Evidence map›Paper›PMID 32272077›Full record

ReviewCell host & microbe2020

The Biology of the HIV-1 Latent Reservoir and Implications for Cure Strategies.

Lillian B Cohn, Nicolas Chomont, Steven G Deeks

Registry-linked trialAbstract readReview
In one paragraph

Review in Cell host & microbe, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06250881 (Analysis of Ocular Complications of AIDS Patients in Ophthalmic Consultation), which is not on this map. Cited by 206 papers.

0numbers the graph read from it
0cells of the map it votes in
206citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06250881 unknown statusnot on this mapstarted 2023, after this paper: background citation

Analysis of Ocular Complications of AIDS Patients in Ophthalmic Consultation

TypeobservationalSponsorZhongnan HospitalRan2023 to 2024Enrolled500ConditionsOcular Complications in AIDS Patients, Such as Fundus Opportunistic Infections, Microangiopathy, and Uveitis
3 · Its place in the literature

Who cites it

206 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Article
  7. HCV-specific CD4EBioMedicine · 2026
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Recurrent mutations drive rapid HIV escape from two broadly neutralizing antibodies in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  17. Review
  18. Article
  19. Review
  20. Article

146 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lillian B CohnChan Zuckerberg Biohub, San Francisco, CA; Department of Medicine, University of California, San Francisco, CA.
Nicolas ChomontCentre de recherche du CHUM and Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montreal, QC, Canada.
Steven G DeeksDepartment of Medicine, University of California, San Francisco, CA. Electronic address: steven.deeks@ucsf.edu.

Funding

Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MALLORY O JOHNSON · 1988 to 2026
$93.6M
Delaney AIDS Research Enterprise to Cure HIVUM1AI126611 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DEEKS, STEVEN GRANT, PICKER, LOUIS J. · 2016 to 2020
$27.9M
Canadian Institutes of HealthNIAID NIH HHS P30 AI027763NIAID NIH HHS UM1 AI126611
6 · The paper itself

Abstract

Antiretroviral therapy (ART) inhibits HIV replication but is not curative. During ART, the integrated HIV genome persists indefinitely within CD4

Indexed as

HIV-1HIV InfectionsVirus LatencyAcquired Immunodeficiency SyndromeAge FactorsAnimalsAnti-Retroviral AgentsAntiretroviral Therapy, Highly ActiveBiomarkersB-LymphocytesCD4-Positive T-LymphocytesCoinfectionHost Microbial InteractionsHumansSex FactorsViral LoadAnti-Retroviral AgentsBiomarkers

Identifiers

PMID32272077
PMCPMC7219958

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.