Evidence map›Paper›PMID 32271569›Full record

ArticleJournal of medicinal chemistry2020

Truncated (N)-Methanocarba Nucleosides as Partial Agonists at Mouse and Human A

Dilip K Tosh, Veronica Salmaso, Harsha Rao, Amelia Bitant, Courtney L Fisher, David I Lieberman, Helmut Vorbrüggen, Marc L Reitman, Oksana Gavrilova, Zhan-Guo Gao and 2 more

Open access · greenAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 19 citations in OpenAlex.

  1. 4'-Thionucleosides as adenosine AMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Review
  2. 2-Substituted (N)-Methanocarba AACS pharmacology & translational science · 2024
    Article
  3. First Potent Macrocyclic AACS pharmacology & translational science · 2023
    Article
  4. Assay-Dependent Inverse Agonism at the AACS pharmacology & translational science · 2023
    Article
  5. Species dependence of APurinergic signalling · 2023
    Review
  6. Fluorescent APurinergic signalling · 2023
    Article
  7. Review
  8. Selective AACS medicinal chemistry letters · 2022
    Article
  9. Review
  10. AEuropean journal of medicinal chemistry · 2022
    Article
  11. Article
  12. Review
  13. Design and Synthesis of 2,6-Disubstituted-4'-Selenoadenosine-5'-Pharmaceuticals (Basel, Switzerland) · 2021
    Article
  14. Review
  15. Review
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Dilip K Tosh
Veronica Salmaso
Harsha Rao
Amelia BitantDepartment of Pharmacology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, United States.
Courtney L FisherDepartment of Pharmacology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, United States.
David I Lieberman
Helmut VorbrüggenInstitut für Chemie und Biochemie, Freie Universität, Takustraße 3, D-14195 Berlin, Germany.
Marc L Reitman
Oksana Gavrilova
Zhan-Guo Gao
John A AuchampachDepartment of Pharmacology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, United States.
Kenneth A JacobsonORCID 0000-0001-8104-1493
National Institutes of Health · USMedical College of Wisconsin · USFreie Universität Berlin · DE

Funding

Metabolic Studies of Mouse Models of Obesity and DiabetesZICDK070002 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI GAVRILOVA, OKSANA · 2009 to 2025
$15.0M
Development Of Drugs Acting At Adenosine ReceptorsZIADK031117 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 2009 to 2025
$10.4M
Computer Modeling of G Protein-Coupled ReceptorsZIADK031126 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 2009 to 2025
$6.6M
What can body temperature tell us about energy homeostasis?ZIADK075063 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI REITMAN, MARC L · 2012 to 2025
$5.6M
Pharmacologic approaches to the treatment of obesityZIADK075062 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI REITMAN, MARC L · 2012 to 2025
$5.5M
Adenosine Signaling During Post-Infarction Remodeling and Heart FailureR01HL133589 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI AUCHAMPACH, JOHN A · 2017 to 2020
$1.7M
Intramural NIH HHS ZIA DK031117Intramural NIH HHS ZIA DK075063NHLBI NIH HHS R01 HL133589NIMH NIH HHS HHSN271200800025C
6 · The paper itself

Abstract

Dopamine-derived

Indexed as

Adenosine A3 Receptor AgonistsAnimalsDose-Response Relationship, DrugHEK293 CellsHumansMaleMiceMice, Inbred C57BLMice, KnockoutNucleosidesProtein BindingProtein Structure, SecondaryReceptor, Adenosine A3Adenosine A3 Receptor AgonistsNucleosidesReceptor, Adenosine A3

Identifiers

PMID32271569
PMCPMC7443318
OpenAlexW3015783635

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.