Evidence map›Paper›PMID 32272559›Full record

ArticleInternational journal of molecular sciences2020

Recombinant Human Plasma Gelsolin Stimulates Phagocytosis while Diminishing Excessive Inflammatory Responses in Mice with

Ewelina Piktel, Urszula Wnorowska, Mateusz Cieśluk, Piotr Deptuła, Suhanya V Prasad, Grzegorz Król, Bonita Durnaś, Andrzej Namiot, Karolina H Markiewicz, Katarzyna Niemirowicz-Laskowska and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Ewelina PiktelDepartment of Medical Microbiology and Nanobiomedical Engineering, Medical University of Bialystok, Mickiewicza 2c, 15-222 Bialystok, Poland.
Urszula WnorowskaDepartment of Medical Microbiology and Nanobiomedical Engineering, Medical University of Bialystok, Mickiewicza 2c, 15-222 Bialystok, Poland.
Mateusz CieślukDepartment of Medical Microbiology and Nanobiomedical Engineering, Medical University of Bialystok, Mickiewicza 2c, 15-222 Bialystok, Poland.ORCID 0000-0002-5931-4376
Piotr DeptułaDepartment of Medical Microbiology and Nanobiomedical Engineering, Medical University of Bialystok, Mickiewicza 2c, 15-222 Bialystok, Poland.ORCID 0000-0003-3553-3774
Suhanya V PrasadDepartment of Medical Microbiology and Nanobiomedical Engineering, Medical University of Bialystok, Mickiewicza 2c, 15-222 Bialystok, Poland.
Grzegorz KrólDepartment of Microbiology and Immunology, the Faculty of Medicine and Health Sciences of the Jan Kochanowski University in Kielce, Stefana Żeromskiego 5, 25-001 Kielce, Poland.
Bonita DurnaśDepartment of Microbiology and Immunology, the Faculty of Medicine and Health Sciences of the Jan Kochanowski University in Kielce, Stefana Żeromskiego 5, 25-001 Kielce, Poland.
Andrzej NamiotDepartment of Anatomy, Medical University of Bialystok, Mickiewicza 2b, 15-222 Bialystok, Poland.
Karolina H MarkiewiczInstitute of Chemistry, University of Białystok, Ciołkowskiego 1K, 15-245 Bialystok, Poland.
Katarzyna Niemirowicz-LaskowskaDepartment of Medical Microbiology and Nanobiomedical Engineering, Medical University of Bialystok, Mickiewicza 2c, 15-222 Bialystok, Poland.ORCID 0000-0002-3311-7147
Agnieszka Z WilczewskaInstitute of Chemistry, University of Białystok, Ciołkowskiego 1K, 15-245 Bialystok, Poland.
Paul A JanmeyInstitute for Medicine and Engineering, University of Pennsylvania, 3340 Smith Walk, Philadelphia, PA 19104, USA.
Joanna ReszećDepartment of Pathology, Medical University of Bialystok, Waszyngtona 13, 15-269 Bialystok, Poland.
Robert BuckiDepartment of Medical Microbiology and Nanobiomedical Engineering, Medical University of Bialystok, Mickiewicza 2c, 15-222 Bialystok, Poland.ORCID 0000-0001-7664-9226
Medical University of Białystok · PLJan Kochanowski University · PLUniversity of Białystok · PLUniversity of Pennsylvania · US

Funding

Narodowe Centrum Nauki UMO-2015/17/B/NZ6/03473NIH HHS GM111942Uniwersytet Medyczny w Bialymstoku N/ST/MN/18/001/1162Uniwersytet Medyczny w Bialymstoku N/ST/ZB/18/001/1162
6 · The paper itself

Abstract

Plasma gelsolin (pGSN) is a highly conserved abundant circulating protein, characterized by diverse immunomodulatory activities including macrophage activation and the ability to neutralize pro-inflammatory molecules produced by the host and pathogen. Using a murine model of Gram-negative sepsis initiated by the peritoneal instillation of

Indexed as

AnimalsAnti-Bacterial AgentsBacteriaCell LineGelsolinHumansInflammationMacrophagesMicePhagocytosisPlasmaPseudomonas aeruginosaPseudomonas InfectionsRAW 264.7 CellsRecombinant ProteinsSepsisAnti-Bacterial AgentsGelsolinRecombinant Proteinsinflammationphagocytosisplasma gelsolinPseudomonas aeruginosasepsis

Identifiers

PMID32272559
PMCPMC7177774
OpenAlexW3014666145

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.