues del Llobregat, 08950 Barcelona, Spain.ORCID 0000-0002-9660-5826
Rafael Martín-MasotPaediatric Gastroenterology and Nutrition Unit, Regional University Hospital of Malaga, 29011 Málaga, Spain.ORCID 0000-0003-0113-9904
Santiago Jiménez TreviñoGastroenterology Unit, Hepatology and Nutrition, Central University Hospital of Asturias, 33011 Oviedo, Spain.
Oscar Segarra CantónPaediatric Gastroenterology, Hepatology and Nutrition Unit, University Hospital Vall d'Hebron, 08035 Barcelona, Spain.
Carlos Ochoa SangradorPaediatric Gastroenterology, Hepatology and Nutrition Unit, Hospital Virgen de la Concha, 49022 Zamora, Spain.ORCID 0000-0002-7670-3699
Luis Peña QuintanaPaediatric Gastroenterology, Hepatology and Nutrition Unit, Maternal-Child Hospital, 35016 Las Palmas of Gran Canaria, Spain.
Daniel González SantanaPaediatric Gastroenterology, Hepatology and Nutrition Unit, Maternal-Child Hospital, 35016 Las Palmas of Gran Canaria, Spain.
Alejandro Rodríguez MartínezPaediatric Gastroenterology, Hepatology and Nutrition Unit, Hospital Virgen del Rocío, 41013 Seville, Spain.
Antonio Rosell CampsPaediatric Gastroenterology and Nutrition Unit, University Hospital Son Espases, 07010 Palma de Mallorca, Spain.
Honorio ArmasPaediatric Gastroenterology, Hepatology and Nutrition Unit, University Hospital of the Canary Islands, 38320 Tenerife, Spain.
Josefa BarrioPaediatric Gastroenterology, Hepatology and Nutrition Unit, University Hospital Fuenlabrada, Fuenlabrada, 28942 Madrid, Spain.
Rafael González de CaldasPaediatric Gastroenterology, Hepatology and Nutrition Unit, Hospital Reina Sofía, 14004 Cordoba, Spain.
Mónica Rodríguez SalasPaediatric Gastroenterology, Hepatology and Nutrition Unit, Hospital Reina Sofía, 14004 Cordoba, Spain.
Elena Balmaseda SerranoPaediatric Gastroenterology, Hepatology and Nutrition Unit, Hospital Complex, University of Albacete, 02008 Albacete, Spain.
Ester Donat AliagaPaediatric Gastroenterology, Hepatology and Nutrition Unit, University Hospital La Fe, 46009 Valencia, Spain.ORCID 0000-0002-0114-6445
Andrés Bodas PinedoPaediatric Gastroenterology, Hepatology and Nutrition Unit, Hospital Clinic San Carlos, 28040 Madrid, Spain.
Esther Vaquero SosaPaediatric Gastroenterology, Hepatology and Nutrition Unit, Hospital Clinic San Carlos, 28040 Madrid, Spain.
Raquel Vecino LópezPaediatric Gastroenterology, Hepatology and Nutrition Unit, Hospital Clinic San Carlos, 28040 Madrid, Spain.
Alfonso Solar BogaPaediatric Gastroenterology, Hepatology and Nutrition Unit, Maternal-Child Hospital Teresa Herrera, 15004 A Coruña, Spain.
Ana Moreno ÁlvarezPaediatric Gastroenterology, Hepatology and Nutrition Unit, Maternal-Child Hospital Teresa Herrera, 15004 A Coruña, Spain.
César Sánchez SánchezPaediatric Gastroenterology, Hepatology and Nutrition Unit, General University Hospital Gregorio Marañón, 28009 Madrid, Spain.
Mar Tolín HernaniPaediatric Gastroenterology, Hepatology and Nutrition Unit, General University Hospital Gregorio Marañón, 28009 Madrid, Spain.
Carolina Gutiérrez JunqueraPaediatric Gastroenterology, Hepatology and Nutrition Unit, University Hospital Puerta de Hierro, 28220 Majadahonda, Madrid, Spain.ORCID 0000-0003-0313-7072
Nazareth Martinón TorresPaediatric Gastroenterology, Hepatology and Nutrition Unit, University Hospital Clinic of Santiago, 15706 Santiago de Compostela, Spain.
María Rosaura Leis TrabazoPaediatric Gastroenterology, Hepatology and Nutrition Unit, University Hospital Clinic of Santiago, 15706 Santiago de Compostela, Spain.ORCID 0000-0002-0540-4210
Francisco Javier EizaguirrePaediatric Gastroenterology, Hepatology and Nutrition Unit, University Hospital of Donostia, 20006 San Sebastian, Spain.
Mónica García PerisPaediatric Gastroenterology, Hepatology and Nutrition Unit, Hospital Lluís Alcanyís, Xátiva, 46800 Valencia, Spain.
Enrique Medina BenítezPaediatric Gastroenterology, Hepatology and Nutrition Unit, Hospital 12 de Octubre, 28041 Madrid, Spain.
Beatriz Fernández CaamañoPaediatric Gastroenterology, Hepatology and Nutrition Unit, Hospital Álvaro Cunqueiro, 36213 Vigo, Spain.
Ana María Vegas ÁlvarezPaediatric Gastroenterology, Hepatology and Nutrition Unit, Hospital Río Hortega, 47012 Valladolid, Spain.
Laura Crespo ValderrábanoPaediatric Gastroenterology, Hepatology and Nutrition Unit, Hospital Río Hortega, 47012 Valladolid, Spain.
Carmen Alonso VicentePaediatric Gastroenterology, Hepatology and Nutrition Unit, Hospital Río Hortega, 47012 Valladolid, Spain.
Javier Rubio SantiagoPaediatric Gastroenterology, Hepatology and Nutrition Unit, Hospital de Jerez, 11408 Jerez de la Frontera, Cádiz, Spain.
Rafael Galera-MartínezPaediatric Gastroenterology and Nutrition Unit, Hospital Complex Torrecárdenas, 04009 Almeria, Spain.
Ruth García-RomeroPaediatric Gastroenterology, Hepatology and Nutrition Unit, Paediatric Hospital Miguel Servet, 50009 Zaragoza, Spain.
Ignacio Ros ArnalPaediatric Gastroenterology, Hepatology and Nutrition Unit, Paediatric Hospital Miguel Servet, 50009 Zaragoza, Spain.
Santiago Fernández CebriánPaediatric Gastroenterology, Hepatology and Nutrition Unit, University Hospital Complex Ourense, 32616 Ourense, Spain.
Helena Lorenzo GarridoPaediatric Gastroenterology, Hepatology and Nutrition Unit, Hospital Basurto, Bilbao, 48013 Vizcaya, Spain.
Javier Francisco Viada BrisPaediatric Gastroenterology, Hepatology and Nutrition Unit, University Hospital Niño Jesús, 28009 Madrid, Spain.
Marta Velasco Rodríguez-BelvisPaediatric Gastroenterology, Hepatology and Nutrition Unit, University Hospital Niño Jesús, 28009 Madrid, Spain.ORCID 0000-0003-2844-313X
Juan Manuel Bartolomé PorroPaediatric Gastroenterology, Hepatology and Nutrition Unit, Hospital Río Carrión, 34005 Palencia, Spain.
Miriam Blanco RodríguezPaediatric Gastroenterology, Hepatology and Nutrition Unit, Jiménez Díaz Foundation, 28040 Madrid, Spain.
Patricia Barros GarcíaPaediatric Gastroenterology, Hepatology and Nutrition Unit, Hospital San Pedro de Alcántara, 10003 Cáceres, Spain.
Gonzalo BotijaPaediatric Gastroenterology, Hepatology and Nutrition Unit, Alcorcón Foundation, 28922 Alcorcón, Madrid, Spain.
Francisco José Chicano MarínPaediatric Gastroenterology, Hepatology and Nutrition Unit, University Hospital Los Arcos del Mar Menor, 30739 Pozo Aledo, Murcia, Spain.
Enrique La Orden IzquierdoPaediatric Gastroenterology, Hepatology and Nutrition Unit, University Hospital Infanta Sofía, 28709 San Sebastián de los Reyes, Madrid, Spain.
Elena Crehuá-GaudizaPaediatric Gastroenterology, Hepatology and Nutrition Unit, University Clinical Hospital, 46010 Valencia, Spain.ORCID 0000-0001-7135-6539
Víctor Manuel Navas-LópezPaediatric Gastroenterology and Nutrition Unit, Regional University Hospital of Malaga, 29011 Málaga, Spain.ORCID 0000-0003-3004-252X
Javier Martín-de-CarpiDepartment of Paediatric Gastroenterology, Hepatology and Nutrition, Hospital Sant Joan de Déu, Esplugues del Llobregat, 08950 Barcelona, Spain.
Hospital Clínico San Carlos · ESHospital Materno-Infantil · ESComplejo Hospitalario Torrecárdenas · ESHospital General Universitario Gregorio Marañón · ESHospital Infantil Universitario Niño Jesús · ESHospital Regional Universitario de Málaga · ESHospital Sant Joan de Déu Barcelona · ESHospital Universitario Miguel Servet · ESHospital Universitario Reina Sofía · ESHospital Universitario Río Hortega · ESUniversidad de Las Palmas de Gran Canaria · ESBiogipuzkoa Health Research Institute · ESComplejo Hospitalario de Ourense · ESHospital Clínico Universitario de Valencia · ESHospital de Basurto · ESHospital General Universitario de Albacete · ESHospital General Universitario Los Arcos del Mar Menor · ESHospital Jerez Puerta del Sur · ESHospital Rio Carrion · ESHospital San Pedro de Alcántara · ES
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exclusive enteral nutrition (EEN) has been shown to be more effective than corticosteroids in achieving mucosal healing in children with Crohn´s disease (CD) without the adverse effects of these drugs. The aims of this study were to determine the efficacy of EEN in terms of inducing clinical remission in children newly diagnosed with CD, to describe the predictive factors of response to EEN and the need for treatment with biological agents during the first 12 months of the disease. We conducted an observational retrospective multicentre study that included paediatric patients newly diagnosed with CD between 2014-2016 who underwent EEN. Two hundred and twenty-two patients (140 males) from 35 paediatric centres were included, with a mean age at diagnosis of 11.6 ± 2.5 years. The median EEN duration was 8 weeks (IQR 6.6-8.5), and 184 of the patients (83%) achieved clinical remission (weighted paediatric Crohn's Disease activity index [wPCDAI] < 12.5). Faecal calprotectin (FC) levels (μg/g) decreased significantly after EEN (830 [IQR 500-1800] to 256 [IQR 120-585]
Indexed as
Enteral NutritionAdolescentChildCrohn DiseaseFemaleHumansMaleRemission InductionRetrospective StudiescalprotectinchildrenCrohn’s diseaseexclusive enteral nutritioninflammatory bowel diseasepaediatric
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