Evidence map›Paper›PMID 32272333›Full record

ReviewSeizure2020

Controversies on the network theory of epilepsy: Debates held during the ICTALS 2019 conference.

Hitten P Zaveri, Björn Schelter, Catherine A Schevon, Premysl Jiruska, John G R Jefferys, Gregory Worrell, Andreas Schulze-Bonhage, Rasesh B Joshi, Viktor Jirsa, Marc Goodfellow and 2 more

Abstract readReview
In one paragraph

Review in Seizure, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Trial
  2. A complex network perspective on brain disease.Biological reviews of the Cambridge Philosophical Society · 2026
    Review
  3. An update on the network theory of epilepsy.Frontiers in network physiology · 2026
    Article
  4. Editorial: The network theory of epilepsy at twenty.Frontiers in network physiology · 2026
    Article
  5. Article
  6. Article
  7. The role of neuromodulation in the management of drug-resistant epilepsy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Review
  8. Article
  9. Networks through the lens of high-frequency oscillations.Frontiers in network physiology · 2024
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Distinct Features of Interictal Activity Predict Seizure Localization and Burden in a Mouse Model of Childhood Epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hitten P ZaveriDepartment of Neurology, Yale University, New Haven, CT 06520, USA.
Björn SchelterInstitute for Complex Systems and Mathematical Biology, University of Aberdeen, Aberdeen AB24 3UE, UK.
Catherine A SchevonDepartment of Neurology, Columbia University, New York, NY, USA.
Premysl JiruskaDepartment of Physiology, Second Faculty of Medicine, Charles University, Prague, Czech Republic.
John G R JefferysDepartment of Physiology, Second Faculty of Medicine, Charles University, Prague, Czech Republic; Department of Pharmacology, University of Oxford, Oxford OX1 3QT, UK.
Gregory WorrellMayo Systems Electrophysiology Laboratory, Departments of Neurology and Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.
Andreas Schulze-BonhageEpilepsy Center, University Medical Center Freiburg, Freiburg, Germany.
Rasesh B JoshiDepartment of Neurobiology and Anatomy, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Viktor JirsaInstitut de Neurosciences des Systèmes, Aix Marseille University, Marseille, France.
Marc GoodfellowLiving Systems Institute, University of Exeter, Exeter, UK; Wellcome Trust Centre for Biomedical Modelling and Analysis, University of Exeter, Exeter, UK; EPSRC Centre for Predictive Modelling in Healthcare, University of Exeter, Exeter, UK.
Christian MeiselDepartment of Neurology, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115, USA; Department of Neurology, University Clinic Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany.
Klaus LehnertzDepartment of Epileptology, University of Bonn, Venusberg Campus 1, 53127 Bonn, Germany; Interdisciplinary Center for Complex Systems, University of Bonn, Brühler Str. 7, 53175 Bonn, Germany. Electronic address: Klaus.Lehnertz@ukbonn.de.

Funding

Network analysis for epilepsy surgeryR01NS109062 · NINDS · YALE UNIVERSITY · PI EID, TORE, ZAVERI, HITTEN P · 2019 to 2022
$1.5M
NINDS NIH HHS R01 NS109062Wellcome Trust
6 · The paper itself

Abstract

Debates on six controversial topics on the network theory of epilepsy were held during two debate sessions, as part of the International Conference for Technology and Analysis of Seizures, 2019 (ICTALS 2019) convened at the University of Exeter, UK, September 2-5 2019. The debate topics were (1) From pathologic to physiologic: is the epileptic network part of an existing large-scale brain network? (2) Are micro scale recordings pertinent for defining the epileptic network? (3) From seconds to years: do we need all temporal scales to define an epileptic network? (4) Is it necessary to fully define the epileptic network to control it? (5) Is controlling seizures sufficient to control the epileptic network? (6) Does the epileptic network want to be controlled? This article, written by the organizing committee for the debate sessions and the debaters, summarizes the arguments presented during the debates on these six topics.

Indexed as

Congresses as TopicEpilepsyHumansNerve NetEdgesEpileptic networkEpileptogenesisIctogenesisNodesSeizure control

Identifiers

PMID32272333
PMCPMC7952007

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.