SynthesisInternational braz j urol : official journal of the Brazilian Society of Urology
Partial nephrectomy provides equivalent oncologic outcomes and better renal function preservation than radical nephrectomy for pathological T3a renal cell carcinoma: A meta-analysis.
Synthesis in International braz j urol : official journal of the Brazilian Society of Urology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Competing-Risk Regression Analysis of Cancer-Specific and Other-Cause Mortality after Partial versus Radical Nephrectomy in T3aN0M0 Renal Cell Carcinoma.Annals of surgical oncology · 2026Article
- Machine learning prediction of overall survival in patients with cT1b renal cell carcinoma after surgical resection using the SEER database.Scientific reports · 2025Article
- [A retrospective matching study of partial nephrectomy and radical nephrectomy for pathological T3a stage renal cell carcinoma].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2025Article
- Surgical Strategies in Renal Cancer: A Meta-analysis of Partial vs. Radical Nephrectomy Outcomes Across Tumor Stages.Qatar medical journal · 2025Review
- Three-dimensional visualization techniques improve surgical Decision Making of robotic-assisted partial nephrectomy.Heliyon · 2024Article
- [Predicting the 3-year tumor-specific survival in patients with TBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2024Article
- A systematic review of robot-assisted partial nephrectomy outcomes for advanced indications: Large tumors (cT2-T3), solitary kidney, completely endophytic, hilar, recurrent, and multiple renal tumors.Asian journal of urology · 2023Review
- Adverse pathologic features impact survival outcomes for small renal masses following nephrectomy.Urologic oncology · 2023Article
- Robotic PartialJournal of endourology · 2023Review
- Long-Term Oncological and Functional Outcomes After Robot-Assisted Partial Nephrectomy for Clinically Localized Renal Cell Carcinoma.Annals of surgical oncology · 2022Article
- Review
- Validation of the Mayo Adhesive Probability score as a predictor of adherent perinephric fat and outcomes in open partial nephrectomy.Translational andrology and urology · 2021Article
- Partial and Radical Nephrectomy Provides Equivalent Oncologic Outcomes in pT3a Renal Cell Carcinoma: A Population-Based Study.Frontiers in oncology · 2021Article
- Robot-assisted partial nephrectomy for large complex renal cancer: step-by-step segmental artery unclamping.International braz j urol : official journal of the Brazilian Society of UrologyArticle
- Partial laparoscopic nephrectomy: what really matters?International braz j urol : official journal of the Brazilian Society of UrologyArticle
- Comparison of oncologic outcomes between partial nephrectomy and radical nephrectomy in patients who were upstaged from cT1 renal tumor to pT3a renal cell carcinoma: an updated systematic review and meta-analysis.Therapeutic advances in urologyArticle
- How to draw the line between partial and radical nephrectomy.International braz j urol : official journal of the Brazilian Society of UrologyArticle
- Practical evaluation of the R.E.N.A.L. score system in 150 laparoscopic nephron sparing surgeries.International braz j urol : official journal of the Brazilian Society of UrologyArticle
- A novel nomogram can predict pathological T3a upstaged from clinical T1a in localized renal cell carcinoma.International braz j urol : official journal of the Brazilian Society of UrologyArticle
- A decisive year to International Brazilian Journal of Urology.International braz j urol : official journal of the Brazilian Society of UrologyArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeRadical nephrectomy (RN) is the standard surgical type for pathological stage T3a (pT3a) renal cell carcinoma (RCC). Recently, some studies have suggested equivalence between partial nephrectomy (PN) and RN for oncologic control and have shown the benefits of PN for better renal function. We conducted this meta-analysis to assess oncologic outcomes, perioperative outcomes and renal function between two groups among patients with pT3a RCC. MATERIALS AND
methodsPubMed, Scopus, Web of Science, Science Direct, Ovid MEDLINE, The Cochrane Library, Embase and Google Scholar were searched for eligible articles. The endpoints of the final analysis included overall survival (OS), cancer-specific survival (CSS), recurrence-free survival (RFS), surgical complications, operative time, estimated blood loss (EBL), serum creatinine and estimated glomerular filtration rate (eGFR).
resultsTwelve studies of moderate to high quality, including 14.152 patients, were examined. PN showed superiority for renal functional preservation, providing higher eGFR (WMD=12.48mL/min; 95%CI: 10.28 to 14.67; P < 0.00001) and lower serum creatinine (WMD=-0.31mg/dL; 95%CI: -0.40 to -0.21; P < 0.00001). There were no significant differences between PN and RN regarding operative time, EBL, surgical complications, OS, RFS and CSS. Despite inherent selection bias, most pooled estimates were consistent in sensitivity analysis and subgroup analysis. More positive margins were found in the PN group (RR=2.42; 95%CI: 1.25-4.68; P=0.009).
conclusionsPN may be more suitable for treating pT3a RCC than RN because it provides a similar survival time (OS or RFS) and superior renal function. Nevertheless, this result is still disputed, and more high-quality studies are required.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.