Will Complement Inhibition Be the New Target in Treating COVID-19-Related Systemic Thrombosis?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

170 citing papers in PubMed, 7 syntheses or guidelines pooled it.

1. Revised Guidelines for Coronavirus Disease 19 Management in Hematopoietic Cell Transplantation and Cellular Therapy Recipients (August 2022).Transplantation and cellular therapy · 2022
   Guideline
2. Risk of ischemic stroke in patients with COVID-19 infection: A systematic review and meta-analysis.Brain research bulletin · 2022
   Pooled it
3. COVID-19 and coagulation dysfunction in adults: A systematic review and meta-analysis.Journal of medical virology · 2021
   Pooled it
4. Anticoagulation in COVID-19: A Systematic Review, Meta-analysis, and Rapid Guidance From Mayo Clinic.Mayo Clinic proceedings · 2020
   Pooled it
5. Guidelines for COVID-19 Management in Hematopoietic Cell Transplantation and Cellular Therapy Recipients.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2020
   Guideline
6. Cerebral ischemic and hemorrhagic complications of coronavirus disease 2019.International journal of stroke : official journal of the International Stroke Society · 2020
   Pooled it
7. COMDORA-SBN recommendations for patients with rare kidney diseases in relation to the Covid-19 pandemic.Jornal brasileiro de nefrologia · 2020
   Guideline
8. Complement system component dysregulation is a distinctive feature of COVID-19 disease: a prospective and comparative analysis of patients admitted to the emergency department for suspected COVID-19 disease.Journal of thrombosis and thrombolysis · 2022
   Trial
9. Complement Overactivation and Consumption Predicts In-Hospital Mortality in SARS-CoV-2 Infection.Frontiers in immunology · 2021
   Trial
10. Proteolytic profiling of human plasma reveals an immunoactive complement C3 fragment.The EMBO journal · 2025
    Article
11. Afucosylated IgG Promote Thrombosis in Mouse Injected with SARS-CoV-2 Spike Expressing Megakaryocytes.International journal of molecular sciences · 2025
    Article
12. Decoding the mechanism of Qingjie formula in the prevention of COVID-19 based on network pharmacology and molecular docking.Heliyon · 2024
    Article
13. Esophageal ulcer and multisystem inflammatory syndrome after COVID-19: A case report.World journal of gastrointestinal endoscopy · 2024
    Article
14. Thyroid tuberculosis and cold abscess after infection with COVID-19: A case report.Heliyon · 2024
    Article
15. Acute neutrophilic vasculitis (leukocytoclasia) in 36 COVID-19 autopsy brains.Diagnostic pathology · 2024
    Article
16. How the immune response to the structural proteins of SARS-CoV-2 affects the retinal vascular endothelial cells: an immune thrombotic and/or endotheliopathy process with in silico modeling.Immunologic research · 2024
    Article
17. COVID-19 Increases the Risk of New Myocardial Infarction in Patients with Old Myocardial Infarction: A Retrospective Observational Study.Clinical Medicine Insights. Cardiology · 2024
    Article
18. Complement factor D targeting protects endotheliopathy in organoid and monkey models of COVID-19.Cell stem cell · 2023
    Article
19. Association of Serum Complement C3 Levels with Severity and Mortality in COVID 19.Indian journal of clinical biochemistry : IJCB · 2023
    Article
20. Pathological Effects of SARS-CoV-2 Associated with Hematological Abnormalities.Current issues in molecular biology · 2023
    Review

110 more citing papers are in PubMed but not listed here.

Corrections and comments

• Comment on
  Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China.2020

Authors and funding

2 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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