ArticlePloS one2020
Trends of syphilis in Brazil: A growth portrait of the treponemic epidemic.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Computational methods applied to syphilis: where are we, and where are we going?Frontiers in public health · 2023Pooled it
- Diagnostic tools for neurosyphilis: a systematic review.BMC infectious diseases · 2021Pooled it
- The neglected role of partner treatment in congenital syphilis control in Brazil: nationwide evidence from 2007 to 2023.Lancet regional health. Americas · 2026Article
- Epidemiological profile, completeness of notifications, and factors associated with the adequacy of treatment for syphilis during pregnancy: a cross-sectional study, Ubá, 2018-2023.Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil · 2026Article
- Hospitalizations for congenital infections in Brazil's unified health system: nationwide trends and regional disparities, 2008-2024.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2026Article
- Risk factors and prevalence of Human Immunodeficiency Virus and Syphilis, among prisoners in Duhok city, Kurdistan Region, Iraq.BMC infectious diseases · 2025Article
- Assessing the impact of HIV self-testing on diagnosis rates in vulnerable groups in belo horizonte, Brazil: A cross-sectional analysis.Public health in practice (Oxford, England) · 2025Article
- Trends in Congenital Syphilis Incidence and Mortality in Brazil's Southeast Region: A Time-Series Analysis (2008-2022).Epidemiologia (Basel, Switzerland) · 2025Article
- Age-related associations between heavy drinking and inconsistent condom use among unmarried adults: results from the Brazilian National Health Survey.Cadernos de saude publica · 2025Article
- Prenatal syphilis and adverse pregnancy outcomes in women with HIV receiving ART in Brazil: a population-based study.Lancet regional health. Americas · 2024Article
- Exposure toPathogens (Basel, Switzerland) · 2024Article
- Seroprevalence of Treponema pallidum infection in Brazilian indigenous people: a cross-sectional study.Scientific reports · 2024Article
- Acquired syphilis in older people in Brazil from 2010-2020.PloS one · 2024Article
- Congenital syphilis, syphilis in pregnancy and prenatal care in Brazil: An ecological study.PloS one · 2024Article
- Associated factors, incidence, and management of gestational and congenital syphilis in a Brazilian state capital: a cross-sectional study.Revista do Instituto de Medicina Tropical de Sao Paulo · 2024Article
- Challenges and Solutions to STI Control in the Era of HIV and STI Prophylaxis.Current HIV/AIDS reports · 2023Review
- Exposure toMicroorganisms · 2023Article
- Estimating the real burden of gestational syphilis in Brazil, 2007-2018: a Bayesian modeling study.Lancet regional health. Americas · 2023Article
- Salus Platform: A Digital Health Solution Tool for Managing Syphilis Cases in Brazil-A Comparative Analysis.International journal of environmental research and public health · 2023Article
- Syphilis detection rate trend in aged people: Brazil, 2011-2019.Revista brasileira de epidemiologia = Brazilian journal of epidemiology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Syphilis is a chronic infectious disease with its prevalence being described since the 15th century. Although its etiological agent and also the treatment measures are widely known, syphilis is still a great public health problem worldwide, mainly in countries with limited resources associated to low investments in health primary care. The aim of the present study was to analyze the trend and regional distribution of syphilis in Brazil between 2007 and 2017. This is an ecological study using secondary data from the Brazilian notification system. The Ministry of Health selected 100 municipalities which presented the worse outcomes related to syphilis from the 5,570 Brazilian municipalities as a target for a comprehensive project in order to tackle the prevalence of syphilis, called the "No Syphilis Project". These priority municipalities represent 57.7% of syphilis cases and about one third of the Brazilian population. They were compared with other 189 non-priority municipalities with more than 100 thousand inhabitants among the Brazilian regions (North, Northeast, Southeast, South and Center-West). Polynomial regression methods and Joinpoint analyses were used to analyze the trend, from which the Annual Average Percent Change (AACP) for each time period was calculated. There was a significant growth trend in all regions for the main three forms of syphilis (in pregnancy, congenital and acquired), especially in the South. The ratio between syphilis in pregnancy and congenital syphilis increased in both priority (AAPC: 8.54%; p<0.001) and non-priority municipalities (AAPC: 2.61%; p = 0.005), as well as in the regions, except the Center-West. High growth trends in syphilis prevalence were found in all municipalities, as well as all five regions between 2007 and 2017, showing that the challenge to reduce or even eliminate syphilis in Brazil is still difficult.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.