ArticleInvestigative ophthalmology & visual science2020
Morphometric, Hemodynamic, and Biomechanical Factors Influencing Blood Flow and Oxygen Concentration in the Human Lamina Cribrosa.
Article in Investigative ophthalmology & visual science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Biaxial Mechanical Behavior of the Choroid and Its Effect on Ocular Trauma Simulations.Investigative ophthalmology & visual science · 2026Article
- AI to Identify Strain-Sensitive Regions of the Optic Nerve Head Linked to Functional Loss in Glaucoma.Investigative ophthalmology & visual science · 2026Article
- Differential Effects of Corneal Biomechanics on Superficial and Deep Vessel Density and Their Association with Central Visual Function in Glaucoma Patients with Myopia.Journal of clinical medicine · 2025Article
- Lamina Cribrosa Hypoxia Sensitivity to Variations of Anatomy and Vascular Factors.Journal of biomechanical engineering · 2025Article
- Biomechanical Strain Responses in the Sclera, Choroid, and Retina in Glaucoma Patients After Intraocular Pressure Lowering.Journal of biomechanical engineering · 2025Article
- The Strain Response to Intraocular Pressure Increase in the Lamina Cribrosa of Control Subjects and Glaucoma Patients.Translational vision science & technology · 2024Article
- Comparing IOP-Induced Scleral Deformations in the Myopic and Myopic Glaucoma Spectrums.Investigative ophthalmology & visual science · 2024Article
- Impact of anatomic variability and other vascular factors on lamina cribrosa hypoxia.bioRxiv : the preprint server for biology · 2024Article
- Impact of elevated IOP on lamina cribrosa oxygenation; A combined experimental-computational study on monkeys.bioRxiv : the preprint server for biology · 2024Article
- The Robust Lamina Cribrosa Vasculature: Perfusion and Oxygenation Under Elevated Intraocular Pressure.Investigative ophthalmology & visual science · 2024Article
- Optic nerve head factors associated with initial central visual field defect in primary open-angle glaucoma.Scientific reports · 2024Article
- Peripapillary vessels density is closely related to cerebral white matter hyperintensities: An OCTA study.PloS one · 2024Article
- Super-Resolution Ultrasound Localization Microscopy Using High-Frequency Ultrasound to Measure Ocular Perfusion Velocity in the Rat Eye.Bioengineering (Basel, Switzerland) · 2023Article
- Optical Coherence Tomography Angiography Demonstrates Strain and Volume Effects on Optic Disk and Peripapillary Vasculature Caused by Horizontal Duction.Current eye research · 2023Article
- Computational Modeling of Ophthalmic Procedures: Computational Modeling of Ophthalmic Procedures.American journal of ophthalmology · 2022Article
- Eye-specific 3D modeling of factors influencing oxygen concentration in the lamina cribrosa.Experimental eye research · 2022Article
- A Workflow for Three-Dimensional Reconstruction and Quantification of the Monkey Optic Nerve Head Vascular Network.Journal of biomechanical engineering · 2022Article
- Impact of Elevated Intraocular Pressure on Lamina Cribrosa Oxygenation: A Combined Experimental-Computational Study on Monkeys.Ophthalmology scienceArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: We developed a combined biomechanical and hemodynamic model of the human eye to estimate blood flow and oxygen concentration within the lamina cribrosa (LC) and rank the factors that influence LC oxygen concentration. Methods: We generated 5000 finite-element eye models with detailed microcapillary networks of the LC and computed the oxygen concentration of the lamina retinal ganglion cell axons. For each model, we varied the intraocular pressure (IOP) from 10 mm Hg to 55 mm Hg in 5-mm Hg increments, the cerebrospinal fluid pressure (13 ± 2 mm Hg), cup depth (0.2 ± 0.1 mm), scleral stiffness (±20% of the mean values), LC stiffness (0.41 ± 0.2 MPa), LC radius (1.2 ± 0.12 mm), average LC pore size (5400 ± 2400 µm2), the microcapillary arrangement (radial, isotropic, or circumferential), and perfusion pressure (50 ± 9 mm Hg). Blood flow was assumed to originate from the LC periphery and drain via the central retinal vein. Finally, we performed linear regressions to rank the influence of each factor on the LC tissue oxygen concentration. Results: LC radius and perfusion pressure were the most important factors in influencing the oxygen concentration of the LC. IOP was another important parameter, and eyes with higher IOP had higher compressive strain and slightly lower oxygen concentration. In general, superior-inferior regions of the LC had significantly lower oxygen concentration than the nasal-temporal regions, resulting in an hourglass pattern of oxygen deficiency. Conclusions: To the best of our knowledge, this study is the first to implement a comprehensive hemodynamical model of the eye that accounts for the biomechanical forces and morphological parameters of the LC. The results provide further insight into the possible relationship of biomechanical and vascular pathways leading to ischemia-induced optic neuropathy.
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