ArticleNeuroImage. Clinical2020
Rotating frame MRI relaxations as markers of diffuse white matter abnormalities in multiple sclerosis.
Article in NeuroImage. Clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- In vivo quantitative imaging of hippocampal inflammation in autoimmune neuroinflammatory conditions: a systematic review.Clinical and experimental immunology · 2022Pooled it
- Altering MRI rotating frame relaxations by changing the truncation level of Hyperbolic Secant pulse.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2026Article
- Elevated Corpus Callosum T1rho Reflects Disease Burden and Structural Atrophy in Multiple Sclerosis.Diagnostics (Basel, Switzerland) · 2026Article
- RJournal of magnetic resonance (San Diego, Calif. : 1997) · 2026Article
- Enhancing MRI contrast between sub-chronic myocardial infarct, remote and healthy myocardium using periodic irradiation in the rotating frames.Scientific reports · 2026Article
- Latent brain-cognition dimension indicative of neuroinflammatory basis of Long COVID.Brain communications · 2026Article
- Enhancing contrast between sub-chronic myocardial infarct, remote and healthy myocardium using periodic irradiation in the rotating frames.Research square · 2025Article
- Clinical and MRI Correlates of β-Amyloid Load Inconsistent With Its Presumed Neurotoxicity in Cognitively Healthy Ageing.Journal of neurochemistry · 2025Article
- Microstructural abnormalities in multiple system atrophy as revealed by conventional and rotating frame relaxation MRI parameters.Scientific reports · 2025Article
- On the geometric phase effects on time evolution of the density matrix during modulated radiofrequency pulses.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2025Article
- Different Grey Matter Microstructural Patterns in Cognitively Healthy Versus Typical Ageing Healthy Versus Typical Brain Ageing.NMR in biomedicine · 2025Article
- Complete solution for rotating frame relaxation functions during adiabatic pulses.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2025Article
- Reducing thermal noise in high-resolution quantitative magnetic resonance imaging rotating frame relaxation mapping of the human brain at 3 T.NMR in biomedicine · 2024Article
- Novel spin-lock time sampling strategies for improved reproducibility in quantitative T1ρ mapping.NMR in biomedicine · 2024Article
- Sleep quality and the integrity of ascending reticular activating system - A multimodal MRI study.Heliyon · 2024Article
- Wide-spread brain alterations early after the onset of Crohn's disease in children in remission-a pilot study.Frontiers in neuroscience · 2024Article
- Distance from main arteries influences microstructural and functional brain tissue characteristics.NeuroImage · 2024Article
- Brain MRI Biomarkers in Isolated Rapid Eye Movement Sleep Behavior Disorder: Where Are We? A Systematic Review.Brain sciences · 2023Review
- Utility of quantitative MRI metrics in brain ageing research.Frontiers in aging neuroscience · 2023Article
- Neuroprotection and neuroregeneration: roles for the white matter.Neural regeneration research · 2022Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 4 countries.
Funding
Abstract
Even though MRI visualization of white matter lesions is pivotal for the diagnosis and management of multiple sclerosis (MS), the issue of detecting diffuse brain tissue damage beyond the apparent T2-hyperintense lesions continues to spark considerable interest. Motivated by the notion that rotating frame MRI methods are sensitive to slow motional regimes critical for tissue characterization, here we utilized novel imaging protocols of rotating frame MRI on a clinical 3 Tesla platform, including adiabatic longitudinal, T1ρ, and transverse, T2ρ, relaxation methods, and Relaxation Along a Fictitious Field (RAFF) in the rotating frame of rank 4 (RAFF4), in 10 relapsing-remitting multiple sclerosis patients and 10 sex- and age-matched healthy controls. T1ρ, T2ρ and RAFF4 relaxograms extracted from the whole white matter exhibited a significant shift towards longer relaxation time constants in MS patients as compared to controls. T1ρ and RAFF4 detected alterations even when considering only regions of normally appearing white matter (NAWM), while other MRI metrics such as T1w/T2w ratio and diffusion tensor imaging measures failed to find group differences. In addition, RAFF4, T2ρ and, to a lesser extent, T1ρ showed differences in subcortical grey matter structures, mainly hippocampus, whereas no functional changes in this region were detected in resting-state functional MRI metrics. We conclude that rotating frame MRI techniques are exceptionally sensitive methods for the detection of subtle abnormalities not only in NAWM, but also in deep grey matter in MS, where they surpass even highly sensitive measures of functional changes, which are often suggested to precede detectable structural alterations. Such abnormalities are consistent with a wide spectrum of different, but interconnected pathological features of MS, including the loss of neuronal cells and their axons, decreased levels of myelin even in NAWM, and altered iron content.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.